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Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders

Published online by Cambridge University Press:  08 April 2015

Zheng-Yu Wang ,
Zhen-Min Han ,
Qi-Fei Liu ,
Wei Tang ,
Kui Ye  and
Yu-You Yao
Zheng-Yu Wang
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China
Zhen-Min Han
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China
Qi-Fei Liu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China
Wei Tang
Affiliation:
Department of Clinical Laboratory Medicine, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China
Kui Ye
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China
Yu-You Yao*
Affiliation:
Department of Clinical Laboratory Medicine, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China
*
Correspondence should be addressed to: Yu-You Yao, M.D., Department of Clinical Laboratory Medicine, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China. Phone: 86-551-63869179; Fax: 86-551-63869179. Email: [email protected].
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Abstract

Background:

The etiology and pathogenesis of neurodegenerative disorders has yet to be elucidated, so their differential diagnosis is a challenge. This is especially true in differentiating Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson disease (PD), and multiple system atrophy (MSA).

Methods:

A total of 11 eligible articles were identified by search of electronic databases including PubMed, Springer Link, Elsevier, and the Cochrane Library, up to June 2014. In meta-analyses, standardized mean differences (SMD), with 95% confidence intervals (CI), comparing cerebrospinal fluid (CSF) measures of α-synuclein between the above conditions were calculated using random-effects models.

Results:

CSF α-synuclein concentrations were significantly higher in AD compared to DLB [SMD: 0.32, 95% CI: (0.02, 0.62), z = 2.07, P = 0.038]; PD [SMD: 0.87, 95% CI: (0.15, 1.58), z = 2.38, P = 0.017]; or MSA [SMD: 1.14, 95% CI: (0.15, 2.14), z = 2.25, P = 0.025]. However, no significant difference was found between patients with AD and neurological cognitively normal controls [SMD: 0.02, 95% CI: (−0.21, 0.24), z = 0.13, P = 0.894].

Conclusions:

Results of these meta-analysis suggest that quantification of CSF α-synuclein could help distinguish AD from other neurodegenerative disorders such as DLB, PD, or MSA.

Keywords

Alzheimer’s diseasedementia with Lewy bodiesParkinson diseasemultiple system atrophyα-synucleinmeta-analysis
Type
Review Article
Information
International Psychogeriatrics , Volume 27 , Issue 9 , September 2015 , pp. 1429 - 1438
Copyright
Copyright © International Psychogeriatric Association 2015 

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