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Persistent Pulmonary Hypertension of the Newborn

Published online by Cambridge University Press:  10 March 2009

George Lister
George Lister
Affiliation:
Yale University School of Medicine
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Extract

Persistent pulmonary hypertension of the newborn or persistent fetal circulation is a clinical syndrome that is usually apparent within the first 2 days after birth because of the presence of hypoxemia (2;12;19). The syndrome was first described in an abstract by Gersony, Due, and Sinclair (6) in 1969. Two infants were reported who had “RV decompensation, cyanosis and clear lung fields… in the absence of recognizable cardiac, pulmonary, hematologic or CNS disease.” The syndrome has been associated with aspiration of meconium, diaphragmatic hernia, asphyxia, hemorrhage, shock, and maternal infection (4;18). In other cases, there is no clear antecedent event. Despite considerable interest in the problem and a wealth of research related to pulmonary vasoregulation and vascular development in the fetus and newborn, the etiology of the syndrome remains obscure 20 years since its recognition.

Type
Neonatal Disorders of Circulation
Information
International Journal of Technology Assessment in Health Care , Volume 7 , Supplement S1 , January 1991 , pp. 66 - 69
Copyright
Copyright © Cambridge University Press 1991

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References

REFERENCES

1.Drummond, W. H., Peckham, G. J., & Fox, W. W.The clinical profile of the newborn with persistent pulmonary hypertension. Clinics in Perinatology, 1977, 16, 335–41.Google ScholarPubMed
2.Drummond, W. H., Gregory, G. A., Heymann, M. A., & Phibbs, R. A.The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. Journal of Pediatrics, 1981, 98, 603–11.CrossRefGoogle ScholarPubMed
3.Geggel, R. L., & Reid, L. M.The structural basis of PPHN. Clinics in Perinatology, 1984, 11, 525–49.CrossRefGoogle ScholarPubMed
4.Gersony, W. M.Persistence of the fetal circulation: A commentary (editorial). Journal of Pediatrics, 1973, 82, 1103.CrossRefGoogle Scholar
5.Hansen, T. N., & Gest, A. L.Oxygen toxicity and other ventilatory complications of treatment of infants with persistent pulmonary hypertension. Clinics in Perinatology, 1984, 11, 653–72.CrossRefGoogle ScholarPubMed
6.Gersony, W. M., Due, G. V., & Sinclair, J. C.“PFC” syndrome (persistence of the fetal circulation). Circulation, 1969, 40 (Suppl. 111–87).Google Scholar
7.Gersony, W. M.Neonatal pulmonary hypertension: Pathophysiology, classification, and etiology. Clinics in Perinatology, 1984, 11, 517–524.CrossRefGoogle Scholar
8.Goetzman, B. W., Sunshine, P., Johnson, J. D., Weenberg, R. P., Hackel, A., Merten, D. F., Bartoletti, A. L., & Silverman, N. H.Neonatal hypoxia and pulmonary vasospasm: response to tolazoline. Journal of Pediatrics, 1976, 89, 617–21.CrossRefGoogle ScholarPubMed
9.Harrison, M. R., Jester, J. A., & Ross, N. A.Correction of congenital diaphragmatic hernia in utero. I. The model: Intrathoracic balloon produces fetal pulmonary hypoplasia. Surgery, 1980, 88, 174–82.Google Scholar
10.Hu, L.-M., Davies, P., Adzick, N. S., Harrison, M. R., & Reid, L. M.The effects of intrauterine pneumonectomy in lambs. American Review of Respiratory Disease, 1987,135, 607–12.Google ScholarPubMed
11.Kulik, T. J., & Lock, J. E.Pulmonary vasodilator therapy in persistent pulmonary hypertension of the newborn. Clinics in Perinatology, 1984, 11, 693–701.CrossRefGoogle ScholarPubMed
12.Levin, D. L., Mills, L. J., & Weinberg, A. G.Hemodynamic, pulmonary vascular, and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus. Circulation, 1979, 60, 360–364.CrossRefGoogle ScholarPubMed
13.Levin, D. L., Heymann, M. A., Kitterman, J. A., Gregory, G. A., Phibbs, R. H., & Rudolph, A. M.Persistent pulmonary hypertension of the newborn infant. Journal of Pediatrics, 1976, 89, 626–30.CrossRefGoogle ScholarPubMed
14.Levin, D. L., Hyman, A. I., Heymann, M. A., & Rudolph, A. M.Fetal hypertension and the development of increased pulmonary vascular smooth muscle: A possible mechanism for persistent pulmonary hypertension of the newborn infant. Journal of Pediatrics, 1978, 92, 265–269.CrossRefGoogle ScholarPubMed
15.Long, W. A.Structural cardiovascular abnormalities presenting as persistent pulmonary hypertension of the newborn. Clinics in Perinatology, 1984, 11, 601–26.CrossRefGoogle ScholarPubMed
16.Lyrene, R. K., & Philips, J. B. III.Control of pulmonary vascular resistance in the fetus and newborn. Clinics in Perinatology, 1984, 11, 551–564.CrossRefGoogle ScholarPubMed
17.Meyrick, B., & Reid, L.Development of pulmonary arterial changes in rats fed Crotalaria spectabilis. American Journal of Pathology, 1979, 94, 37–50.Google ScholarPubMed
18.Reece, E. A., Moya, F., Yazigi, R., Holford, T., Duncan, C., & Ehrenkranz, R. A.Persistent pulmonary hypertension: Assessment of perinatal risk factors. Obstetrics and Gynecology, 1987, 70, 696–700.Google ScholarPubMed
19.Siassi, B., Goldberg, S. J., Emmanoulides, G. C., & Higashino, S. M.Persistent pulmonary vascular obstruction in newborn infants. Journal of Pediatrics, 1971, 78, 610.CrossRefGoogle ScholarPubMed
20.Wung, J.-T., James, L. S., Kilchevsky, E., & James, E.Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics, 1985, 76, 488–94.CrossRefGoogle ScholarPubMed