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Cardiovascular health and cognitive functioning among centenarians: a comparison between the Tokyo and Georgia centenarian studies

Published online by Cambridge University Press:  21 February 2019

Peter Martin ,
Yasuyuki Gondo ,
Yasumichi Arai ,
Yoshiko Ishioka ,
Mary Ann Johnson ,
L. Stephen Miller ,
John L. Woodard ,
Leonard W. Poon  and
Nobuyoshi Hirose
Peter Martin*
Affiliation:
Iowa State University, Ames, IA, USA
Yasuyuki Gondo
Affiliation:
Osaka University, Suita, Japan
Yasumichi Arai
Affiliation:
Keio University, Tokyo, Japan
Yoshiko Ishioka
Affiliation:
Keio University, Tokyo, Japan
Mary Ann Johnson
Affiliation:
University of Nebraska - Lincoln
L. Stephen Miller
Affiliation:
University of Georgia, Athens, GA, USA
John L. Woodard
Affiliation:
Wayne State University
Leonard W. Poon
Affiliation:
University of Georgia, Athens, GA, USA
Nobuyoshi Hirose
Affiliation:
Keio University, Tokyo, Japan
*
Correspondence should be addressed to: Peter Martin, Department of Human Development & Family Studies, 1096 LeBaron Hall, Iowa State University, Ames, IA 50011, USA. Phone: 515-294-5186. Fax: 515-294-2502. Email: [email protected].
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Abstract

Objectives:

Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan.

Design, Setting, and Participants:

This cross-national design compared centenarians from the United States and Japan. The sample of U.S. centenarians was recruited from the Georgia Centenarian Study and included 287 centenarians. The sample of Japanese centenarians was recruited from the Tokyo Centenarian Study and included 304 centenarians.

Measurements:

Cognitive functioning was assessed with a mental status questionnaire, and cardiovascular disease by a health history assessment, blood pressure, and selected blood parameters.

Results:

The results suggest that Tokyo centenarians had lower disease experiences and BMI values, when compared to Georgia centenarians, but blood pressure was higher among Japanese centenarians. Lower levels of hemoglobin in Japanese centenarians and higher levels of C-reactive protein in Georgia were also found. The positive association of hypertension and albumin levels with cognitive functioning and the negative association of stroke occurrence with cognitive functioning were replicated in both countries. Differential effects were obtained for heart problems, BMI, and C-reactive protein (with positive effects for Tokyo centenarians, except for C-reactive protein).

Conclusion:

For extremely old individuals, some markers of cardiovascular disease are replicable across countries, whereas differential effects for cardiovascular health also need to be considered in cardiovascular health.

Keywords

centenarianscardiovascular healthcognitive functioning
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 4: Issue Theme: Aging and Well-Being , April 2019 , pp. 455 - 465
Copyright
© International Psychogeriatric Association 2019 

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References

Andersen-Ranberg, K., Schroll, M. and Jeune, B. (2001). Healthy centenarians do not exist, but autonomous do: a population-based study of morbidity among Danish centenarians. Journal of Geriatrics Society, 49, 900–908. doi: 10.1046/j.1532-5415.2001.49180.x.CrossRefGoogle Scholar
Arai, Y. et al. (2001). Lipoprotein metabolism in Japanese centenarians: effects of Apolipoprotein E polymorphism and nutritional status. Journal of the American Geriatrics Society, 49, 1434–1441. doi: 10.1046/j.1532-5415.2001.4911234.x.CrossRefGoogle ScholarPubMed
Arai, Y., Sasaki, T. and Hirose, N. (2017). Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Honshu, Japan: part 2 Honshu, Japan. Mechanisms of Ageing and Development, 165, 80–85. doi: 10.1016/j.mad.2017.02.005.CrossRefGoogle ScholarPubMed
Arnold, J. et al. (2010). Predicting successful aging in a population-based sample of Georgia centenarians. Current Gerontology and Geriatrics Research, 2010, 1–9. doi: 10.1155/2010/989315.CrossRefGoogle Scholar
Chan, Y.-C., Suzuki, M. and Yamamoto, S. (1999). A comparison of anthropometry, biochemical variables and plasma amino acids among centenarians, elderly and young subjects. Journal of the American College of Nutrition, 18, 358–365. doi: 10.1080/07315724.1999.10718876.CrossRefGoogle ScholarPubMed
Cho, J., Martin, P., Margrett, J., MacDonald, M., Poon, L. W. and Johnson, M. A. (2012). Cohort comparisons in resources and functioning among centenarians: Findings from the Georgia Centenarian Study. International Journal of Behavioral Development, 36, 271–278. doi: 10.1177/0165025412439967.CrossRefGoogle Scholar
Deeg, D. J. H., van Vliet, M. J. G., Kardaun, J. W. P. F. and Huisman, M. (2013). Understanding the mortality decline of older age: Improved life course or improved present period? In: Robine, J.-M., Jagger, C. and Crimmins, E. M. (eds.), Annual Review of Gerontology and Geriatrics: Healthy Longevity: A Global Approach (Vol. 33, pp. 261–291). New York: Springer.Google Scholar
Engberg, H. C., Andersen-Ranberg, K. and Jeune, B. (2008). Cohort changes in cognitive function among Danish Centenarians. Dementia and Geriatric Cognitive Disorders, 26, 153–160. doi: 10.1159/000149819.CrossRefGoogle ScholarPubMed
Evert, J., Lawler, E., Bogan, H. and Perls, T. T. (2003). Morbidity profiles of centenarians: survivors, delayers, and escapers. Journal of Gerontology, Series A: Biological Sciences and Medical Sciences, 58, M232–M237. doi: 10.1093/gerona/58.3.M232.CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198. doi: 10.1016/0022-3956(75)90026-6.CrossRefGoogle ScholarPubMed
Forette, B. (1999). Are common risk factors relevant in the eldest old? In: Robine, J.-M., Forette, B., Franceschi, C. and Allard, M. (eds.), The Paradoxes of Longevity (pp. 73–79). Berlin: Springer.CrossRefGoogle Scholar
Gareri, P. et al. (1996). Hypertension in a group of centenarians. Archives of Gerontology and Geriatrics, 22, 373–376. doi: 10.1016/0167-4943(96)86964-0.CrossRefGoogle Scholar
Gondo, Y. et al. (2006). Functional status of centenarians in Tokyo, Japan: Developing better phenotypes of exceptional longevity. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61, 305–310. doi: 10.1093/gerona/61.3.305.CrossRefGoogle ScholarPubMed
Gondo, Y. and Poon, L. W. (2007). Cognitive function of centenarians and its influence on longevity. Annual Review of Gerontology and Geriatrics, 27, 129–150.Google Scholar
Haslam, A. et al. (2012). Prevalence and predictors of anemia in a population-based study of octogenarians and centenarians in Georgia. Journal of Gerontology: Medical Sciences, 67A, 100–106. doi: 10.1093/gerona/glr151.Google Scholar
Hausman, D. B., Johnson, M. A., Davey, A. and Poon, L. W. (2012a). Body mass index is associated with dietary patterns and health conditions in Georgia centenarians. Journal of Aging Research, 2011, 1–10. doi: 10.4061/2011/138015.CrossRefGoogle Scholar
Hausman, D. B., Fisher, J. G. and Johnson, M. A. (2012b). Protein, lipid, and hematological biomarkers in centenarians: definitions, interpretation and relationships with health. Maturitas, 71, 205–212. doi: 10.1016/j.maturitas.2011.12.002.CrossRefGoogle ScholarPubMed
He, W., Goodkind, D. and Kowal, P. (2016). U.S. Census Bureau, International Population Reports, P95/16-1. An Aging World: 2015. Washington, DC: U.S. Government Publishing Office.Google Scholar
Hirose, N. et al. (1997). Tokyo Centenarian study. 5. Nutritional status of Japanese centenarians. Nihon Ronen Igakkai Zasshi, 34, 324–330. doi: 10.3143/geriatrics.34.324.CrossRefGoogle ScholarPubMed
Hirose, N. et al. (2004). Tokyo Centenarian study: aging inflammation hypothesis. Geriatrics and Gerontology International 4, S182–S185. doi: 10.1111/j.1447-0594.2004.00194.x.CrossRefGoogle Scholar
Huang, J. et al. (2012). Haemoglobin A1c and cognitive function in very old, cognitively intact men. Age and Ageing, 41, 125–128. doi: 10.1093/ageing/afr124.CrossRefGoogle ScholarPubMed
Iso, H. (2011). A Japanese health success story: trends in cardiovascular diseases, their risk factors, and the contribution of public health and personalized approaches. European Association for Predictive, Preventive and Personalised Medicine, 2, 49–57. doi: 10.1007/s13167-011-0067-0.Google ScholarPubMed
Kinsella, K. and Velkoff, V. A. (2001). U.S. Census Bureau, Series P95/01-1. An Aging World: 2001. Washington, DC: U.S. Government Printing Office.Google Scholar
Lamon-Fava, S., Wilson, P. W. F. and Schaefer, E. J. (1996). Impact of body mass index on coronary heart disease risk factors in men and women. Arteriosclerosis, Thrombosis, and Vascular Biology, 16, 1509–1515. doi: 10.1161/01.ATV.16.12.1509.CrossRefGoogle ScholarPubMed
Llewellyn, D. J., Langa, K. M., Friedland, R. P. and Lang, I. A. (2010). Serum albumin concentration and cognitive impairment. Current Alzheimer’s Research, 7, 91–96. doi: 10.2174/156720510790274392.CrossRefGoogle ScholarPubMed
Mori, E., Mitani, Y. and Yamadori, A. (1985). Usefulness of a Japanese version of the Mini-Mental State Test in neurological patients. Shinkei Shinrigaku, 1, 2–10.Google Scholar
Nakagawa, T. and Gondo, Y. (2013). Health care system and policy implications for older adults in Japan. In: Scharlach, A. E. and Hoshino, K. (eds.), Healthy Aging in Sociocultural Context (pp. 53–61). New York: Routledge.Google Scholar
Nilsson, S. E., Read, S., Berg, S., Johansson, B., Melander, A. and Lindblad, U. (2007). Low systolic blood pressure is associated with impaired cognitive function in the oldest old: longitudinal observations in a population-based sample 80 years and older. Aging Clinical and Experimental Research, 19, 41–47. doi: 10.1007/BF03325209.CrossRefGoogle Scholar
Poon, L. W. et al. (2007). Methodological considerations in studying centenarians: Lessons learned from the Georgia Centenarian Studies. In Poon, L. W. and Perls, T. T. (eds.), Annual Review of Gerontology and Geriatrics, Vol. 27. Biopsychosocial Approaches to Longevity (pp. 231–264). New York: Springer.Google Scholar
Poon, L. W., Johnson, M. A., Davey, A., Dawson, D. V., Siegler, I. C. and Martin, P. (2000). Psycho-social predictors of survival among centenarians. In: Martin, P., Rott, C., Hagberg, B. and Morgan, K. (eds.), Centenarians: Autonomy versus Dependence in the Oldest Old (pp. 77–89). New York: Springer Publishing Company.Google Scholar
Rasmussen, S. H. and Andersen-Ranberg, K. (2016). Health in centenarians. In: Pacana, N. A. (ed.), Encyclopedia of Geropsychology (pp. 1005–1018). Singapore: Springer.Google Scholar
Richmond, R. L., Law, J. and KayLambkin, F. (2012). Morbidity profiles and lifetime health of Australian centenarians. Australasian Journal on Ageing, 31, 227–232. doi: 10.1111/j.1741-6612.2011.00570.x.CrossRefGoogle ScholarPubMed
Robine, J.-M., Forette, B., Franceschi, C. and Allard, M. (1999). The Paradoxes of Longevity. Berlin: Springer.CrossRefGoogle Scholar
Sabayan, B., van Vliet, P., de Ruijter, W., Gussekloo, J., de Craen, A. J. and Westendorp, R. G. (2013). High blood pressure, physical and cognitive function, and risk of stroke in the oldest old. Stroke, 44, 15–20. doi: 10.1161/STROKEAHA.112.663062.CrossRefGoogle ScholarPubMed
Selim, A. J. et al. (2005). Comprehensive health status assessment of centenarians: Results from the 1999 large health survey of veteran enrollees. Journal of Gerontology, Series A: Biological Sciences and Medical Sciences, 60, 515–519. doi: 10.1093/gerona/60.4.515.CrossRefGoogle ScholarPubMed
Shah, R. C., Wilson, R. S., Tang, Y., Dong, X., Murray, A. and Bennett, D. A. (2009). Relation of hemoglobin to level of cognitive function in older persons. Neuroepidemiology 32, 40–46. doi: 10.1159/000170905.CrossRefGoogle ScholarPubMed
Shimizu, K., Hirose, N., Arai, Y., Gondo, Y. and Wakida, Y. (2001). Determinants of further survival in centenarians. Geriatrics & Gerontology International, 1, 14–17. doi: 10.1046/j.1444-1586.2001.00005.x.CrossRefGoogle Scholar
Suzuki, M., Akisaka, M., Ashitomi, I., Higa, K. and Nozaki, H. (1995). Chronological study concerning ADL among Okinawan centenarians. Dementia and Geriatric Cognitive Disorders, 32, 416–423. doi: 10.3143/geriatrics.32.416.Google ScholarPubMed
Szewieczek, J. et al. (2015). Mildly elevated blood pressure is a marker for better health status in Polish centenarians. Age, 37, 4. doi: 10.1007/s11357-014-9738-9.CrossRefGoogle ScholarPubMed
Takayama, M. et al. (2007). Morbidity of Tokyo-area centenarians and its relationship to functional status. Journal of Gerontology: Medical Sciences, 62A, 774–782. doi: 10.1093/gerona/62.7.774.Google Scholar
Tamura, M. K. et al. (2010). Hemoglobin concentration and cognitive impairment in the renal reasons for geographic and racial differences in stroke (REGARDS) study. Journal of Gerontology: Series A, Biological Sciences and Medical Sciences, 65, 1380–1386. doi: 10.1093/gerona/glq126.Google Scholar
Terry, D. F., Wilcox, M., McCormick, M. A., Lawler, E. and Perls, T. T. (2003). Cardiovascular advantages among the offspring of centenarians. Journal of Gerontology: Series A: Biological Sciences and Medical Sciences, 58A, M425–M431. doi: 10.1093/gerona/58.5.M425.CrossRefGoogle Scholar
The Italian Multicentric Study on Centenarians (IMSC). (1998). Laboratory parameters of Italian centenarians. Archives of Gerontology and Geriatrics, 27, 67–74. doi: 10.1016/S0167-4943(98)00100-9.CrossRefGoogle Scholar
Vogels, R. L. C., Scheltens, P., Schroeder-Tana, J. M. and Weinstein, H. C. (2007). Cognitive impairment in heart failure: a systematic review of the literature. European Journal of Heart Failure, 9, 440–449. doi: 10.1016/j.ejheart.2006.11.001.CrossRefGoogle ScholarPubMed
Willcox, B. J., Abbott, R. D., Yano, K., Rodriguez, B. L., Willcox, D. C. and Curb, J. D. (2004). C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker. Expert Review in Neurotherapeutics, 4, 507–518. doi: 10.1586/14737175.4.3.507.CrossRefGoogle ScholarPubMed
Willcox, D. C., Willcox, B. J., He, Q., Wang, N. and Suzuki, M. (2008). They really are that old: A validation study of centenarian prevalence in Okinawa. Journal of Gerontology: Series A: Biological Sciences and Medical Sciences, 63, 338–349. doi: 10.1093/gerona/63.4.338.CrossRefGoogle Scholar
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky Kuller, L., Rubin, S. and Harris, T. (2003). Inflammatory markers and cognitive functioning African-American and white elders. Neurology, 61, 76–80. doi: 10.1212/01.WNL.0000073620.42047.D7.CrossRefGoogle ScholarPubMed
Zhou, Y, Flaherty, J. H., Huang, C. Q., Lu, Z. C. and Dong, B. R. (2010). Association between body mass index and cognitive function among Chinese nonagenarians/centenarians. Dementia and Geriatric Cognitive Disorders, 30, 517–524. doi: 10.1159/000322110.CrossRefGoogle ScholarPubMed
Zyczkowska, J., Klich-Raczka, A., Mossakowska, M., Gasowski, J., Wieczorowska-Tobis, K. and Grodzicki, T. (2004). Blood pressure in centenarians in Poland. Journal of Human Hypertension, 18, 713–716. doi: 10.1038/sj.jhh.1001728.CrossRefGoogle ScholarPubMed