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Cognitive decline in the behavioral variant of frontotemporal dementia

Published online by Cambridge University Press:  14 September 2010

Janine Diehl-Schmid ,
Susanne Bornschein ,
Corina Pohl ,
Hans Förstl ,
Alexander Kurz  and
Thomas Jahn
Janine Diehl-Schmid*
Affiliation:
Department of Psychiatry of Technische Universität München, Munich, Germany
Susanne Bornschein
Affiliation:
Department of Psychiatry of Technische Universität München, Munich, Germany
Corina Pohl
Affiliation:
Department of Psychiatry of Technische Universität München, Munich, Germany
Hans Förstl
Affiliation:
Department of Psychiatry of Technische Universität München, Munich, Germany
Alexander Kurz
Affiliation:
Department of Psychiatry of Technische Universität München, Munich, Germany
Thomas Jahn
Affiliation:
Department of Psychiatry of Technische Universität München, Munich, Germany
*
Correspondence should be addressed to: Dr. Janine Diehl-Schmid, Center for Cognitive Disorders, Department of Psychiatry of TU München, Ismaninger Str. 22, 81675 München, Germany. Phone: +49–89-41406488; Fax: +49–89-41404923. Email: [email protected].
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Abstract

Background: Only a small number of studies on the natural disease course in behavioral variant frontotemporal dementia (bvFTD) have been conducted. This is surprising because knowledge about the progression of symptoms is a precondition for the design of clinical drug trials.

Methods: The aim of the present study was to examine the cognitive decline of 20 patients with mild bvFTD over one year using the Consortium to Establish a Registry for Alzheimer's Disease – Neuropsychological Assessment Battery (CERAD-NAB).

Results: Within an average follow-up interval of 13 months, patient scores declined significantly in the Mini-mental-State-Examination (MMSE) and the CERAD-NAB subtests of naming, verbal and nonverbal memory. No significant changes were found in the CERAD-NAB subtests of category fluency, recognition, and visuoconstruction. The average annualized decline on the MMSE was 4.0 ± 4.9 points. Ceiling effects were detected in Figures Copy, Word List Recognition and Modified Boston Naming Test. Though the included patient group was rather homogeneous regarding severity of dementia, the cognitive changes were very heterogeneous.

Conclusion: Given the heterogeneity of cognitive decline, the design of a test battery for clinical trials in FTD will be challenging. A cognitive battery should definitely include the MMSE, Word List Learning and Word List Delayed Recall.

Keywords

frontotemporal dementia (FTD)cognitive declineCERAD-NABMMSEneuropsychologyannual rate of change
Type
Research Article
Information
International Psychogeriatrics , Volume 23 , Issue 2 , March 2011 , pp. 230 - 237
Copyright
Copyright © International Psychogeriatric Association 2010

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References

Blair, M., Marczinski, C., Davis-Faroque, N. and Kertesz, A. (2007). A longitudinal study of language decline in Alzheimer's disease and frontotemporal dementia. Journal of the International Neuropsychological Society, 13, 237–245.CrossRefGoogle ScholarPubMed
Boxer, A. L. et al. (2009). An open-label study of memantine treatment in 3 subtypes of frontotemporal lobar degeneration. Alzheimer Disease and Associated Disorders, 23, 211–217.Google Scholar
Borroni, B. et al. (2010). Is frontotemporal lobar degeneration a rare disorder? Evidence from a preliminary study in Brescia County, Italy. Journal of Alzheimer's Disease, 19, 111–116.CrossRefGoogle ScholarPubMed
Chandler, M. et al. (2005). A total score for the CERAD neuropsychological battery. Neurology, 65, 102–106.CrossRefGoogle ScholarPubMed
Chow, T., Hynan, L. and Lipton, A. (2006). MMSE scores decline at a greater rate in frontotemporal degeneration than in AD. Dementia and Geriatric Cognitive Disorders, 22, 194–199.CrossRefGoogle Scholar
Cummings, J. (1996). The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology, 48 (Suppl 6), S10–S16.Google Scholar
Diehl, J. and Kurz, A. (2002). Frontotemporal dementia: patient characteristics, cognition, and behaviour. International Journal of Geriatric Psychiatry, 17, 914–918.CrossRefGoogle ScholarPubMed
Diehl, J. et al. (2005). Frontotemporal dementia, semantic dementia and Alzheimer's disease: the contribution of standard neuropsychological tests to differential diagnosis. Journal of Geriatric Psychiatry and Neurology, 18, 39–44.CrossRefGoogle ScholarPubMed
Diehl, J. et al. (2007). Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study. Neurobiology of Aging, 28, 42–50.Google Scholar
Diehl-Schmid, J., Pohl, C., Perneczky, R., Förstl, H. and Kurz, A. (2006). Behavioral disturbances in the course of frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 22, 352–357.CrossRefGoogle ScholarPubMed
Diehl-Schmid, J., Förstl, H., Perneczky, R., Pohl, C. and Kurz, A. (2008). A 6-month, open-label study of memantine in patients with frontotemporal dementia. International Journal of Geriatric Psychiatry, 49, 390–398.Google Scholar
Ferrer, I. (1999). Neurons and their dendrites in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 10 (Suppl. 1), S55–S60.CrossRefGoogle ScholarPubMed
Grossman, M. et al. (2007). Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia. Archives of Neurology, 64, 1601–1609.CrossRefGoogle ScholarPubMed
Grossman, M. et al. (2008). Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology, 70, 2036–2045.CrossRefGoogle ScholarPubMed
Han, L., Cole, M., Bellavance, F., McCusker, J. and Primeau, F. (2000). Tracking cognitive decline in Alzheimer's disease using the Mini-mental State Examination: a meta-analysis. International Psychogeriatrics, 12, 231–247.CrossRefGoogle ScholarPubMed
Hodges, H. and Miller, B. (2001). The neuropsychology of frontal variant frontotemporal dementia and semantic dementia. Introduction to the special topic papers, Part II. Neurocase, 7, 113–121.CrossRefGoogle Scholar
Hodges, J. et al. (2004). Clinicopathological correlates in frontotemporal dementia. Annals of Neurology, 56, 399–406.CrossRefGoogle ScholarPubMed
Hodges, J. and Patterson, K. (2007). The neuropsychology of frontotemporal dementia. In Hodges, J. (ed.), Frontotemporal Dementia Syndromes (pp. 102–134). Cambridge: Cambnridge University Press.CrossRefGoogle Scholar
Huey, E. D., Putnam, K. T. and Grafman, J. (2006). A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology, 66, 17–22.CrossRefGoogle ScholarPubMed
Kertesz, A., Davidson, W. and Fox, H. (1997). Frontal Behavioral Inventory: diagnostic criteria for frontal lobe dementia. Canadian Journal of Neurological Science, 24, 29–36.CrossRefGoogle ScholarPubMed
Knopman, D. S. et al. (2007). Longitudinal tracking of FTLD. Toward developing clinical trial methodology. Alzheimer Disease and Associated Disorders, 21, S58–S63.Google Scholar
Knopman, D. et al. (2008). Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain, 131, 2957–2968.Google Scholar
Kramer, J. et al. (2003). Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cognitive and Behavioral Neurology, 16, 211–218.CrossRefGoogle ScholarPubMed
Libon, D. et al. (2009). Neuropsychological decline in frontotemporal lobar degeneration: a longitudinal analysis. Neuropsychology, 23, 337–346.CrossRefGoogle ScholarPubMed
Marczinski, C., Davidson, W. and Kertesz, A. (2004). A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia. Cognitive and Behavioral Neurology, 17, 185–190.Google Scholar
Neary, D. et al. (1998). Frontotemporal lobar degeneration:a consensus on clinical diagnostic criteria. Neurology, 51, 1546–1554.Google Scholar
Osher, J., Wicklund, A., Rademaker, A., Johnson, N. and Weintraub, S. (2008). The Mini-mental State Examination in behavioral variant frontotemporal dementia and primary progressive aphasia. American Journal of Alzheimer's Disease and Other Dementias, 22, 468–473.CrossRefGoogle Scholar
Pasquier, F., Richard, F. and Lebert, F. (2004). Natural history of frontotemporal dementia: comparison with Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 17, 253–257.CrossRefGoogle ScholarPubMed
Rascovsky, K. et al. (2005). Rate of progression differs in frontotemporal dementia and Alzheimer disease. Neurology, 65, 397–403.CrossRefGoogle ScholarPubMed
Rascovsky, K., Salmon, D., Hansen, L. and Galasko, D. (2008). Distinct cognitive profiles and rates of decline on the Mattis Dementia Rating Scale in autopsy-confirmed frontotemporal dementia and Alzheimer's'disease. Journal of the International Neuropsychological Society, 14, 373–383.CrossRefGoogle ScholarPubMed
Rogers, T., Ivanoiu, A., Patterson, K. and Hodges, J. (2006). Semantic memory in Alzheimer's disease and the frontotemporal dementias: a longitudinal study of 236 patients. Neuropsychology, 20, 319–335.CrossRefGoogle ScholarPubMed
Rohrer, J. et al. (2008). Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene Archives of Neurology, 65, 506–513.CrossRefGoogle ScholarPubMed
Sheikh, J. and Yesavage, J. (1986). Geriatric Depression Scale; recent findings and development of a short version. In Brink, T. (ed.), Clinical Gerontology: A Guide to Assessment and Intervention. New York: Howarth.Google Scholar
Stern, R. G. et al. (1994). A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration. American Journal of Psychiatry, 115, 390–396.Google Scholar
Welsh, K. A. et al. (1994). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology, 44, 609–614.Google Scholar
Whitwell, J., Anderson, V., Scahill, R., Rossor, M. and Fox, N. (2004). Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degeneration. Dementia and Geriatric Cognitive Disorders, 17, 307–310.CrossRefGoogle ScholarPubMed
Wicklund, A., Rademaker, A., Johnson, N., Weitner, B. and Weintraub, S. (2007). Rate of cognitive change measured by neuropsychological test performance in 3 distinct dementia syndromes. Alzheimers Disease and Associated Disorders, 21, S70–S78.CrossRefGoogle ScholarPubMed