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Concurrent benzodiazepine use in older adults treated with antidepressants in Asia

Published online by Cambridge University Press:  07 December 2017

Xiao-Mei Zhong ,
Fei Wang ,
Qinge Zhang ,
Gabor S. Ungvari ,
Chee H. Ng ,
Helen F. K. Chiu ,
Tian-Mei Si ,
Kang Sim ,
Ajit Avasthi  and
Sandeep Grover Open the ORCID record for Sandeep Grover [Opens in a new window]
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Xiao-Mei Zhong
Affiliation:
Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Hui Hospital), Guangzhou, China Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Fei Wang
Affiliation:
Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Qinge Zhang
Affiliation:
The National Clinical Research Center for Mental Disorders, China &Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China
Gabor S. Ungvari
Affiliation:
The University of Notre Dame Australia/Marian Centre, Perth, Australia Graylands Hospital, Perth, Australia
Chee H. Ng
Affiliation:
Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
Helen F. K. Chiu
Affiliation:
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China
Tian-Mei Si
Affiliation:
Peking University Institute of Mental Health (the sixth hospital) & National Clinical Research Center for Mental Disorders & the Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China
Kang Sim
Affiliation:
Institute of Mental Health, Buangkok View, Buangkok Green Medical Park, Singapore
Ajit Avasthi
Affiliation:
Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Sandeep Grover
Affiliation:
Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Mian-Yoon Chong
Affiliation:
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital-Kaohsiung Medical Center and School of Medicine, Chang Gung University, Taiwan
Kok-Yoon Chee
Affiliation:
Department of Psychiatry & Mental Health, Tunku Abdul Rahman Institute of Neurosciences, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
Shigenobu Kanba
Affiliation:
Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan
Min-Soo Lee
Affiliation:
Department of Psychiatry, College of Medicine, Korea University, Seoul, South Korea
Shu-Yu Yang
Affiliation:
Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan
Pichet Udomratn
Affiliation:
Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
Roy A. Kallivayalil
Affiliation:
Department of Psychiatry, Pushpagiri Institute of Medical Sciences, Thiruvalla, India
Andi J. Tanra
Affiliation:
Department of Psychiatry, Hasanuddin University Faculty of Medicine, Makassar, Sulawesi Selatan, Indonesia
Margarita M. Maramis
Affiliation:
Dr. Soetomo Hospital – Faculty of Medicine, Airlangga University, Jawa Timur, Indonesia
Winston W. Shen
Affiliation:
Departments of Psychiatry, TMU-Wan Fang Medical Center and School of Medicine, Taipei Medical University, Taiwan
Norman Sartorius
Affiliation:
Association for the Improvement of Mental Health Programmes, Geneva, Switzerland
Rathi Mahendran
Affiliation:
Department of Psychological Medicine, National University of Singapore, Singapore
Chay-Hoon Tan
Affiliation:
Department of Pharmacology, National University of Singapore, Singapore
Naotaka Shinfuku
Affiliation:
International Center for Medical Research, Kobe University School of Medicine, Kobe, Japan
Yu-Tao Xiang*
Affiliation:
Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
*
Correspondence should be addressed to: Dr Yu-Tao Xiang, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, 3/F, Building E12, China. Phone: +853-8822-4223; Fax: +853-2288-2314. Email: [email protected].
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Abstract

Background:

Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates.

Methods:

The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Both univariate and multiple logistic regression analyses were performed.

Results:

The proportion of benzodiazepine and antidepressant combination in this cohort was 44.3%. Multiple logistic regression analysis revealed that higher doses of antidepressants, younger age (<65 years), inpatients, public hospital, major comorbid medical conditions, antidepressant types, and country/territory were significantly associated with more frequent co-prescription of benzodiazepines and antidepressants.

Conclusions:

Nearly, half of the older adults treated with antidepressants in Asia are prescribed concurrent benzodiazepines. Given the potentially adverse effects of benzodiazepines, the rationale of benzodiazepines and antidepressants co-prescription needs to be revisited.

Keywords

antidepressantbenzodiazepinesolder adultsAsia
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 5: Issue Theme: Well-Being in Dementia , May 2019 , pp. 685 - 691
Copyright
© International Psychogeriatric Association 2017 

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Footnotes

#

These authors contributed equally to this work.

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