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Assessing mild behavioral impairment with the mild behavioral impairment checklist in people with subjective cognitive decline

Published online by Cambridge University Press:  18 July 2018

Sabela C. Mallo Open the ORCID record for Sabela C. Mallo [Opens in a new window] ,
Zahinoor Ismail Open the ORCID record for Zahinoor Ismail [Opens in a new window] ,
Arturo X. Pereiro ,
David Facal ,
Cristina Lojo-Seoane ,
María Campos-Magdaleno Open the ORCID record for María Campos-Magdaleno [Opens in a new window]  and
Onésimo Juncos-Rabadán
Sabela C. Mallo*
Affiliation:
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain
Zahinoor Ismail
Affiliation:
Department of Psychiatry and the Mathison Centre for Mental Health Research & Education, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Department of Clinical Neurosciences and Hotchkiss Brain Institute, and The Ron and Rene Ward Centre for Healthy Brain Aging Research, University of Calgary, Calgary, Alberta, Canada
Arturo X. Pereiro
Affiliation:
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain
David Facal
Affiliation:
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain
Cristina Lojo-Seoane
Affiliation:
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain
María Campos-Magdaleno
Affiliation:
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain
Onésimo Juncos-Rabadán
Affiliation:
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain
*
Correspondence should be addressed to: Sabela C. Mallo, Developmental Psychology, University of Santiago de Compostela, Xosé María Suárez Núñez Street, Campus Sur, Santiago de Compostela, ES–15782, Spain. Phone +34 881-813-949; Fax +34 881-813-901. Email: [email protected].
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Abstract

Objectives:

To estimate the prevalence of Mild Behavioral Impairment (MBI) in people with Subjective Cognitive Decline (SCD), and validate the Mild Behavioral Impairment Checklist (MBI-C) with respect to score distribution, sensitivity, specificity, and utility for MBI diagnosis, as well as correlation with other neuropsychological tests.

Design:

Correlational study with a convenience sampling. Descriptive, logistic regression, ROC curve, and bivariate correlations analyses were performed.

Setting:

Primary care health centers.

Participants:

127 patients with SCD.

Measurements:

An extensive evaluation, including Questionnaire for Subjective Memory Complaints, Mini-Mental State Examination, Cambridge Cognitive Assessment-Revised, Neuropsychiatric Inventory-Questionnaire (NPI-Q), the Geriatric Depression Scale-15 items (GDS-15), the Lawton and Brody Index and the MBI-C, which was administered by phone to participants’ informants.

Results:

MBI prevalence was 5.8% in those with SCD. The total MBI-C scoring was low and differentiated people with MBI at a cut-off point of 8.5 (optimizing sensitivity and specificity). MBI-C total scoring correlated positively with NPI-Q, Questionnaire for Subjective Cognitive Complaints (QSCC) from the informant and GDS-15.

Conclusions:

The phone administration of the MBI-C is useful for detecting MBI in people with SCD. The prevalence of MBI in SCD was low. The MBI-C detected subtle Neuropsychiatric symptoms (NPS) that were correlated with scores on the NPI-Q, depressive symptomatology (GDS-15), and memory performance perceived by their relatives (QSCC). Next steps are to determine the predictive utility of MBI in SCD, and its relation to incident cognitive decline over time.

Keywords

subjective cognitive declineneuropsychiatric symptomsmild behavioral impairmentvalidationprevalence
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 2: Issue Theme: Positive Psychiatry II , February 2019 , pp. 231 - 239
Copyright
Copyright © International Psychogeriatric Association 2018 

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References

Agüera-Ortiz, L. and López-Álvarez, J. (2017). Deterioro comportamental leve: un nuevo concepto para las fases prodrómicas de la demencia. Revista Española de Geriatría y Gerontología, 52, 24–27.10.1016/S0211-139X(18)30076-3Google Scholar
Albert, M. S. et al. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the national institute on aging-alzheimer's association workgroups on diagnostic guidelines for alzheimer's disease. Alzheimer's & Dementia, 7, 270–279. doi:10.1016/j.jalz.2011.03.008.Google Scholar
Balash, Y. et al. (2013). Subjective memory complaints in elders: depression, anxiety, or cognitive decline?. Acta Neurologica Scandinavica, 127, 344–350. doi:10.1111/ane.12038.Google Scholar
Benedet, M. J. and Seisdedos, N. (1996) Evaluación Clínica De las Quejas de Memoria en La vida Cotidiana. Madrid: Editorial Médica Panamericana.Google Scholar
Boada, M. et al. (2002). Neuropsychiatric inventory questionnaire (NPI-Q): validación española de una forma abreviada del neuropsychiatric inventory (NPI). Neurología, 17, 317–323. doi: 47.440.Google Scholar
Burmester, B., Leathem, J. and Merrick, P. (2016). Subjective cognitive complaints and objective cognitive function in aging: a systematic review and meta-analysis of recent cross-sectional findings. Neuropsychology Review, 26, 376–393. doi: 10.1007/s11065-016-9332-2.Google Scholar
Chin, J. et al. (2014). Are depressive symptomatology and self-focused attention associated with subjective memory impairment in older adults?. International Psychogeriatrics, 4, 573–580. doi:10.1017/S104161021300241XGoogle Scholar
Cieslak, A. et al. (2018) Case series of mild behavioral impairment: toward an understanding of the early stages of neurodegenerative diseases affecting behavior and cognition. International Psychogeriatrics, 30, 273–280. doi:10.1017/S1041610217001855.Google Scholar
Cummings, J. L. et al. (1994). The neuropsychiatric inventory: comprehensive assessment of psychopatlhology in dementia. Neurology, 44, 2308–2314. doi:10.1212/WNL.44.12.2308Google Scholar
Desmarais, P. et al. (2018). Social inappropriateness in neurodegenerative disorders. International Psychogeriatrics, 30, 197–207. doi:10.1017/S1041610217001260.Google Scholar
Fischer, C. E. and Agüera-Ortiz, L. (2018). Psychosis and dementia: risk factor, prodrome, or cause?. International Psychogeriatrics, 30, 209–219. doi:10.1017/S1041610217000874.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198. doi: 10.1016/0022-3956(75)90026-6.Google Scholar
Geda, Y. E. et al. (2014). Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study. American Journal of Psychiatry, 171, 572–581. doi: 10.1176/appi.ajp.2014.13060821.Google Scholar
Gifford, K. A. et al. (2014). The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults. Alzheimer's & Dementia. 10, 319–327. doi:10.1016/j.jalz.2013.02.007.Google Scholar
Ismail, Z. et al. (2016). Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimer's & Dementia, 12, 195–202. doi: 10.1016/j.jalz.2015.05.017.Google Scholar
Ismail, Z. et al. (2018). Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria. International Psychogeriatrics, 30, 185–196. doi:10.1017/S1041610217001880.Google Scholar
Ismail, Z. et al. (2017a). The mild behavioral impairment checklist (MBI-C): a rating scale for neuropsychiatric symptoms in pre-dementia populations. Journal of Alzheimer's Disease, 56, 929–938. doi: 10.3233/JAD-160979.Google Scholar
Ismail, Z. et al. (2017b). Prevalence of depression in patients with mild cognitive impairment: a systematic review and meta-analysis. JAMA Psychiatry, 74, 58–67. doi: 10.1001/jamapsychiatry.2016.3162.Google Scholar
Ismail, Z. and Mortby, M. E. (2017). Cognitive and neuropsychiatric screening tests in older adults. In Chiu, H. et al. (eds.), Mental Health and Illness of the Elderly (pp. 343–368), Singapore: Springer Nature.10.1007/978-981-10-2414-6_16Google Scholar
Jessen, F. et al. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's & Dementia, 10, 844–852. doi:10.1016/j.jalz.2014.01.001.Google Scholar
Juncos-Rabadán, O. et al. (2012). Prevalence and correlates of cognitive impairment in adults with subjective memory complaints in primary care centres. Dementia and Geriatric Cognitive Disorders, 33, 226–232. doi:10.1159/000338607.Google Scholar
Kaufer, D. et al. (2000). Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. Journal of Neuropsychiatry, 12, 233–239. doi: 10.1176/appi.neuropsych.12.2.233.Google Scholar
Lawton, M. P. and Brody, E. M. (1969). Assessment of older people : self-maintaining and instrumental activities of daily living. Gerontologist, 3, 179–186.10.1093/geront/9.3_Part_1.179Google Scholar
Lobo, A., Saza, P., Marcos, G., Díaz, J. L., D la, C. C. and , V. T. (1999). Revalidación y normalización del mini-examen cognoscitivo (primera versión en castellano del mini-mental status examination) en la población general geriátrica. Medicina Clínica (Barcelona), 112, 767–774Google Scholar
López-Pousa, S. (2003) Camdex-R: Prueba de Exploración Cambridge Revisada Para la Valoración De los Trastornos Mentales en la vejez. Adaptación Española. Madrid: TEA Ediciones.Google Scholar
Lyketsos, C. G. et al. (2011). Neuropsychiatric symptoms in Alzheimer's disease. Alzheimer's & Dementia, 7, 532–539. doi:10.1016/j.jalz.2011.05.2410.Google Scholar
Mallo, S. C. et al. (2017). Assessing mild behavioral impairment in people with subjective cognitive complaints (Sccs) with the mild behavioral impairment checklist (Mbi-C): a pilot study. Alzheimer's & Dementia, 13, 364–365. doi:10.1016/j.jalz.2017.06.312.Google Scholar
Martínez, J. et al. (2002). Versión española del cuestionario de Yesavage abreviado (GDS) para el despistaje de depresión en mayores de 65 años: adaptación y validación. Medifam, 12, 620–630. doi:10.4321/S1131-57682002001000003.Google Scholar
Masters, M. C. et al. (2015). “Noncognitive” symptoms of early Alzheimer disease: a longitudinal analysis. Neurology, 84, 617–622. doi:10.1212/WNL.0000000000001238.Google Scholar
McKhann, G. M. et al. (2011). The diagnosis of dementia due to alzheimer's disease: recommendations from the national institute on aging-alzheimer's association workgroups on diagnostic guidelines for alzheimer's disease. Alzheimer's & Dementia, 7, 263–269. doi:10.1016/j.jalz.2011.03.005.Google Scholar
Mewton, L. et al. (2014). Demographic, clinical, and lifestyle correlates of subjective memory complaints in the Australian population. American Journal of Geriatric Psychiatry, 22, 1222–1232. doi: 10.1016/j.jagp.2013.04.004.Google Scholar
Mortby, M. E. et al. (2018). Dementia clinical trial implications of mild behavioral impairment. International Psychogeriatrics, 30, 171–175. doi: 10.1017/S1041610218000042.Google Scholar
Mortby, M. E., Ismail, Z. and Anstey, K. J. (2018). Prevalence estimates of mild behavioral impairment in a population-based sample of pre-dementia states and cognitively healthy older adults. International Psychogeriatrics, 30, 221–232. doi:10.1017/S1041610217001909.Google Scholar
Nagata, T. et al. (2014). Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease. Journal of Neural Transmission, 121, 433–441. doi:10.1007/s00702-013-1121-y.Google Scholar
Pocnet, C. et al. (2015). Behavioral and psychological symptoms and cognitive decline in patients with amnestic MCI and mild AD: a two-year follow-up study. International Psychogeriatrics, 27, 1379–1389. doi:10.1017/S104161021400283X.Google Scholar
Roth, M., Huppert, F. A., Mountjoy, C. Q. and Tym, E. (1998). CAMDEX-R boxed Set: The Revised Cambridge Examination for Mental Disorder of the Elderly. Cambridge: Cambridge University Press.Google Scholar
Sheikh, F. et al. (2018). Prevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden. International Psychogeriatrics, 30, 233–244. doi:10.1017/S104161021700151X.Google Scholar
Sherman, C. et al. (2018). Prevalence, neurobiology, and treatments for apathy in prodromal dementia. International Psychogeriatrics, 2, 177–184. doi:10.1017/S1041610217000527.Google Scholar
Taragano, F. E. et al. (2018). Risk of conversion to dementia in a mild behavioral impairment group compared to a psychiatric group and to a mild cognitive impairment group. Journal of Alzheimers Disease, 62, 227–238. doi:10.3233/jad-170632.Google Scholar
Yesavage, J. A. and Sheikh, J. I. (1986). Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clinical Gerontologist, 5, 165–173. doi:10.1300/J018v05n01_09.Google Scholar