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A Model for Evaluating the Cost-Effectiveness of Cholesterol-Lowering Treatment

Published online by Cambridge University Press:  10 March 2009

Henry Glick ,
Joseph F. Heyse ,
David Thompson ,
Robert S. Epstein ,
M. Eugene Smith  and
Gerry Oster
Henry Glick
Affiliation:
University of Pennsylvania
Joseph F. Heyse
Affiliation:
Merck Laboratories
David Thompson
Affiliation:
Policy Analysis Inc.
Robert S. Epstein
Affiliation:
University of Maryland and Merck Research Laboratories
M. Eugene Smith
Affiliation:
Merck & Co.Inc.
Gerry Oster
Affiliation:
Policy Analysis Inc.
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Abstract

We describe and illustrate the use of a generalizable model for evaluating the cost-effectiveness of alternative cholesterol-lowering treatments. We combine standard incidence-based techniques for measuring the cost of illness with logistic risk functions from the Framingham Heart Study to project, for persons with known coronary risk characteristics, the likelihood of developing coronary heart disease (CHD) over a lifetime as well as a number of related outcomes, including the expected loss of years of life due to CHD, the expected lifetime direct and indirect costs of CHD, and the changes in these outcomes that would result from cholesterol-lowering treatment.

Type
General Essays
Information
International Journal of Technology Assessment in Health Care , Volume 8 , Issue 4 , Fall 1992 , pp. 719 - 734
Copyright
Copyright © Cambridge University Press 1992

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