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Antiparasitic compounds from East African plants: Isolation and biological activity of anonaine, matricarianol, canthin-6-one and caryophyllene oxide

Published online by Cambridge University Press:  19 September 2011

F. Bettarini ,
G. E. Borgonovi ,
T. Fiorani ,
I. Gagliardi ,
V. Caprioli ,
P. Massardo ,
J. I. J. Ogoche ,
A. Hassanali ,
E. Nyandat  and
A. Chapya
F. Bettarini
Affiliation:
Istituto Guido Donegani S.p.A., Enimont Group, Via G. Fauser 4, 28100 Novara, Italy
G. E. Borgonovi
Affiliation:
Istituto Guido Donegani S.p.A., Enimont Group, Via G. Fauser 4, 28100 Novara, Italy
T. Fiorani
Affiliation:
Istituto Guido Donegani S.p.A., Enimont Group, Via G. Fauser 4, 28100 Novara, Italy
I. Gagliardi
Affiliation:
Istituto Guido Donegani S.p.A., Enimont Group, Via G. Fauser 4, 28100 Novara, Italy
V. Caprioli
Affiliation:
Agrimont S.r.l., Ricerca Fitofarmaci, Enimont Group, Via G. Fauser 4, 28100 Novara, Italy
P. Massardo
Affiliation:
Agrimont S.r.l., Ricerca Fitofarmaci, Enimont Group, Via G. Fauser 4, 28100 Novara, Italy
J. I. J. Ogoche
Affiliation:
The International Centre of Insect Physiology and Ecology, P. O. Box 30772, Nairobi, Kenya
A. Hassanali
Affiliation:
The International Centre of Insect Physiology and Ecology, P. O. Box 30772, Nairobi, Kenya
E. Nyandat
Affiliation:
The International Centre of Insect Physiology and Ecology, P. O. Box 30772, Nairobi, Kenya
A. Chapya
Affiliation:
The International Centre of Insect Physiology and Ecology, P. O. Box 30772, Nairobi, Kenya
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Abstract

Five natural compounds possessing antiparasitic activity were isolated from East African plants and tested, together with some semisynthetic derivatives, against micro-organisms and arthropods of agricultural interest. Anonaine (1), from Annona squamosa, canthin-6-one(8) and 5-methoxycanthin-6-one (9), from Fagaropsis angolensis, showed fungicidal activity. E,Z-matricarianol (4), from Hoehnelia vernonioides was fungicidal, Insecticidal and acarlcldal. Caryophyllene oxide (12), isolated from Uvaria sp., turned out to be insecticidal and antifeedant. Canthin-6-one (8) and its dihydroderivative 11 were the most effective antimicrobial compounds tested. The possibility ofusing some of the isolated compounds as leads for new synthetic chemicals is discussed.

Résumé

Cinq produits naturels ayant de l'activité antiparasitaire étaient isolés de plantes de1' Afrique Orientale et evalué, avec quelques dérivés semisynthétiques, contre des microrganismes et des arthropodes d'intérêt agricole. L'anonaine (1), isolée de 1'Annona squamosa, le cantin-6-one (8) et le 5-methoxycantin-6-one (9), isolés de la Fagaropsis angolensis, montraient de l'activité fongicide. L' E, Z-matricarianol (4), isolé de l'Hoehnelia vernonioides, se revelait fongicide, insectcide et acarcide. L'époxidede B-caryophylléne (12), isolé de 1' Uvaria sp., se réélalt insectcide et antiappetant Le cantin-6-one (8) et son dihldroderivé 11 étaient les plus actifs parmi les produits antimcrobiens évalues. On discute la possibilité d'utiliser quelques-uns des produits isolés commesouches de nouveaux produits synthétiques.

Keywords

Antiparasitic activityfungicidal activityinsecticidal activityanonaineAnnona squamosacanthin-6-oneFagaropsis angolensisZanthoxylum usambarensisE,Z-matricarianolHoehnelia vernonioidescaryophyllene oxideUvaria sp.
Type
Research Articles
Information
International Journal of Tropical Insect Science , Volume 14 , Issue 1 , February 1993 , pp. 93 - 99
Copyright
Copyright © ICIPE 1993

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