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Venous thromboembolism in psychogeriatric in-patients – A study of risk assessment, incidence, and current prophylaxis prescribing

Published online by Cambridge University Press:  21 February 2013

Xinsheng Liu
Affiliation:
Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia
Fintan O'Rourke*
Affiliation:
Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia Faculty of Medicine, University of New South Wales, Sydney, Australia
Huong Van Nguyen
Affiliation:
Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia Faculty of Medicine, University of New South Wales, Sydney, Australia
*
Correspondence should be addressed to: Dr Fintan O'Rourke, Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Eldridge Road, Bankstown, NSW 2200, Australia. Phone: +612 9722 8000; Fax: +612 9722 8275. Email: Fintan.O'[email protected].

Abstract

Background: While venous thromboembolism (VTE) risk assessment and prophylaxis is well established for medical and surgical in-patients, there is a paucity of evidence, and therefore guidelines, in this area for psychogeriatric in-patients. We wished to determine VTE incidence, risk, and use of prophylaxis, in a psychogeriatric in-patient population.

Methods: Retrospective audit of consecutive psychogeriatric patients aged 65 years and over admitted to Bankstown Hospital over a 3-year period, 2007–2009. Using an adapted VTE risk scoring system, patients were assigned as low, medium, or high VTE risk.

Results: A total of 192 patients were included in the study. Mean age was 79.1 ± 7.0 years. Out of the total, 55.2% of patients had diagnosis of dementia, and 33.3% had depression. Overall, 81.8% (157/192) were assessed as low risk, and 18.2% (35/192) as medium risk. Also, 16.7% (32/192) received VTE prophylaxis.

Four new VTE events occurred in medium-risk group, and one in low-risk group (p = 0.004). Overall VTE incidence was 10.5/10,000 patient-days, but 44.2 per 10,000 in medium-risk group. VTE risk score was predictive of VTE events – IRR 6.02 (95% Confidence Intervals (CI) = 1.76–20.7, p = 0.004) for every one-point increment in risk. Depression was associated with significantly higher VTE occurrence (6.3% in those with diagnosis vs. 0.8% without, p = 0.043).

Conclusion: Using a VTE risk scoring system adapted for psychogeriatric in-patients, those assessed to be at medium risk had a significantly increased rate of VTE. On this basis, we would recommend VTE prophylaxis be prescribed for psychogeriatric in-patients assessed to be at medium and high level of risk.

Type
Research Article
Copyright
Copyright © International Psychogeriatric Association 2013

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References

Access Economics (2008). The Burden of Venous Thromboembolism in Australia. Report for the Australia and New Zealand Working Party on the Management and Prevention of Venous Thromboembolism. Barton ACT: Access EconomicsGoogle Scholar
Agnelli, G. (2004). Prevention of venous thromboembolism in surgical patients. Circulation, 110, IV4IV12.CrossRefGoogle ScholarPubMed
Alhenc-Gelas, M., Aiach, M. and de Moerloose, P. (2001). Venous thromboembolic disease: risk factors and laboratory investigation. Seminars in Vascular Medicine, 1, 8187.CrossRefGoogle ScholarPubMed
Australia and New Zealand Working Party on Management and Prevention of VTE (2005). Prevention of Venous Thromboembolism: Best Practice Guidelines for Australia and New Zealand, 3rd edn.Baulkam Hills, New South Wales: Health Education and Management Innovations.Google Scholar
Hägg, S., Jönsson, A. K. and Spigset, O. (2009). Risk of venous thromboembolism due to antipsychotic drug therapy. Expert Opinion on Drug Safety, 8, 537547.CrossRefGoogle ScholarPubMed
Hägg, S., Spigset, O. and Soderstrom, T. G. (2000). Association of venous thromboembolism and clozapine. Lancet, 355, 11551156.CrossRefGoogle ScholarPubMed
Liperoti, R., Pedone, C., Lapane, K. L., Mor, V., Bernabei, R. and Gambassi, G. (2005). Venous thromboembolism among elderly patients treated with atypical and conventional antipsychotic agents. Archives of Internal Medicine, 165, 26772682.CrossRefGoogle ScholarPubMed
Malý, R., Masopust, J. and Hosak, L. (2008). Assessment of risk of venous thromboembolism and its possible prevention in psychiatric patients. Psychiatry and Clinical Neurosciences, 62, 38CrossRefGoogle ScholarPubMed
Oger, E. (2000). Incidence of venous thromboembolism: a community-based study in western France. EPI-GETBO Study Group. Groupe d'Etude de la Thrombose de Bretagne Occidentale. Thrombosis and Haemostasis, 83, 657660.Google Scholar
Parker, C., Coupland, C. and Hippisley-Cox, J. (2010). Antipsychotic drugs and risk of venous thromboembolism: nested case-control study. BMJ, 341, c4245CrossRefGoogle ScholarPubMed
Parkin, L., Skegg, D. C., Herbison, G. P. and Paul, C. (2003). Psychotic drugs and fatal pulmonary embolism. Pharmacoepidemiology and Drug Safety, 12, 647652.CrossRefGoogle Scholar
Radcliffe, J. and Smith, R. (2007). Acute in-patient psychiatry: how patients spend their time on acute psychiatric wards. Psychiatric Bulletin, 31, 167170.CrossRefGoogle Scholar
Ray, J. G., Mamdani, M. M. and Yeo, E. L. (2002). Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism. Thrombosis and Haemostasis, 88, 205209.Google ScholarPubMed
Rosendaal, F. R. (1999). Risk factors for venous thrombotic disease. Thrombosis and Haemostasis, 82, 610619.Google ScholarPubMed
Strudsholm, U., Johannessen, L., Foldager, L. and Munk-Jorgensen, P. (2005). Increased risk for pulmonary embolism in patients with bipolar disorder. Bipolar Disorders, 7, 7781.CrossRefGoogle ScholarPubMed
Thomassen, R., Vandenbroucke, J. P. and Rosendaal, F. R. (2001). Antipsychotic medication and venous thrombosis. British Journal of Psychiatry, 179, 6366.CrossRefGoogle ScholarPubMed
Vandenbroucke, J. P.et al. (1998). Factor V Leiden and fatal pulmonary embolism. Thrombosis and Haemostasis, 79, 511516.Google ScholarPubMed
Waage, I. M. and Gedde-Dahl, A. (2003). Pulmonary embolism possibly associated with olanzapine treatment. BMJ, 37, 1384.CrossRefGoogle Scholar
Zornberg, G. and Jick, H. (2000). Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study. Lancet, 356, 12191223.CrossRefGoogle ScholarPubMed