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Mild cognitive impairment (MCI): a historical perspective

Published online by Cambridge University Press:  01 February 2008

Barry Reisberg ,
Steven H. Ferris ,
Alan Kluger ,
Emile Franssen ,
Jerzy Wegiel  and
Mony J. de Leon
Barry Reisberg*
Affiliation:
Aging and Dementia Research Center, New York University School of Medicine, New York, U.S.A.
Steven H. Ferris
Affiliation:
Aging and Dementia Research Center, New York University School of Medicine, New York, U.S.A.
Alan Kluger
Affiliation:
Aging and Dementia Research Center, New York University School of Medicine, New York, U.S.A.
Emile Franssen
Affiliation:
Aging and Dementia Research Center, New York University School of Medicine, New York, U.S.A.
Jerzy Wegiel
Affiliation:
Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, U.S.A.
Mony J. de Leon
Affiliation:
Center for Brain Health, New York University School of Medicine, New York, U.S.A.
*
Correspondence should be addressed to: Barry Reisberg, M.D., Silberstein Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue, New York 10016, U.S.A. Phone: +1 212 263 8550; Fax: +1 212 263 6991. Email: [email protected].
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Abstract

Descriptions of dementia can be traced to antiquity. Prichard (1837) described four dementia stages and Kral (1962) described a “benign senescent forgetfulness” condition. The American Psychiatric Association's DSM-III (1980) identified an early dementia stage.

In 1982, the Clinical Dementia Rating (CDR) and the Global Deterioration Scale (GDS) were published, which identified dementia antecedents. The CDR 0.5 “questionable dementia” stage encompasses both mild dementia and earlier antecedents. GDS stage 3 described a predementia condition termed “mild cognitive decline” or, alternatively, beginning in 1988, “mild cognitive impairment” (MCI). This GDS stage 3 MCI condition is differentiated from both a preceding GDS stage 2, “subjective cognitive impairment” (SCI) stage and a subsequent GDS 4 stage of mild dementia.

GDS stage 3 MCI has been well characterized. For example, specific clinical concomitants, mental status and psychological assessment score ranges, behavioral and emotional changes, neuroimaging concomitants, neurological reflex changes, electrophysiological changes, motor and coordination changes, and changes in activities, accompanying GDS stage 3 MCI have been described.

Petersen and associates proposed a definition of MCI in 2001 which has been widely used (hereafter referred to as “Petersen's MCI”). Important differences between GDS stage 3 MCI and Petersen's MCI are that, because of denial, GDS stage 3 MCI does not require memory complaints. Also, GDS stage 3 MCI recognizes the occurrence of executive level functional deficits, which Petersen's MCI did not. Nevertheless, longitudinal and other studies indicate essential compatibility between GDS stage 3 MCI and Petersen's MCI duration and outcomes.

Keywords

mild cognitive impairmenthistorydementiaAlzheimer's diseasesubjective cognitive impairmentglobal deterioration scale
Type
MCI CONFERENCE PAPER
Information
International Psychogeriatrics , Volume 20 , Issue 1 , February 2008 , pp. 18 - 31
Copyright
Copyright © International Psychogeriatric Association 2007

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References

American Psychiatric Association 1980. Diagnostic and Statistical Manual of Mental Disorders (DSM-III), 3rd edn (pp. 124–126). Washington, D.C.: American Psychiatric Association.Google Scholar
Blessed, G.Tomlinson, B. E. and Roth, M. 1968. The association between quantitative measures of dementia and senile change in the cerebral gray matter of elderly subjects. British Journal of Psychiatry, 114, 797–811.CrossRefGoogle ScholarPubMed
Bobinski, M. et al. 1995. Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease. Dementia, 6, 205–210.Google ScholarPubMed
Bobinski, M. et al. 1997. Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer's disease. Journal of Neuropathology and Experimental Neurology, 56, 414–420.CrossRefGoogle Scholar
Brothwell, D. and Scandison, A. T. 1967. Diseases in Antiquity (p. 718). Springfield, IL: Charles C. Thomas.Google Scholar
Bruscoli, M. and Lovestone, S. 2004. Is MCI really just early dementia? A systematic review of conversion studies. International Psychogeriatrics, 16, 129–140.CrossRefGoogle ScholarPubMed
Clayton, P. J. and Martin, R. 1981. Classification of late life organic states and the DSM-III. In Miller, N. E. and Cohen, G. D. (eds.), Clinical Aspects of Alzheimer's Disease and Senile Dementia (pp.47–59). New York: Raven Press.Google Scholar
de Leon, M. J.George, A. E.Stylopoulos, L. A.Smith, G. and Miller, D. C. 1989. Early marker for Alzheimer's disease: the atrophic hippocampus. Lancet, 2, 672–673.CrossRefGoogle ScholarPubMed
de Leon, M. J. et al. 1993. The radiologic prediction of Alzheimer's disease: the atrophic hippocampal formation. American Journal of Neuroradiology, 14, 897–906.Google ScholarPubMed
Folstein, M. F.Folstein, S. E. and McHugh, P. R. 1975. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle Scholar
Franssen, E. H.Reisberg, B.Kluger, A.Sinaiko, E. and Boja, C. 1991. Cognition independent neurologic symptoms in normal aging and probable Alzheimer's disease. Archives of Neurology, 48, 148–154.CrossRefGoogle ScholarPubMed
Franssen, E. H.Souren, L. E. M.Torossian, C. L. and Reisberg, B. 1999. Equilibrium and limb coordination in mild cognitive impairment and mild Alzheimer's disease. Journal of the American Geriatrics Society, 47, 463–499.CrossRefGoogle ScholarPubMed
Galasko, D. R. et al. 2000. Detailed assessment of cognition and activities of daily living in moderate to severe Alzheimer's disease. Neurobiology of Aging, 21 (Suppl. 1), S168.CrossRefGoogle Scholar
Gilbert, J. G. and Levee, R. F. 1971. Patterns of declining memory. Journal of Gerontology, 26, 70–75.CrossRefGoogle ScholarPubMed
Hughes, C. P.Berg, L.Danzinger, W. L.Coben, L. A. and Martin, R. L. 1982. A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566–572.CrossRefGoogle ScholarPubMed
Kluger, A. et al. 1997. Patterns of motor impairment in normal aging, mild cognitive decline and early Alzheimer's disease. Journal of Gerontology: Psychological Sciences, 52B, P28–P39.CrossRefGoogle ScholarPubMed
Kluger, A.Ferris, S. H.Golomb, J.Mittelman, M. S. and Reisberg, B. 1999. Neuropsychological prediction of decline to dementia in nondemented elderly. Journal of Geriatric Psychiatry and Neurology, 12, 168–179.CrossRefGoogle ScholarPubMed
Kral, A. V. 1962. Senescent forgetfulness: benign and malignant. Canadian Medical Association Journal, 86, 257–260.Google ScholarPubMed
Kral, A. V. 1978. Benign senescent forgetfulness. In Katzman, R., Terry, R. D., and Bick, K. L. (eds.), Alzheimer's Disease: Senile Dementia and Related Disorders (Aging, Vol. 7), (pp. 47–51) New York: Raven Press.Google Scholar
McKhann, G.Drachman, D.Folstein, M.Katzman, R.Price, D. and Stadlan, E. M. 1984. Clinical diagnosis of Alzheimer's disease: report of NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34: 939–944.CrossRefGoogle ScholarPubMed
Meninger, K. 1963. The Vital Balance, New York: The Viking Press.Google Scholar
Petersen, R. C. 2004. Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183–194.CrossRefGoogle ScholarPubMed
Petersen, R. C.Smith, G. E.Waring, S. C.Ivnik, R. J.Tangalos, E. G. and Kokmen, E. 1999. Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56, 303–308.CrossRefGoogle ScholarPubMed
Petersen, R. C.Stevens, J. C.Ganguli, M.Tangalos, E. G.Cummings, J. L. and DeKosky, S. T. 2001. Practice parameter – early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1133–1142.CrossRefGoogle Scholar
Prichard, J. C. 1837. A Treatise on Insanity. Philadelphia: Haswell, Barrington, and Haswell.Google Scholar
Prichep, L. S. et al. 1994. Quantitative EEG correlates of cognitive deterioration in the elderly. Neurobiology of Aging, 15, 85–90.CrossRefGoogle ScholarPubMed
Prichep, L. S. et al. 2006. Prediction of longitudinal cognitive decline in normal elderly using electrophysiological imaging. Neurobiology of Aging, 27, 471–481.CrossRefGoogle ScholarPubMed
Reisberg, B. 1986. Dementia: a systematic approach to identifying reversible causes. Geriatrics, 41 (4), 30–46.Google ScholarPubMed
Reisberg, B. and Ferris, S. H. 1988. The Brief Cognitive Rating Scale (BCRS). Psychopharmacology Bulletin, 24, 629–636.Google ScholarPubMed
Reisberg, B.Ferris, S. H.de Leon, M. J. and Crook, T. 1982. The global deterioration scale for assessment of primary degenerative dementia. American Journal of Psychiatry, 139, 1136–1139.Google ScholarPubMed
Reisberg, B.Schneck, M. K.Ferris, S. H.Schwartz, G. E. and de Leon, M. J. 1983. The brief cognitive rating scale (BCRS): findings in primary degenerative dementia (PDD). Psychopharmacology Bulletin, 19, 47–50.Google Scholar
Reisberg, B.Gordon, B.McCarthy, M.Ferris, S. H. and de Leon, M. J. 1985. Insight and denial accompanying progressive cognitive decline in normal aging and Alzheimer's disease. In: Stanley, B. (ed.), Geriatric Psychiatry: Ethical and Legal Issues (pp. 37–79). Washington, D.C: American Psychiatric Press.Google Scholar
Reisberg, B.Borenstein, J.Salob, S. P.Ferris, S. H.Franssen, E. H and Georgotas, A. 1987. Behavioral symptoms in Alzheimer's disease: phenomenology and treatment. Journal of Clinical Psychiatry, 48 (5 Suppl.), 9–15.Google ScholarPubMed
Reisberg, B. et al. 1988. Stage-specific behavioral, cognitive, and in vivo changes in community residing subjects with age-associated memory impairment and primary degenerative dementia of the Alzheimer type. Drug Development Research, 15, 101–114.CrossRefGoogle Scholar
Reisberg, B.Franssen, E.Sclan, S. G.Kluger, A. and Ferris, S. H. 1989. Stage specific incidence of potentially remediable behavioral symptoms in aging and Alzheimer's disease: a study of 120 patients using the BEHAVE-AD. Bulletin of Clinical Neurosciences, 54, 95–112.Google Scholar
Reisberg, B.Ferris, S. H.Torossian, C.Kluger, A. and Monteiro, I. 1992. Pharmacologic treatment of Alzheimer's disease: a methodologic critique based upon current knowledge of symptomatology and relevance for drug trials. International Psychogeriatrics, 4 (Suppl. 1), 9–42.CrossRefGoogle ScholarPubMed
Reisberg, B.Sclan, S. G.Franssen, E.Kluger, A. and Ferris, S. 1994. Dementia staging in chronic care populations. Alzheimer's Disease and Associated Disorders, 8, S188–S205.Google ScholarPubMed
Reisberg, B. et al. 1996. Mortality and temporal course of probable Alzheimer's disease: a five-year prospective study. International Psychogeriatrics, 8, 291–311.CrossRefGoogle Scholar
Reisberg, B. et al. 1997. Clinical global measures of dementia: position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. Alzheimer Disease and Associated Disorders, 11 (Suppl. 3), 8–18.Google Scholar
Reisberg, B. et al. (2001). The Alzheimer's disease Activities of Daily Living International Scale (ADL-IS). International Psychogeriatrics, 13, 163–181.CrossRefGoogle ScholarPubMed
Rosen, W. G.Mohs, R. C. and Davis, K. L. 1984. A new rating scale for Alzheimer's disease. American Journal of Psychiatry, 141, 1356–1364.Google ScholarPubMed
Wechsler, D. A. 1958. The Measurement and Appraisal of Adult Intelligence. Baltimore: Williams and Wilkins.Google Scholar
Winblad, B. et al. 2004. Mild cognitive impairment–beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240–246.CrossRefGoogle Scholar