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Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene

Published online by Cambridge University Press:  19 October 2015

Daniel Camilo Aguirre-Acevedo ,
Fabian Jaimes-Barragán ,
Eliana Henao ,
Victoria Tirado ,
Claudia Muñoz ,
Eric M. Reiman ,
Pierre N. Tariot ,
Jessica B. Langbaum  and
Francisco Lopera Open the ORCID record for Francisco Lopera [Opens in a new window]
Daniel Camilo Aguirre-Acevedo*
Affiliation:
Grupo de Neurociencias de Antioquia, Grupo Académico de Epidemiología Clínica, School of Medicine, Medical Research Institute, University of Antioquia, Medellín, Colombia
Fabian Jaimes-Barragán
Affiliation:
Grupo Académico de Epidemiología Clínica and Research Unit, Hospital Pablo Tobón Uribe, School of Medicine, University of Antioquia, Hospital Pablo Tobón Uribe, Medellín, Colombia
Eliana Henao
Affiliation:
Grupo de Neurociencias de Antioquia, School of Medicine, University of Antioquia, Medellín, Colombia
Victoria Tirado
Affiliation:
Grupo de Neurociencias de Antioquia, School of Medicine, University of Antioquia, Medellín, Colombia
Claudia Muñoz
Affiliation:
Grupo de Neurociencias de Antioquia, School of Medicine, University of Antioquia, Medellín, Colombia
Eric M. Reiman
Affiliation:
Banner Alzheimer's Institute, Arizona, USA
Pierre N. Tariot
Affiliation:
Banner Alzheimer's Institute, Arizona, USA
Jessica B. Langbaum
Affiliation:
Banner Alzheimer's Institute, Arizona, USA
Francisco Lopera
Affiliation:
Grupo de Neurociencias de Antioquia, School of Medicine, University of Antioquia, Medellín, Colombia
*
Correspondence should be addressed to: Dr Daniel Camilo Aguirre-Acevedo, Sede de Investigación Universitaria – SIU, Calle 62, No. 52–59, Medellín, Colombia. Phone: +574-219-6090; Fax: +574-219-6444. Email: [email protected]
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Abstract

Background:

This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1).

Methods:

A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years).

Results:

The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity).

Conclusions:

The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD.

Keywords

Alzheimer's diseaseCERADmild cognitive impairmentvaliditysensitivity
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 3 , March 2016 , pp. 503 - 510
Copyright
Copyright © International Psychogeriatric Association 2015 

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