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Toxicity of chlordimeform to the tsetse fly Glossina morsitans

Published online by Cambridge University Press:  19 September 2011

R. W. Pimley
R. W. Pimley
Affiliation:
Tsetse Research Laboratory, School of Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS18 7DU, England
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Abstract

Chlordimeform (CDM), tested by topical application, was found to be toxic to both male and female tsetse with the maximum effect some 72 hr after treatment. Median lethal doses were approx. 0.4 μg/fly for unfed adult tsetse of both sexes, 100% mortality at 72 hr was achieved with 2 μg/fly. Mature fed females were less susceptible to chlordimeform, the median lethal dose for 72 hr being 12.5 μg/fly. High doses of chlordimeform depressed the weight of puparia from survivors, but had no effect upon fecundity. Sublethal doses caused a significant depression of feeding activity, but did not cause hyperactivity or disrupt fat body lipid reserves.

Résumé

Il a été montré que le chlordimeforme appliqué sur la peau des tsétsé males et femelles était toxique, avec un affect maximum 72 hr après le traitment. Les doses mortelles médianes étaient approximativement de 0.4 μg/mouche pour les mouches adultes des 2 sexes non-nourries, une mortalité de 100% était atteinte après 72 hr avec 2 μg/mouche. Les femelles mûres nourries étaient moins susceptibles au chlordimeforme, la dose médiane mortelle pour 72 hr étant 12.5 μg/mouche. Des doses fortes de chlordimeforme causaient une diminution du poids des chrysalides de mouches qui survivaient mais n'avaient aucun effet sur la fécondité. Des doses non-mortelles causaient une dimunution significative des activités alimentaire, mais ne causaient pas une hyperactivité ou une diminution de réserves de graisses dans le corps.

Keywords

FormamidineschlordimeformtsetseGlossina morsitansFormamidineschlordimeformetsétséGlossina morsitans
Type
Research Articles
Information
International Journal of Tropical Insect Science , Volume 7 , Issue 5 , October 1986 , pp. 663 - 666
Copyright
Copyright © ICIPE 1986

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References

REFERENCES

Abo-Khatwa, N. and Hollingworth, R. M. (1972) Chlordimeform: the relation of mitochondrial uncoupling to toxicity in the German cockroach. Life Sci. 11, 1181–1190.Google Scholar
Abo-Khatwa, N. and Hollingworth, R. M. (1973) Chlordimeform: uncoupling activity against rat liver mitochondria. Pestic. Biochem. Physiol. 3, 358–369.CrossRefGoogle Scholar
Aziz, S. A. and Knowles, C. O. (1973) Inhibition of monoamine oxidase by the pesticide chlordimeform and related compounds. Nature 242, 417–418.CrossRefGoogle ScholarPubMed
Beeman, R. W. and Matsumura, F. (1973) Chlordimeform: a pesticide acting upon amine regulatory mechanisms. Nature 242, 273–274.CrossRefGoogle ScholarPubMed
Beeman, R. W. and Matsumura, F. (1978) Formamidine pesticides—actions in insects and acarines. In Pesticide and Venom Neurotoxicity (Edited by Shankland, D. L., Hollingworth, R. M. and Smyth, T. Jr), pp. 179–188. Plenum Press, New York.CrossRefGoogle Scholar
Chinn, C., Pfister, W. R. and Yim, G. K. W. (1976) Local anaesthetic-like actions of the pesticide chlordimeform (CDM). Fedn Proc. Fedn Am. Socs exp. Biol. 35, 729.Google Scholar
Clarke, L. (1982) Factors affecting uptake and loss of diflubenzuron in the tsetse fly Glossina morsitans morsitans Westwood (Diptera: Glossinidae). Bull. ent. Res. 72, 511–522.CrossRefGoogle Scholar
Hadaway, A. B. (1972) Toxicity of insecticides to tsetse flies. Bull. Wld Hlth Org. 46, 353–362.Google ScholarPubMed
Hadaway, A. B., Barlow, F., Turner, C. R. and Flower, L. S. (1977) The search for new insecticides for tsetse fly control. Pestic. Sci. 8, 172–176.CrossRefGoogle Scholar
Hollingworth, R. M. (1976) Chemistry, biological activity and uses of formamidine pesticides. Environ. Hlth Perspect. 14, 57–69.Google Scholar
Hollingworth, R. M. and Murdock, L. L. (1980) Formamidine pesticides: octopamine like actions in a firefly. Science 208, 74–76.Google Scholar
Jordan, A. M., Trewern, M. A., Borkovec, A. B. and DeMilo, A. B. (1979) Laboratory studies on the potential of three insect growth regulators for control of the tsetse fly, Glossina morsitans morsitans Westwood (Diptera:Glossinidae). Bull. ent. Res. 69, 55–64.CrossRefGoogle Scholar
Langley, P. A. and Pimley, R. W. (1975) Quantitative aspects of reproduction and larval nutrition in Glossina morsitans Westwood (Diptera: Glossinidae) fed in vitro. Bull. ent. Res. 65, 129–142.CrossRefGoogle Scholar
Matsumura, F. and Beeman, R. W. (1976) Biochemical and physiological effects of chlordimeform. Environ. Hlth Perspect. 14, 72–82.Google Scholar
Maudlin, I., Green, C. and Barlow, F. (1981) The potential for insecticide resistance in Glossina (Diptera:Glossinidae)—an investigation by computer simulation and chemical analysis. Bull. ent. Res. 71, 691–702.CrossRefGoogle Scholar
Mews, A. R., Langley, P. A., Pimley, R. W. and Flood, M. E. T. (1977) Large scale rearing of tsetse flies (Glossina spp.) in the absence of a living host. Bull. ent. Res. 67, 119–128.CrossRefGoogle Scholar
Murakami, M. and Fukami, J. (1974) Effects of chlorphenamidine and its metabolites on HeLa cells. Bull. Environ. Contam. Toxic. 11, 184.CrossRefGoogle ScholarPubMed
Nathanson, J. A. and Hunnicutt, E. J. (1981) N-demethyl-chlordimeform. A potent partial agonist of octopamine-sensitive adenylate cyclase. Molec. Pharmac. 20, 68–75.Google Scholar
Orchard, I., Singh, G. T. P. and Loughton, B. G. (1982) Action of formamidine pesticides on octopamine receptors on locust fat body. Comp. Biochem. Physiol. 73C, 331–334.Google Scholar
Pimley, R. W. (1984) Effects of biogenic amines on fat cells of Glossina morsitans in vitro. J. Insect Physiol. 30, 587–590.CrossRefGoogle Scholar
Pimley, R. W. and Stafford, K. A. (1985) Octopamine distribution in the tsetse fly Glossina morsitans. Comp. Biochem. Physiol. 81C, 297–301.Google Scholar
Singh, G. J. P., Orchard, I. and Loughton, G. B. (1981) Octopamine-like action of formamidines on hormone release in the locust, Locusta migratoria. Pestic. Biochem. Physiol. 16, 249–255.CrossRefGoogle Scholar
Vlakhov, V. (1966) Influence of drug preparation no. 18 on the cardiovascular system. Nauch. Vissh. Med. Inst. Sophia 45, 51–59.Google ScholarPubMed
Wang, C. M., Narahashi, T. and Fukami, J. (1975) Mechanism of neuromuscular block by chlordimeform. Pestic. Biochem. Phsyiol. 5, 119–125.CrossRefGoogle Scholar
Watanabe, H., Tsuda, S. and Fukami, J. (1975) Effects of chlordimeform on rectus abdominus muscle of frog. Pestic. Biochem. Physiol. 5, 150–154.CrossRefGoogle Scholar
Yamamoto, D. and Fukami, J. (1976) Effect of chlordimeform on nerve-muscle system of the waxmoth Galleria mellonella. J. Insect Physiol. 22, 1511–1516.CrossRefGoogle Scholar