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Measuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study

Published online by Cambridge University Press:  30 September 2014

Nathalie Bier ,
Sébastien Grenier ,
Catherine Brodeur ,
Serge Gauthier ,
Brigitte Gilbert ,
Carol Hudon Open the ORCID record for Carol Hudon [Opens in a new window] ,
Émilie Lepage ,
Marie-Christine Ouellet ,
Chantal Viscogliosi  and
Sylvie Belleville
Nathalie Bier
Affiliation:
Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec H3W 1W4, Canada École de Réadaptation, Université de Montréal, Montréal, Québec H3C 3J7, Canada
Sébastien Grenier
Affiliation:
Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec H3W 1W4, Canada Département de Psychologie, Université de Montréal, Montréal, Québec H3C 3J7, Canada
Catherine Brodeur
Affiliation:
McGill Health Center, Montréal, Québec H3G 1A4, Canada Faculty of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada
Serge Gauthier
Affiliation:
Faculty of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada McGill Centre for Studies in Aging, Verdun, Québec H4H 1R2, Canada
Brigitte Gilbert
Affiliation:
Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec H3W 1W4, Canada
Carol Hudon
Affiliation:
Institut Universitaire en santé Mentale de Québec, Québec G1J 2G3, Canada Programme de Psychologie, Université Laval, Québec G1V 0A6, Canada
Émilie Lepage
Affiliation:
Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec H3W 1W4, Canada
Marie-Christine Ouellet
Affiliation:
Programme de Psychologie, Université Laval, Québec G1V 0A6, Canada Centre interdisciplinaire de recherche en réadaptation et intégration sociale, Québec, Québec G1M 2S8, Canada
Chantal Viscogliosi
Affiliation:
Programme de Gérontologie, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada
Sylvie Belleville*
Affiliation:
Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec H3W 1W4, Canada Département de Psychologie, Université de Montréal, Montréal, Québec H3C 3J7, Canada
*
Correspondence should be addressed to: Sylvie Belleville, Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, 4545, Chemin Queen Mary, Montréal, Québec H3W 1W5, Canada. Phone: +514-340-3540 #4767; Fax: +514-340-3530. Email: [email protected].
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Abstract

Background:

Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment (MCI). The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI.

Methods:

One hundred and sixty-two participants with MCI will be recruited. They will be randomized into three groups: cognitive training, psychosocial intervention, and no-contact. Each intervention will last for eight weeks (one session per week) and a booster training session will be provided three months after the end of the intervention. Various proximal and distal outcomes will be measured at pre-intervention as well as at one week, three months, and six months post-training. Proximal outcomes include memory and psychological health measures. Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function. Socio-demographic factors (age, gender, and education), general cognition, personality traits, engagement in activities, and self-efficacy will be used as moderators. Enrolment began in April 2012 and will be completed by December 2014.

Conclusions:

This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions.

Keywords

mild cognitive impairmentcognitive trainingpsychosocial interventionrandomized clinical trialmemorypsychosocial aspectsneuropsychological testing
Type
Protocol-Only Paper
Information
International Psychogeriatrics , Volume 27 , Issue 3 , March 2015 , pp. 511 - 525
Copyright
Copyright © International Psychogeriatric Association 2014 

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