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3- Prevalence and impact of neuropsychiatric symptoms in normal aging and neurodegenerative syndromes: A population-based study from 6 Latin America centers. (Isaac Acosta)

Published online by Cambridge University Press:  27 November 2024

Isaac Acosta ,
Ana M. Rodriguez Salgado ,
Dani J. Kim ,
Jennifer Zitser ,
Ana Luisa Sosa ,
Daisy Acosta ,
Ivonne Z. Jimenez-Velasquez ,
Mariella Guerra ,
Aquiles Salas  and
Adolfo Valvuerdi
...Show all authors
Isaac Acosta
Affiliation:
Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico National Autonomous University of Mexico, Mexico City, Mexico
Ana M. Rodriguez Salgado
Affiliation:
Global Brain Health Institute, University of San Francisco California, San Francisco, California, USA
Dani J. Kim
Affiliation:
Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Jennifer Zitser
Affiliation:
Department of Neurology, Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Ana Luisa Sosa
Affiliation:
Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico National Autonomous University of Mexico, Mexico City, Mexico
Daisy Acosta
Affiliation:
Universidad Nacional Pedro Henriquez Ureña (UNPHU), Internal Medicine Department, Geriatric Section, Santo Domingo, Dominican Republic
Ivonne Z. Jimenez-Velasquez
Affiliation:
Internal Medicine Department, Geriatrics Program, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
Mariella Guerra
Affiliation:
Instituto de la Memoria Depresion y Enfermedades de Riesgo IMEDER, Lima, Perú
Aquiles Salas
Affiliation:
Medicine Department, Caracas University Hospital, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
Adolfo Valvuerdi
Affiliation:
Medical University of Matanzas, Matanzas, Cuba
Juan C. Llibre-Guerra
Affiliation:
Department of Neurology, Hospital de Salamanca, Salamanca, Spain
Christine Jeyachandran
Affiliation:
Faculty of Medicine and Health, University of New South Wales, Sydney, Australia
Ricardo López Contreras
Affiliation:
Memory Clinic, Neurology Service, Salvadoran Social Security Institute, San Salvador, El Salvador
Heike Hesse
Affiliation:
Universidad Tecnológica Centro americana, Tegucigalpa, Honduras
Caroline Tanner
Affiliation:
Department of Neurology, Weill Institute for Neurosciences, University of California-San Francisco, San Francisco, California, USA
Juan J. Llibre Rodriguez
Affiliation:
Facultad de Medicina Finlay-Albarran, Medical University of Havana, Havana, Cuba
Matthew Prina
Affiliation:
Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK
Jorge J. Llibre-Guerra
Affiliation:
Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA
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Abstract

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Objectives: Because of the continued transition to older populations, various strategies have been developed to estimate the social impact and burden of health care. Regarding mental health, a strategy in the elderly is the measurement of neuropsychiatric symptoms (NPS), these include a wide range of behavioral and psychological manifestations. These are more frequent in the presence of some diseases, such as neurodegenerative syndromes, among which dementias and Parkinson’s disease (PD) stand out. The present study seeks to analyze the frequency of NPS, its relationship with the presence or absence of neurodegenerative syndromes and some characteristics of the elderly and caregivers.

Methods: This is an analysis of data from 12,865 elderly people evaluated within the protocols of the Dementia Research Group 10/66 in 6 Latin American countries (Cuba, Dominican Republic, Puerto Rico, Mexico, Venezuela and Peru). The presence or absence of parkinsonism, dementia and parkinsonism plus dementia (PDD) was identified through previously validated and published Methods. The NPS were assessed using the 12-symptom questionnaire version of the Neuropsychiatric Inventory. Other characteristics such as age, sex and education, in patients and caregivers; socioeconomic status, disability and comorbidities in the elderly; relationship with the elderly, needs and care-burden were assessed in careers.

Results: The most frequent symptoms were depression and sleep disorders in the four groups (without non-NDS neurodegenerative syndromes, parkinsonism, dementia and PDD, ranging from 23% to 49%. About a third of the elderly with parkinsonism, half of those with dementia, and 3 out of 5 of the elderly with PDD had 3 or more NPS. The odds ratios (OR) of each NPS measure by multivariate logistic regression models shown OR from 1.4 to 1.9 in the presence of parkinsonism; between 1.7 and 9.3 in the presence of dementia; and between 1.9 and 10.2 in the presence of PDD.

Conclusions: From a clinical and public mental health perspective, it is necessary to implement systematic Methods for NPS screening, as well as develop support strategies for families and caregivers, mainly of those with neurodegenerative syndromes.

Keywords

neuropsychiatric symptomsdementiasparkinsonismparkinsonism-dementiaLatin-Amer
Type
Symposia
Information
International Psychogeriatrics , Volume 36 , Issue S1 , September 2024 , pp. 19 - 20
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of International Psychogeriatric Association