Hostname: page-component-669899f699-g7b4s Total loading time: 0 Render date: 2025-05-05T22:29:05.550Z Has data issue: false hasContentIssue false
  • English
  • Français

Prevention and Treatment of Postasphyxial Cerebral Damage

Published online by Cambridge University Press:  10 March 2009

Kari O. Raivio
Kari O. Raivio
Affiliation:
Children's Hospital, University of Helsinki
Get access Rights & Permissions [Opens in a new window]

Extract

Prevention and treatment of postasphyxial, i.e. hypoxic-ischemic, brain damage can be considered at various levels or stages of the process. The first approach is based on epidemiological studies, which typically allow the delineation of risk factors for cerebral damage. By trying to eliminate or reduce such factors, one may influence the incidence of the disorder. At the second stage, the actual pathogenetic mechanisms, e.g. hypoxia or hypotension, leading to brain damage may be preventable or treatable. Finally, limiting the extent of the lesion immediately after the event may be possible.

Type
Neonatal Disorders of the Central Nervous System
Information
International Journal of Technology Assessment in Health Care , Volume 7 , Supplement S1 , January 1991 , pp. 110 - 112
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

1.Ahdab-Barmada, M., Moossy, J., & Painter, M.Pontosubicular necrosis and hyperoxemia. Pediatrics, 1980, 66, 840–47.CrossRefGoogle ScholarPubMed
2.Chiswick, M. L., Johnson, M., Woodhall, C., Gowland, M., Davies, J., Toner, N., & Sims, D. G.Protective effect of vitamin E (DL-alpha-tocopherol) against intraventricular haemorrhage in premature babies. British Medical Journal, 1983, 287, 81–84.CrossRefGoogle ScholarPubMed
3.Cowan, F.Indomethacin, patent ductus arteriosus, and cerebral blood flow. Journal of Pediatrics, 1986, 109, 341–44.CrossRefGoogle ScholarPubMed
4.Kuban, K. K., Leviton, A., Krishnamoorthy, K. S., Brown, E. R., Littlewood Teele, R., Baglivo, J. A., Sullivan, K. F., Huff, K. R., White, S., Cleveland, R. H., Allred, E. N., Spritzer, K. L., Skouteli, H. N., Cayea, P., & Epstein, M. F.Neonatal intracranial hemorrhage and phenobarbital therapy. Pediatrics, 1986, 77, 443-50.CrossRefGoogle Scholar
5.Levene, M. I., & Evans, D. H.Medical management of raised intracranial pressure after severe birth asphyxia. Archives of Disease in Childhood, 1985, 60, 12–15.CrossRefGoogle ScholarPubMed
6.McDonald, J. W., Silverstein, F. S., & Johnston, M. V.MK-801 protects the neonatal brain from hypoxic-ischemic damage. European Journal of Pharmacology, 1987, 140, 359–61.CrossRefGoogle ScholarPubMed
7.Ment, L. R., Duncan, C. C., Ehrenkranz, R. A., et al. Randomized indomethacin trial for the prevention of intraventricular hemorrhage in very low birth weight neonates. Journal of Pediatrics, 1985, 107, 937–43.CrossRefGoogle Scholar
8.Morgan, M. E. I., Benson, J. W. T., & Cooke, R. W. I.Ethamsylate reduces the incidence of periventricular haemorrhage in very low birthweight babies. Lancet, 1981, ii, 830–32.CrossRefGoogle Scholar
9.Perlman, J. M., Goodman, S., Kreusser, K. L., & Volpe, J. J.Reduction in intraventricular hemorrhage by elimination of fluctuating cerebral blood-flow velocity in preterm infants with respiratory distress syndrome. New England Journal of Medicine, 1985, 312,1353–1357.CrossRefGoogle ScholarPubMed
10.Perlman, J. M., McMenamin, J. B., & Volpe, J. J.Fluctuating cerebral blood-flow velocity in respiratory distress syndrome. New England Journal of Medicine, 1983, 309, 204–09.CrossRefGoogle ScholarPubMed
11.Ruth, V., Virkola, K., Paetau, R., & Raivio, K. O.Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants. Journal of Pediatrics, 1988, 112, 81–86.CrossRefGoogle ScholarPubMed
12.Shankaran, S., Cepeda, E. E., Ilagan, N., Mariona, F., Hassan, M., Bhatis, R., Ostrea, E., Bedard, M. P., & Poland, R. L.Antenatal phenobarbital for the prevention of neonatal intracerebral hemorrhage. American Journal of Obstetrics and Gynecology, 1986, 154, 53–57.CrossRefGoogle ScholarPubMed
13.Szymonowicz, W., Yu, V. Y. H., Walker, A., & Wilson, F.Reduction in periventricular haemorrhage in preterm infants. Archives of Disease in Childhood, 1986, 61, 661–65.CrossRefGoogle ScholarPubMed
14.Thiringer, K., Hrbek, A., Karlsson, K., Rosén, K.-G., & Kjellmer, I.Postasphyxial cerebral survival in newborn sheep after treatment with oxygen free radical scavengers and a calcium antagonist. Pediatric Research, 1987, 22, 62–66.CrossRefGoogle Scholar