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Sleep and mood in older adults: coinciding changes in insomnia and depression symptoms

Published online by Cambridge University Press:  02 August 2017

Michael J. Li Open the ORCID record for Michael J. Li [Opens in a new window] ,
Afton Kechter ,
Richard E. Olmstead ,
Michael R. Irwin  and
David S. Black
Michael J. Li*
Affiliation:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Afton Kechter
Affiliation:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Richard E. Olmstead
Affiliation:
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, California, USA Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Michael R. Irwin
Affiliation:
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, California, USA Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
David S. Black
Affiliation:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
*
Correspondence should be addressed to: Michael J. Li, MPH, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 2001 N Soto Street, 3rd Floor, Los Angeles, CA 90032, USA. Phone: 323 442 8223. Email: [email protected].
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Abstract

The aim of this analysis was to test if changes in insomnia symptoms and global sleep quality are associated with coinciding changes in depressed mood among older adults. We report on results yielded from secondary analysis of longitudinal data from a clinical trial of older adults (N = 49) aged 55 to 80 years who reported at least moderate levels of sleep problems. All measures were collected at baseline and after the trial ten weeks later. We computed change scores for two separate measures of disturbed sleep, the Athens Insomnia Scale (AIS) and the Pittsburgh Sleep Quality Index (PSQI), and tested their association with change in depressed mood (Beck Depression Inventory-II; BDI-II) in two separate linear regression models adjusted for biological covariates related to sleep (sex, age, body mass index, and NF-κB as a biological marker previously correlated with insomnia and depression). Change in AIS scores was associated with change in BDI-II scores (β = 0.38, p < 0.01). Change in PSQI scores was not significantly associated with change in BDI-II scores (β = 0.17, p = 0.26). Our findings suggest that improvements over ten weeks in insomnia symptoms rather than global sleep quality coincide with improvement in depressed mood among older adults.

Keywords

insomniasleepdepressionmoodnuclear factor-kappa Bolder adults
Type
Brief Report
Information
International Psychogeriatrics , Volume 30 , Issue 3: Issue Theme: Psychosocial Interventions for Dementia , March 2018 , pp. 431 - 435
Copyright
Copyright © International Psychogeriatric Association 2017 

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References

Ancoli-Israel, S. and Ayalon, L. (2006). Diagnosis and treatment of sleep disorders in older adults. The American Journal of Geriatric Psychiatry, 14, 95–103.Google Scholar
Beck, A. T., Steer, R. A. and Brown, G. K. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation.Google Scholar
Black, D. S., O'Reilly, G. A., Olmstead, R., Breen, E. C. and Irwin, M. R. (2015). Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Internal Medicine, 175, 494–501.CrossRefGoogle ScholarPubMed
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R. and Kupfer, D. J. (1989). The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Research, 28, 193–213.CrossRefGoogle ScholarPubMed
Irwin, M. R. (2015). Why sleep is important for health: a psychoneuroimmunology perspective. Annual Review of Psychology, 66, 143–172.Google Scholar
Irwin, M. R. and Cole, S. W. (2011). Reciprocal regulation of the neural and innate immune systems. Nature Reviews Immunology, 11, 625–632.Google Scholar
Jaussent, I. et al. (2011). Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly. Sleep, 34, 1103–1110.Google Scholar
Lee, E., Cho, H. J., Olmstead, R., Levin, M. J., Oxman, M. N. and Irwin, M. R. (2013). Persistent sleep disturbance: a risk factor for recurrent depression in community-dwelling older adults. Sleep, 36, 1685–1691.Google Scholar
Maglione, J. E. et al. (2014). Subjective and objective sleep disturbance and longitudinal risk of depression in a cohort of older women. Sleep, 37, 1179–1187.Google Scholar
Manber, R., Bernert, R. A., Suh, S., Nowakowski, S., Siebern, A. T. and Ong, J. C. (2011). CBT for insomnia in patients with high and low depressive symptom severity: adherence and clinical outcomes. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 7, 645–652.Google Scholar
Meeks, T. W., Vahia, I. V., Lavretsky, H., Kulkarni, G. and Jeste, D. V. (2011). A tune in “a minor” can “b major”: a review of epidemiology, illness course, and public health implications of subthreshold depression in older adults. Journal of Affective Disorders, 129, 126–142.CrossRefGoogle Scholar
Perlis, M. L. et al. (2006). Insomnia as a risk factor for onset of depression in the elderly. Behavioral Sleep Medicine, 4, 104.CrossRefGoogle ScholarPubMed
Soldatos, C. R., Dikeos, D. G. and Paparrigopoulos, T. J. (2000). Athens insomnia scale: validation of an instrument based on ICD-10 criteria. Journal of Psychosomatic Research, 48, 555–560.Google Scholar
StataCorp (2015). Stata Statistical Software. College Station, TX: StataCorp LP.Google Scholar