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Association between executive dysfunction and hippocampal volume in Alzheimer's disease

Published online by Cambridge University Press:  25 November 2010

Tomoyuki Nagata ,
Shunichiro Shinagawa ,
Yusuke Ochiai ,
Ryo Aoki ,
Hiroo Kasahara ,
Kazutaka Nukariya  and
Kazuhiko Nakayama
Tomoyuki Nagata*
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
Shunichiro Shinagawa
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
Yusuke Ochiai
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Ryo Aoki
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Hiroo Kasahara
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Kazutaka Nukariya
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Kazuhiko Nakayama
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
*
Correspondence should be addressed to: Tomoyuki Nagata, Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, 163-1 Kashiwashita, Kashiwa, Chiba 277-8567, Japan. Phone: +81-4-7164-1111; Fax: +81-4-7164-9374. Email: [email protected].
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Abstract

Background: Some previous research has hypothesized that executive dysfunction in patients with early Alzheimer's disease (AD) occurs as a result of a disconnection between different cerebral areas. The aim of the present study was to evaluate how the hippocampal volume influences executive function as a non-memory cognitive function.

Methods: From 157 consecutive patients with AD or amnestic mild cognitive impairment (A-MCI), we recruited 107 subjects who had a global Clinical Dementia Rating (CDR) of 0.5 or 1.0 and whose degree of hippocampal atrophy had been measured using magnetic resonance imaging (MRI); the severity of atrophy was assessed using the voxel-based specific regional analysis for Alzheimer's disease (VSRAD) system. We divided the subjects into three groups: mild atrophy, 0 < Z-score < 1.0 (N = 21); moderate atrophy, 1.0 ≤ Z-score < 2.0 (N = 46); or severe atrophy, 2.0 ≤ Z-score < 4.0 (N = 40) according to the Z-score and compared the Frontal Assessment Battery (FAB) and its subtest scores between each atrophy group.

Results: The results demonstrated that age, sex ratio, duration of illness, education years, MMSE score, Behave-AD score, and proportion of atrophy area in total brain (%) were not significantly different among the three groups. Only the go/no-go score among the six subtests was significantly lower for increasing atrophy severity (P < 0.05). Furthermore, hippocampal atrophy significantly influenced the go/no-go score independently of interactions from whether the diagnosis was early AD or A-MCI (P < 0.05).

Conclusion: These results support a significant association between hippocampal atrophy and executive dysfunction as a non-memory cognitive impairment in patients with early AD and A-MCI.

Keywords

amnestic mild cognitive impairments (A-MCI)non-memorydisconnection syndromeFrontal Assessment Battery (FAB)voxel-based specific regional analysis for Alzheimer's disease (VSRAD)Statistical Parametric Mapping (SPM)parahippocampal gyrusentorhinal cortex
Type
Research Article
Information
International Psychogeriatrics , Volume 23 , Issue 5 , June 2011 , pp. 764 - 771
Copyright
Copyright © International Psychogeriatric Association 2010

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References

Amieva, H., Phillips, L. H., Della-Sala, S. and Henry, J. D. (2004). Inhibitory functioning in Alzheimer's disease. Brain, 127, 949–964CrossRefGoogle ScholarPubMed
Anan, F. et al. (2010). Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus. Neuroimage, 49, 57–62.CrossRefGoogle ScholarPubMed
Ashburner, J. and Friston, K. J. (2000). Voxel-based morphometry: the methods. Neuroimage, 11, 805–821.Google Scholar
Bai, F. et al. (2009). Abnormal functional connectivity of hippocampus during episodic memory retrieval processing network in amnestic mild cognitive impairment. Biological Psychiatry, 65, 951–958.CrossRefGoogle ScholarPubMed
Baudic, S., Barba, G. D., Thibaudet, M. C., Smagghe, A., Remy, P. and Traykov, L. (2006). Executive function deficit in early Alzheimer's disease and their relations with episodic memory. Archives of Clinical Neuropsychology, 21, 15–21.Google Scholar
Chikazoe, J. et al. (2009). Functional dissociation in right inferior frontal cortex during performance of go/no-go task. Cerebral Cortex, 19, 146–152CrossRefGoogle ScholarPubMed
Collette, F., van der Linden, M., Delrue, G. and Salmon, E. (2002). Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease. Alzheimer Disease and Associated Disorders, 16, 228–238.Google Scholar
Collette, F., Schmidt, C., Scherrer, C., Adam, S. and Salmon, E. (2009). Specificity of inhibitory deficits in normal aging and Alzheimer's disease. Neurobiology of Aging, 30, 875–889Google Scholar
Delbeuck, X., Van Der Linden, M. and Collette, F. (2003). Alzheimer's disease as a disconnection syndrome? Neuropsychology Review, 13, 79–92.CrossRefGoogle ScholarPubMed
Dubois, B., Slachevsky, A., Litvan, I. and Pillon, B. (2000). The FAB: a Frontal Assessment Battery at bedside. Neurology 55, 1621–1626.CrossRefGoogle ScholarPubMed
Drewe, E. A. (1975). Go-no go learning after frontal lobe lesions in humans. Cortex, 11, 8–16.CrossRefGoogle ScholarPubMed
Erkinjuntti, T. (2003). Diagnosis and management of vascular cognitive impairment and dementia. Journal of Neural Transmission, Suppl. 63, 91–109.Google Scholar
Ferreira, L. K., Diniz, B. S., Forlenza, O. V., Busatto, G. F. and Zanetti, M. V. (2009). Neurostructural predictors of Alzheimer's disease: a meta-analysis of VBM studies. Neurobiology of Aging. Epublished ahead of print; doi: 10.1016/j.neurobiolaging.2009.11.008.Google ScholarPubMed
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle ScholarPubMed
Gómez-Isla, T., Price, J. L., McKeel, D. W. Jr., Morris, J. C., Growdon, J. H. and Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. Journal of Neuroscience, 15, 4491–4500.CrossRefGoogle Scholar
Hanyu, H., Sato, T., Takasaki, A., Akai, T. and Iwamoto, T. (2009). Frontal lobe dysfunctions in subjects with mild cognitive impairment. Journal of Neuroscience, 256, 1570–1571Google ScholarPubMed
Hirata, Y. et al. (2005). Voxel-based morphometry to discriminate early Alzheimer's disease from controls. Neuroscience Letters, 382, 269–274.CrossRefGoogle ScholarPubMed
Hughes, C. P., Berg, L., Danziger, W. L., Coben, L. A. and Martin, R. L. (1982). A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566–572.CrossRefGoogle ScholarPubMed
Kessler, J., Mielke, R., Grond, M., Herholz, K. and Heiss, W. D. (2000). Frontal lobe tasks do not reflect frontal lobe function in patients with probable Alzheimer's disease. International Journal of Neuroscience, 104, 1–15.Google Scholar
Langley, L. K., Overmier, J. B., Knopman, D. S. and Prod'Homme, M. M. (1998). Inhibition and habituation: preserved mechanisms of attentional selection in aging and Alzheimer's disease. Neuropsychology, 12, 353–366.Google Scholar
Leuchter, A. F., Newton, T. F., Cook, I. A., Walter, D. O., Rosenberg-Thompson, S. and Lachenbruch, P. A. (1992). Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia. Brain, 115, 1543–1561.Google Scholar
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: report of NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
Mega, M. S. et al. (1997). Mapping histology to metabolism: coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease. Neuroimage, 5, 147–153.CrossRefGoogle ScholarPubMed
Nagata, T. et al. (2010). Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease. International Psychogeriatrics, 22, 463–469.CrossRefGoogle ScholarPubMed
Petersen, R. C. et al. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58, 1985–1992.CrossRefGoogle ScholarPubMed
Raji, C. A., Lopez, O. L., Kuller, L. H., Carmichael, O. T. and Becker, J. T. (2009). Age, Alzheimer disease, and brain structure. Neurology, 73, 1899–1905.Google Scholar
Reisberg, B., Borenstein, J., Salob, S. P., Ferris, S. H., Franssen, E. H. and Georgotas, A. (1987). Behavioral symptoms in Alzheimer's disease: phenomenology and treatment. Journal of Clinical Psychiatry, 48 (5 Suppl.), 9–15.Google Scholar
Schroeter, M. L., Stein, T., Maslowski, N. and Neumann, J. (2009). Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients. Neuroimage, 47, 1196–1206.CrossRefGoogle ScholarPubMed
Takahashi, H. et al. (2007). Memory and frontal lobe functions: possible relations with dopamine D2 receptors in the hippocampus. Neuroimage, 34, 1643–1649.CrossRefGoogle ScholarPubMed
Takagi, R., Kajimoto, Y., Kamiyoshi, S., Miwa, H. and Kondo, T. (2002). The frontal assessment battery at bedside (FAB) in patients with Parkinson's disease. No Shinkei, 54, 897–902 (in Japanese).Google ScholarPubMed
Traykov, L. et al. (2007). Executive functions deficit in mild cognitive impairment. Cognitive and Behavioral Neurology, 20, 219–224.Google Scholar
Tulving, E. and Markowitsch, H. J. (1998). Episodic and declarative memory: role of the hippocampus. Hippocampus, 8, 198–204.Google Scholar