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Modern Concepts in Immune Recognition and Lymphocyte Activation: Relevance for the Development of Useful Vaccines

Published online by Cambridge University Press:  14 October 2009

Ronald N. Germain
Ronald N. Germain
Affiliation:
National Institute of Allergy and Infectious Diseases
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Abstract

Adaptive immunity requires both specific recognition of an antigen and its translation into appropriate lymphocyte responses. This paper reviews the striking differences in B- and T-lymphocyte antigen recognition, details the pathways for conversion of protein antigens into peptide–major histocompatibility complex molecule ligands for T-cell receptors, and summarizes the roles of costimulatory signals in lymphocyte activation. This information is used to suggest new approaches for the rational design of vaccines.

Type
Special Section: Vaccines and Public Health: Assessing Technologies and Public Policies
Information
International Journal of Technology Assessment in Health Care , Volume 10 , Issue 1 , Winter 1994 , pp. 81 - 92
Copyright
Copyright © Cambridge University Press 1994

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