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The association of traumatic brain injury with rate of progression of cognitive and functional impairment in a population-based cohort of Alzheimer's disease: the Cache County dementia progression study by Gilbert et al. Late effects of traumatic brain injury on dementia progression

Published online by Cambridge University Press:  03 September 2014

David J. Sharp
David J. Sharp*
Affiliation:
National Institute of Health (NIHR) Research Professor, The Computational, Cognitive and Clinical Neuroimaging Laboratory, 3rd Floor, Burlington Danes Building, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Email: [email protected]
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Extract

There is compelling evidence that traumatic brain injury (TBI) can trigger neurodegeneration, and that this is a major determinant of long-term outcome (Smith et al., 2013). A single significant injury such as a road traffic accident or exposure to a bomb blast can predispose an individual to Alzheimer's disease (AD), and here Gilbert and colleagues show for the first time that a history of TBI also alters the progression the disease.

Type
Commentary paper of the month
Information
International Psychogeriatrics , Volume 26 , Issue 10 , October 2014 , pp. 1591 - 1592
Copyright
Copyright © International Psychogeriatric Association 2014 

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References

Bonnelle, V. et al. (2012). Salience network integrity predicts default mode network function after traumatic brain injury. Proceedings of the National Academy of Sciences of the United States of America, 109, 4690–4695.Google Scholar
Hong, Y. T. et al. (2014). Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurology, 71, 23–31.Google Scholar
Johnson, V. E., Stewart, J. E., Begbie, F. D., Trojanowski, J. Q., Smith, D. H. and Stewart, W. (2013). Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain, 136, 28–42.Google Scholar
Mayeux, R. et al. (1995). Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer’s disease. Neurology, 45, 555–557.CrossRefGoogle ScholarPubMed
McKee, A. C. et al. (2013). The spectrum of disease in chronic traumatic encephalopathy. Brain, 136, 43–64.CrossRefGoogle ScholarPubMed
Mielke, M. M. et al. (2011). Interaction between vascular factors and the APOE epsilon4 allele in predicting rate of progression in Alzheimer’s disease. Journal of Alzheimer's Disease, 26, 127–134.CrossRefGoogle ScholarPubMed
Ramlackhansingh, A. F. et al. (2011). Inflammation after trauma: microglial activation and traumatic brain injury. Annals of Neurology, 70, 374–383.Google Scholar
Rao, V. et al. (2010). Neuropsychiatric symptoms in dementia patients with and without a history of traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 22, 166–172.Google Scholar
Schmidt, M. L., Zhukareva, V., Newell, K. L., Lee, V. M. and Trojanowski, J. Q. (2001). Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer’s disease. Acta Neuropathologica, 101, 518–524.Google Scholar
Smith, D. H., Johnson, V. E. and Stewart, W. (2013). Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nature Reviews Neurology, 9, 211–221.Google Scholar