Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-27T00:38:27.105Z Has data issue: false hasContentIssue false
  • English
  • Français

Manic episode precedes development of early dementia: a case report

Published online by Cambridge University Press:  28 May 2010

Li Yu Hu  and
Yuan-Hwa Chou
Li Yu Hu
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
Yuan-Hwa Chou*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
*
Correspondence should be addressed to: Yuan-Hwa Chou MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd, 112, Peitou, Taipei, Taiwan. Phone: +886-2-2871-1290; Fax: +886-2-2876-8403. Email: [email protected].
Get access Rights & Permissions [Opens in a new window]

Abstract

We report a case of a 63-year-old man who experienced his first manic episode, and then, one year later, experienced a second episode which was associated with a significant loss of brain parenchyma. Two computed tomography (CT) brain scans were performed at each manic episode to observe brain structure. Significant loss of brain parenchyma was shown using CT scans. A Mini-mental State Examination (MMSE) score of 29 was observed after the first manic episode and a score of 23 was obtained after the second manic episode. This case report supports the idea that an increased risk of developing dementia exists in patients with major affective disorders.

Keywords

manic episodedementia
Type
Case Report
Information
International Psychogeriatrics , Volume 22 , Issue 5 , August 2010 , pp. 834 - 836
Copyright
Copyright © International Psychogeriatric Association 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abreu, L. N., Issler, C. and Lafer, B. (2009). Valproate-induced reversible pseudoatrophy of the brain and hyperammonemic encephalopathy in a bipolar patient. Australian and New Zealand Journal of Psychiatry, 43, 484–485.Google Scholar
Adler, C. M., Levine, A. D., DelBello, M. P. and Strakowski, S. M. (2005). Changes in gray matter volume in patients with bipolar disorder. Biological Psychiatry, 58, 151–157.CrossRefGoogle ScholarPubMed
Adler, C. M., DelBello, M. P., Jarvis, K., Levine, A., Adams, J. and Strakowski, S. M. (2007). Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biological Psychiatry, 61, 776–781.CrossRefGoogle ScholarPubMed
Appleby, B. S. and Rosenberg, P. (2007). Mania as a possible prodrome to dementia. Journal of Neuropsychiatry and Clinical Neurosciences, 19, 194.CrossRefGoogle ScholarPubMed
Chang, K. et al. (2009). Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study. Journal of Child and Adolescent Psychopharmacology, 19, 51–59.CrossRefGoogle ScholarPubMed
Devanand, D. P. et al. (2007). Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology, 68, 828–836.CrossRefGoogle ScholarPubMed
Kessing, L. V. and Nilsson, F. M. (2003). Increased risk of developing dementia in patients with major affective disorders compared to patients with other medical illnesses. Journal of Affective Disorders, 73, 261–269.CrossRefGoogle ScholarPubMed
McIntosh, A. M. et al. (2007). Progressive grey matter loss in patients with bipolar disorder. European Psychiatry, 22, S256.CrossRefGoogle Scholar
Moorhead, T. W. et al. (2007). Progressive gray matter loss in patients with bipolar disorder. Biological Psychiatry, 62, 894–900.CrossRefGoogle ScholarPubMed
Sirois, F. (2003). Steroid psychosis: a review. General Hospital Psychiatry, 25, 27–33.CrossRefGoogle ScholarPubMed
Thompson, P. M. et al. (2003). Dynamics of gray matter loss in Alzheimer's disease. Journal of Neuroscience, 23, 994–1005.CrossRefGoogle ScholarPubMed
Young, R. C., Murphy, C. F., Heo, M., Schulberg, H. C. and Alexopoulos, G. S. (2006). Cognitive impairment in bipolar disorder in old age: literature review and findings in manic patients. Journal of Affective Disorders, 92, 125–131.CrossRefGoogle ScholarPubMed