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A clinical survey of pain in Parkinson's disease in Eastern China

Published online by Cambridge University Press:  07 October 2015

Xing-Jian Lin ,
Nian Yu ,
Xiao-Guang Lin ,
Yan-Fang Zhang ,
Yan Chen ,
Kang Zhang ,
Xiao-Shan Wang  and
Wei-Guo Liu
Xing-Jian Lin
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
Nian Yu
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
Xiao-Guang Lin
Affiliation:
Department of Neurology, Suqian People's Hospital, Jiangsu, China
Yan-Fang Zhang
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
Yan Chen
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
Kang Zhang
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
Xiao-Shan Wang
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
Wei-Guo Liu*
Affiliation:
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
*
Correspondence should be addressed to: Dr. Wei-Guo Liu, MD, Assistant Professor, Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China. Phone: +86-25-82296263; Fax: +86-25-83719457. E-mail: [email protected].
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Abstract

Background:

This is a case-control study to investigate the prevalence, characteristics, and risk factors of pain in patients with Parkinson's disease (PD).

Methods:

A total of 200 PD patients from eastern China were enrolled in our study. Accordingly, 200 healthy elderly adults were recruited as controls. The characteristics of pain were collected by using the Visual Analog Scale, Brief Pain Inventory (BPI), SF-36 Bodily Pain Scale, Unified Parkinson's Disease Rating Scale, Hoehn–Yahr Scale (H-Y), Hamilton Depression Scale, and Leeds Assessment of Neuropathic Symptoms and Signs.

Results:

Of the 200 PD patients, pain was complained by 106 patients (53%). According to the SF-36 Bodily Pain Scale, pain morbidity in PD patients was significantly higher than in the control group. The average pain during last 24 h measured by the BPI was 2.67. About 76% of PD patients were found to have one pain type, 21.7% were having two pain types, and 1.9% had three pain types. Further, 69.8% of these patients were presented with musculoskeletal pain, 4.7% with dystonic pain, 22.6% with radicular-neuropathic pain, 20.8% with central neuropathic pain, and 9.4% with akathisia pain. The onset age and depression were the most significant predictors of pain in PD patients (p < 0.05). However, there was no significant association between pain and gender, age, disease duration, or severity of the disease. Only 5.7% of PD patients with pain received treatment in this study.

Conclusions:

Pain is frequent and disabling, independent of demographic and clinical variables, and is significantly more common in PD patients.

Keywords

Parkinson's diseasepain disorderdepressionneuropathic painakathisia
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 2 , February 2016 , pp. 283 - 289
Copyright
Copyright © International Psychogeriatric Association 2015 

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References

Ashkan, K., Samuel, M., Reddy, P. and Chaudhuri, K. R. (2013). The impact of deep brain stimulation on the non-motor symptoms of Parkinson's disease. Journal of Neural Transmission, 120, 639–642.Google Scholar
Beiske, A. G., Loge, J. H., Rønningen, A. and Svensson, E. (2009). Pain in Parkinson's disease: prevalence and characteristics. Pain, 141, 173–177. doi:10.1016/j.pain.2008.12.004.Google Scholar
Blackburn-Munro, G. (2004). Hypothalamo-pituitary-adrenal axis dysfunction as a contributory factor to chronic pain and depression. Current Pain and Headache Reports, 8, 116–124.Google Scholar
Brefel-Courbon, C. et al. (2005). Effect of levodopa on pain threshold in Parkinson's disease: a clinical and positron emission tomography study. Movement disorders, 20, 1557–1563. doi:10.1002/mds.20629.CrossRefGoogle ScholarPubMed
Breivik, H., Collett, B., Ventafridda, V., Cohen, R. and Gallacher, D. (2006). Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. European Journal of Pain, 10, 287–287. doi:10.1016/j.ejpain.2005.06.009.CrossRefGoogle ScholarPubMed
Chaudhuri, K., Healy, D. G. and Schapira, A. H. (2006). Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurology, 5, 235–245. doi:10.1016/S1474-4422(06)70373-8.Google Scholar
Chou, K. L., Hurtig, H. I., Jaggi, J. L. and Baltuch, G. H. (2005). Bilateral subthalamic nucleus deep brain stimulation in a patient with cervical dystonia and essential tremor. Movement Disorders, 20, 377–380. doi:10.1002/mds.20341.Google Scholar
Csernansky, J. G. and Sheline, Y. I. (1993). Abnormalities of serotonin metabolism and non-psychotic psychiatric disorders. Annals of Clinical Psychiatry, 5, 275–281. doi:10.3109/10401239309148828.Google Scholar
Ehrt, U., Larsen, J. P. and Aarsland, D. (2009). Pain and its relationship to depression in Parkinson's disease. The American Journal of Geriatric Psychiatry, 17, 269–275. doi:10.1097/JGP.0b013e31818af7ef.Google Scholar
Fahn, S. and Elton, R. L. (1987). Members of the UPDRS Development Committee: unified Parkinson's disease rating scale. In: Fahn, S., Marsden, C. D., Calne, D. B. and Lieberman, A. (eds.), Recent Developments in Parkinson's Disease (pp. 153–163). Florham Park, NJ: MacMillan Health Care Information.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198. doi:http://dx.doi.org/10.1016/0022-3956(75)90026-6.Google Scholar
Ford, B. (1998). Pain in Parkinson's disease. Clinical Neuroscience (New York), 5, 63–72.Google Scholar
Gerdelat-Mas, A. et al. (2007). Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study. Journal of Neurology, Neurosurgery and Psychiatry, 78, 1140–1142. doi:10.1136/jnnp.2007.120212.Google Scholar
Goetz, C. G., Tanner, C. M., Levy, M., Wilson, R. S. and Garron, D. C. (1986). Pain in Parkinson's disease. Movement Disorders, 1, 45–49.Google Scholar
Ha, A. D. and Jankovic, J. (2012). Pain in Parkinson's disease. Movement Disorders, 27, 485–491. doi:10.1002/mds.23959.Google Scholar
Hess, C. and Ford, B. (2013). Pain in Parkinson's disease: pathophysiology, classification, and clinical approach. In: R. F. Pfeiffer and I. Bodis-Wollner (eds) Parkinson's Disease and Nonmotor Dysfunction (pp. 349–364). New York, NY: Humana Press.CrossRefGoogle Scholar
Jankovic, J. (2008). Parkinson's disease: clinical features and diagnosis. Journal of Neurology, Neurosurgery and Psychiatry, 79, 368–376.Google Scholar
Klepstad, P., Loge, J. H., Borchgrevink, P. C., Mendoza, T. R., Cleeland, C. S. and Kaasa, S. (2002). The Norwegian brief pain inventory questionnaire: translation and validation in cancer pain patients. Journal of Pain and Symptom Management, 24, 517–525. doi:10.1016/S0885-3924(02)00526-2.Google Scholar
Lee, M. A., Walker, R. W., Hildreth, T. J. and Prentice, W. M. (2006). A survey of pain in idiopathic Parkinson's disease. Journal of Pain and Symptom Management, 32, 462–469. doi:10.1016/j.jpainsymman.2006.05.020.Google Scholar
Li, L., Wang, H. and Shen, Y. (2003). Chinese SF-36 Health Survey: translation, cultural adaptation, validation, and normalisation. Journal of Epidemiology and Community Health, 57, 259–263. doi:10.1136/jech.57.4.259.Google Scholar
Lindvall, O. L., Björklund, A. B. and Skagerberg, G. (1983). Dopamine-containing neurons in the spinal cord: anatomy and some functional aspects. Annals of Neurology, 14, 255–260. doi:10.1111/j.1365-2044.1959.tb02431.x.Google Scholar
Loge, J. H. and Kaasa, S. (1998). Short form 36 (SF-36) Health Survey: normative data from the general Norwegian population. Scandinavian Journal of Public Health, 26, 250–258. doi:10.1177/14034948980260040401.Google Scholar
Quittenbaum, B. H. and Grahn, B. (2004). Quality of life and pain in Parkinson's disease: a controlled cross-sectional study. Parkinsonism and Related Disorders, 10, 129–136. doi:http://dx.doi.org/10.1016/j.parkreldis.2003.12.001.Google Scholar
Scherder, E., Wolters, E., Polman, C., Sergeant, J. and Swaab, D. (2005). Pain in Parkinson's disease and multiple sclerosis: its relation to the medial and lateral pain systems. Neuroscience and Biobehavioral Reviews, 29, 1047–1056. doi:10.1016/j.neubiorev.2005.03.001.Google Scholar
Schestatsky, P. et al. (2007). Neurophysiologic study of central pain in patients with Parkinson disease. Neurology, 69, 2162–2169.Google Scholar
Vu, T. C., Nutt, J. G. and Holford, N. H. (2012). Disease progress and response to treatment as predictors of survival, disability, cognitive impairment and depression in Parkinson's disease. British Journal of Clinical Pharmacology, 74, 284–295. doi:10.1111/j.1365-2125.2012.04208.x.Google Scholar
Ware, J. E., Kosinski, M., Dewey, J. E. and Gandek, B. (2000). SF-36 Health Survey: Manual and Interpretation Guide. Lincoln, RI: Quality Metric.Google Scholar