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Challenges of clinical trials in low- and middle-income countries

Published online by Cambridge University Press:  02 January 2018

Akwasi Osei
Akwasi Osei*
Affiliation:
Ghana Health Service; Accra Psychiatric Hospital, Accra, Ghana, email [email protected]
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Clinical trials have been conducted almost wholly in high-income countries until recently, yet their results may not always be valid or applicable in middle- and low-income countries. Clinical trials are now, though, increasingly being done in less wealthy countries. While this is welcome, there is a need to ensure the profit motive does not override the benefits. Partnership with local counterparts while adhering to international standards should help to maintain high-quality output from clinical trials.

Type
Thematic papers
Information
International Psychiatry , Volume 9 , Issue 2 , May 2012 , pp. 30 - 31
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
Copyright © Royal College of Psychiatrists 2012

References

Federation of Indian Chambers of Commerce and Industry (2005) White Paper on Global Clinical Trials in India: Prospects and Challenges. FICCI.Google Scholar
Glickman, S. W., McHutchison, J. G., Peterson, E. D., et al (2009) Ethical and scientific implications of the globalization of clinical research. New England Journal of Medicine, 360, 816–823.CrossRefGoogle ScholarPubMed
Hyder, A. A., Wali, S. A., Khan, A. N., et al (2004) Ethical review of health research: a perspective from developing country researchers. Journal of Medical Ethics, 30, 68–72.CrossRefGoogle ScholarPubMed
Johnatty, R. N. (2000) Clinical trials in developing countries: discussions at the 9th International Symposium on Long Term Clinical Trials. Current Controlled Trials in Cardiovascular Medicine, 1, 55–58.CrossRefGoogle Scholar
Kent, D. M., Mwamburi Mkaya, D., Bennish, M. L., et al (2004) Clinical trials in sub-Saharan Africa and established standards of care: a systematic review of HIV, tuberculosis and malaria trials. JAMA, 292, 237–242.CrossRefGoogle ScholarPubMed
Krosin, M. T., Klitzman, R., Levin, B., et al (2006) Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa. Clinical Trials, 3, 306–313.CrossRefGoogle ScholarPubMed
Nekkanti, M. (2008) Clinical Trials in Developing Countries: Ethical Considerations. Knol. Available at http://knol.google.com/k/manalinekkanti/clinical-trials-in-developing-countries/1h1wfnf2oeoie/2 (accessed March 2012).Google Scholar
Rowland, C. (2004) Clinical trials seen shifting overseas. International Journal of Health Services, 34, 555–556.CrossRefGoogle ScholarPubMed
Stephens, J. (2009) Pfizer to pay $75 million to settle Nigerian Trovan drug-testing suit. Washington Post, 31 July. Available at http://www.washingtonpost.com/wp-dyn/content/article/2009/07/30/AR2009073001847.html (accessed April 2012).Google Scholar
Tollman, S. M., Bastian, H., Doll, R., et al (2001) What are the effects of the fifth revision of the Declaration of Helsinki? BMJ (Clinical Research Edition), 323, 1417–1423.CrossRefGoogle ScholarPubMed
World Press Review (2001) April issue (vol. 48, no. 4).Google Scholar
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