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Excessive sleep increased the risk of incidence of cognitive impairment among older Chinese adults: a cohort study based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS)

Published online by Cambridge University Press:  04 March 2021

Ming Zhang ,
Xiaozhen Lv ,
Yulu Chen ,
Lihui Tu ,
Zili Fan ,
Yao Yao ,
Xin Yu ,
Nianhong Guan  and
Huali Wang Open the ORCID record for Huali Wang [Opens in a new window]
Ming Zhang
Affiliation:
Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou510630, China
Xiaozhen Lv
Affiliation:
Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China
Yulu Chen
Affiliation:
Department of Psychology, Teachers’ College, Beijing Union University, No. 5 Waiguan Xie Street, Chaoyang District, Beijing100011, China
Lihui Tu
Affiliation:
Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China
Zili Fan
Affiliation:
Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China
Yao Yao
Affiliation:
Center for Healthy Aging and Development Studies, National School of Development, Peking University, No.5 Yiheyuan Road, Haidian District, Beijing100871, China
Xin Yu
Affiliation:
Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China
Nianhong Guan*
Affiliation:
Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou510630, China
Huali Wang*
Affiliation:
Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health (Sixth Hospital), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University), No. 51 Huayuanbei Road, Haidian District, Beijing100191, China
*
Correspondence should be addressed to: Prof. Huali Wang, Peking University Institute of Mental Health, Beijing100191, China. Phone +86-10-82801983. E-mail: [email protected] or Prof. Nianhong Guan, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. Phone +86-20-85252479. E-mail: [email protected].
Correspondence should be addressed to: Prof. Huali Wang, Peking University Institute of Mental Health, Beijing100191, China. Phone +86-10-82801983. E-mail: [email protected] or Prof. Nianhong Guan, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. Phone +86-20-85252479. E-mail: [email protected].
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Abstract

Study objectives:

Based on a cohort from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we aimed to evaluate the relationship between sleep duration and the incidence of cognitive impairment among older Chinese adults.

Methods:

We conducted a prospective analysis based on 3692 participants from the CLHLS at baseline (in 2011), and as a 3-year follow-up (till 2014), 531 participants (14.4%) had cognitive impairment, which was defined as a Mini-Mental State Examination score <24. Sleep duration was classified into three groups: short (≤5 hours/day), normal (>5 but <10 hours), and long (≥10 hours/day). A logistic regression model was used to examine the association between baseline sleep duration and cognitive impairment after adjusting for sociodemographic data, living habits, and health conditions.

Results:

Five hundred sixty-two participants (15.2%) were in the short-duration group, and 608 participants (16.5%) were in the long-duration group. After adjusting for multiple potential confounders, compared with normal sleep duration, long sleep duration was associated with the incidence of cognitive impairment (OR = 1.309, 95% CI: 1.019–1.683), especially among men (OR = 1.527, 95% CI: 1.041–2.240) and those having a primary and above education level (OR = 1.559, 95% CI: 1.029–2.361). No significant association was observed between short sleep duration and cognitive impairment (OR = 0.860, 95% CI: 0.646–1.145).

Conclusions:

Excessive sleep may increase the risk of cognitive impairment in older individuals. It may be a suggestive sign of early neurodegeneration and may be a useful clinical tool to identify those at a higher risk of progressing to cognitive impairment.

Keywords

cognitive impairmentsleep durationcohortChinese
Type
Original Research Article
Information
International Psychogeriatrics , Volume 34 , Special Issue 8: Issue Theme: Geriatric Mental Health among Chinese Older Adults , August 2022 , pp. 725 - 734
Copyright
© International Psychogeriatric Association 2021

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Footnotes

†

These authors contributed equally to this work.

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