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Problems in the Use of Large Data Sets to Assess Effectiveness

Published online by Cambridge University Press:  10 March 2009

Robert Temple
Robert Temple
Affiliation:
U.S. Food and Drug Administration
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Abstract

Large data sets are an attractive source of information for outcome assessment, but their use involves certain problems and risks. Data base evaluations are retrospective and unblinded; they often represent the result of multiple analyses of multiple endpoints, and it is difficult to identify the procedures used and analytic choices made because critical details are often omitted. While data bases can suggest problems and offer answers, they cannot prove them; data base analyses must be followed by trials.

Type
Special Section: Measuring Health Care Effectiveness: Use of Large Data Bases for Technology and Quality Assessments
Information
International Journal of Technology Assessment in Health Care , Volume 6 , Issue 2 , January 1990 , pp. 211 - 219
Copyright
Copyright © Cambridge University Press 1990

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References

REFERENCES

1Alderman, M. H., Ooi, W. L., Medhaven, S., & Cohen, H.Treatment-induced blood pressure reduction and the risk of myocardial infarction. Journal of the American Medical Association, 1989, 262, 920–24.CrossRefGoogle ScholarPubMed
2Diehl, L. F., & Perry, D. J. Acomparison of randomized concurrent control groups with matched historical controls: Are historical controls valid? Journal of Clinical Oncology, 1986, 4, 114–20.CrossRefGoogle ScholarPubMed
3Gruppo Italiano per lo Studio della Streptochinasi nel Infarcto Miocardiaco. Report of the GRISSIM. Lancet, 1986, i, 397–402.Google Scholar
4Medical Research Council Working Party. MRC trial of treatment of mild hypertension: Principal results. British Medical Journal, 1985, 291, 97–104.CrossRefGoogle Scholar
5Roos, N. P., Wennberg, J. E., Malenka, D. J. et al. , Mortality and reoperation after open and transurethral hyperplasia. New England Journal of Medicine, 1989, 320, 1120–24.CrossRefGoogle ScholarPubMed
6Sacks, H., Chalmers, T. C., & Smith, H.Randomized versus historical controls for clinical trials. American Journal of Medicine, 1982, 72, 233–40.CrossRefGoogle ScholarPubMed