Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-22T18:48:04.227Z Has data issue: false hasContentIssue false

Cognitive training for persons with mild cognitive impairment

Published online by Cambridge University Press:  01 February 2008

Sylvie Belleville*
Affiliation:
Research Center, Institut Universitaire de Gériatrie de Montréal, Canada
Get access

Abstract

Recent randomized control trials and meta-analyses of experimental studies indicate positive effects of non-pharmacological cognitive training on the cognitive function of healthy older adults. Furthermore, a large-scale randomized control trial with older adults, independent at entry, indicated that training delayed their cognitive and functional decline over a five-year follow-up. This supports cognitive training as a potentially efficient method to postpone cognitive decline in persons with mild cognitive impairment (MCI). Most of the research on the effect of cognitive training in MCI has reported increased performance following training on objective measures of memory whereas a minority reported no effect of training on objective cognitive measures. Interestingly, some of the studies that reported a positive effect of cognitive training in persons with MCI have observed large to moderate effect size. However, all of these studies have limited power and few have used long-term follow-ups or functional impact measures. Overall, this review highlights a need for a well-controlled randomized trial to assess the efficacy of cognitive training in MCI. It also raises a number of unresolved issues including proper outcome measures, issues of generalization and choice of intervention format.

Type
MCI CONFERENCE PAPER
Copyright
Copyright © International Psychogeriatric Association 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adam, S., Van Der Linden, M., Juillerat, A. C., and Salmon, E. 2000. The cognitive management of daily activities in patients with mild to moderate Alzheimer's disease in a day-care centre: a case report. Neuropsychological Rehabilitation, 10, 485509.CrossRefGoogle Scholar
Ball, K. et al. 2002. Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA, 288, 22712281.CrossRefGoogle ScholarPubMed
Baron, A. and Mattila, W. R. 1989. Response slowing of older adults: effects of time-limit contingencies on single- and dual-task performances. Psychology and Aging, 4, 6672.CrossRefGoogle ScholarPubMed
Belleville, S., Lepage, É., Bherer, L., Chetrkow, H. and Gauthier, S. 2002. Measures of executive functions and working memory in older persons with mild cognitive impairment. Paper presented at the ninth Cognitive Aging Conference, Atlanta, GA, U.S.A.Google Scholar
Belleville, S., Gilbert, B., Fontaine, F., Gagnon, L., Menard, E. and Gauthier, S. 2006. Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program. Dementia and Geriatric Cognitive Disorders, 22, 486499.CrossRefGoogle ScholarPubMed
Belleville, S., Chetrkow, H. and Gauthier, S. 2007. Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment. Neuropsychology, 21, 456469.CrossRefGoogle ScholarPubMed
Brooks, J. O. III, Friedman, L., Pearman, A. M., Gray, C. and Yesavage, J. A. 1999. Mnemonic training in older adults: effects of age, length of training, and type of cognitive pretraining. International Psychogeriatrics, 11, 7584.CrossRefGoogle ScholarPubMed
Cipriani, G., Bianchetti, A. and Trabucchi, M. 2006 Outcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment (MCI): a case control study. Archives of Gerontology and Geriatry, 43, 327335.CrossRefGoogle Scholar
Clare, L., Woods, R. T., Moniz Cook, E. D., Orrell, M. and Spector, A. 2005. Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia (Cochrane Review). The Cochrane Library, Issue 2. Wiley.Google Scholar
Flicker, C., Ferris, S. H. and Reisberg, B. 1991 Mild cognitive impairment in the elderly: predictors of dementia. Neurology, 41, 10061009.CrossRefGoogle ScholarPubMed
Geslani, D. M., Tierney, M. C., Herrman, N. and Szalai, J. P. 2005 Mild cognitive impairment: an operational definition and its conversion rate to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 19, 383389.CrossRefGoogle ScholarPubMed
Günther, V. K., Schafer, P., Holzner, B. J. and Kemmler, G. W. 2003. Long-term improvements in cognitive performance through computer-assisted cognitive training: a pilot study in a residential home for older people. Aging and Mental Health, 7, 200206.CrossRefGoogle Scholar
Kramer, A. F., Larish, J. F. and Strayer, D. L. 1995. Training for attentional control in dual task settings: a comparison of young and old adults. Journal of Experimental Psychology: Applied, 1, 5076.Google Scholar
Kramer, A. F., Bherer, L., Colcombe, S. J., Dong, W. and Greenough, W. T. 2004. Environmental influences on cognitive and brain plasticity during aging. Journal of Gerontology: Medical Sciences, 59, 940957.Google ScholarPubMed
Lekeu, F., Wojtasik, V., Van Der Linder, M. and Salmon, E. 2002. Training early Alzheimer patients to use a mobile phone. Acta Neurologica Belgica, 102, 114121.Google ScholarPubMed
Mattis, S. 1976. Mental status examination for organic mental syndrome in the elderly patient. In Bellak, R. and Karasu, T. B. (eds.), Geriatric Psychiatry (pp. 77121). New York: Grune & Stratton.Google Scholar
Nyberg, L. et al. 2003. Neural correlates of training-related memory improvements in adulthood and aging. Proceedings of the National Academy of Sciences of the United States of America, 100, 1372813733.CrossRefGoogle ScholarPubMed
Olazaran, J. et al. 2004. Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology, 63, 23482353.CrossRefGoogle ScholarPubMed
Petersen, R. C. and Morris, J. C. 2005 Mild cognitive impairment as a clinical entity and treatment target. Archives of Neurology, 62, 11601163.CrossRefGoogle ScholarPubMed
Rapp, S., Brenes, G. and Marsh, A. P. 2002. Memory enhancement training for older adults with mild cogntive impairment: a preliminary study. Aging and Mental Health, 6, 511.CrossRefGoogle Scholar
Requena, C., Lopez Ibor, M. I., Maestu, F., Campo, P., Lopez Ibor, J. J. and Ortiz, T. 2004. Effects of cholinergic drugs and cognitive training on dementia. Dementia and Geriatric Cognitive Disorders, 18, 5054.CrossRefGoogle ScholarPubMed
Rozzini, L., Costardi, D., Vicini Chilovi, B., Franzoni, S., Trabucchi, M. and Padovani, A. 2007 Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International Journal of Geriatric Psychiatry, 22, 356360.CrossRefGoogle ScholarPubMed
Stigsdotter, A. and Bäckman, L. 1995. Effects of multifactorial memory training in old age: generalizability across tasks and individuals. Journals of Gerontology, Series B: Psychological Sciences, 50, 134140.Google Scholar
Talassi, E., Guerrreschi, M., Feriani, M., Fedi, V., Bianchetti, A. and Trabucchi, M. 2007 Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study. Archives of Gerontology and Geriatrics, 1 (Suppl.), 391399.CrossRefGoogle Scholar
Valenzuela, M. J. et al. 2003. Memory training alters hippocampal neurochemistry in healthy elderly. Aging, 14, 13331337.Google ScholarPubMed
Van der Linden, M., Juillerat, A-C. and Delbeuck, X. 2004. Cognitive rehabilitation in mild cognitive impairment and prodromal Alzheimer's disease. In Gauthier, S., Scheltens, P. and Cummings, J. (eds.), Alzheimer's Disease and Related Disorders Annual (pp. 8196). London: Martin Dunitz.Google Scholar
Verhaeghen, P., Marcoen, A. and Goossens, L. 1992. Improving memory performance in the aged through mnemonic training: a meta-analytic study. Psychology and Aging, 7, 242251.CrossRefGoogle ScholarPubMed
West, R. L. and Yassuda, M. S. 2004. Aging and memory control beliefs: performance in relation to goal setting and memory self-evaluation. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 59, 5665.CrossRefGoogle ScholarPubMed
Willis, S. L. et al. 2006. Long term effects of cognitive training on everyday functional outcomes in older adults. JAMA, 296, 2805–1814.CrossRefGoogle ScholarPubMed
Yesavage, J. A., Sheikh, J. I., Friedman, L. and Tanke, E. 1990. Learning mnemonics: roles of aging and subtle cognitive impairment. Psychology and Aging, 5, 133137.CrossRefGoogle ScholarPubMed