Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-05T11:09:01.624Z Has data issue: false hasContentIssue false
  • English
  • Français

Methylphenidate delivery mechanisms for the treatment of children with attention deficit hyperactivity disorder: Heterogeneity in parent preferences

Published online by Cambridge University Press:  08 July 2011

Andrew Lloyd ,
Paul Hodgkins ,
Sarah Dewilde ,
Rahul Sasané ,
Shona Falconer  and
Edmund Sonuga Barke
Andrew Lloyd
Affiliation:
Oxford Outcomes Ltd
Paul Hodgkins
Affiliation:
Shire Pharmaceuticals Ltd.
Sarah Dewilde
Affiliation:
Oxford Outcomes Ltd
Rahul Sasané
Affiliation:
Shire Pharmaceuticals Ltd.
Shona Falconer
Affiliation:
Oxford Outcomes Ltd
Edmund Sonuga Barke
Affiliation:
University of Southampton and Ghent University
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives: Extended-release therapies avoid the need for children with attention-deficit/hyperactivity disorder (ADHD) to take medication at school. Recently a transdermal delivery system has been developed which can allow symptom control all day long but with greater dosing flexibility. This study explored the parents' preferences regarding oral and transdermal therapy.

Methods: A nonsystematic and qualitative literature review and in-depth interviews with parents and physicians helped identify salient treatment attributes for a discrete choice experiment. Treatment attributes included mode of administration (tablet or transdermal), speed of onset (30–90 min); duration (lasts until 3–9 pm) and ability to tailor the drug to different needs (no flexibility, limited flexibility, easy to adjust to different days). A convenience sample of parents of children treated for ADHD (n = 200) were recruited using a recruitment agency. Data were analyzed using generalized estimating equations (GEE).

Results: Parents' preferred once-a-day oral therapy (odds ratio [OR] = 1.76 [95 percent confidence interval {CI}, 1.43 – 2.18]); rapid speed of onset (OR = 1.22 [95 percent CI, 1.07 – 1.39]), and symptom control until 9 pm (OR = 3.79 [95 percent CI, 2.98 – 4.82]). Analyses identified that 30 percent of parents preferred transdermal treatment and this subgroup preferred treatments with a fast onset of action.

Conclusions: This survey demonstrates that parents of ADHD children have different preferences for the ADHD treatments prescribed for their children. A distinct subgroup of parents prefer the transdermal therapy. These parents were less likely to be working and so monitoring compliance and doing after school activities may have been easier.

Keywords

Attention-deficit hyperactivity disorderPatient preferenceTransdermal administration
Type
ASSESSMENTS
Information
International Journal of Technology Assessment in Health Care , Volume 27 , Issue 3 , July 2011 , pp. 215 - 223
Copyright
Copyright © Cambridge University Press 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. American Academy of Pediatrics. Clinical practice guideline: Treatment of the school-aged child with attention-deficit hyperactivity disorder. Pediatrics. 2001;108:1033–1044.CrossRefGoogle Scholar
2. Barkley, RA, McMurray, MB, Edelbrock, CS, Robbins, K. Side effects of methylphenidate in children with attention deficit hyperactivity disorder. A systemic, placebo-controlled evaluation. Pediatrics. 1990;86:184–192.CrossRefGoogle ScholarPubMed
3. Biederman, J, Faraone, SV. The effects of attention-deficit/hyperactivity disorder on employment and household income. Med Gen Med. 2006;18;8:12.Google Scholar
4. Bridges, J, Hauber, BA, Marshall, D, et al. . Conjoint analysis applications in health - A checklist: A report of the ISPOR Good Research Practices for Conjoint Analysis Task Force. Value Health. In press.Google Scholar
5. Cunningham, CE, Deal, K, Rimas, H, et al. Modeling the information preferences of parents of children with mental health problems: A discrete choice conjoint experiment. J Abnorm Child Psychol. 2008;36:1123–1138.CrossRefGoogle ScholarPubMed
6. Greater Manchester Interface Prescribing Group Shared Care Guideline. Methylphenidate and Dexamfetamine for childhood and adolescent attention deficit hyperactivity disorder (ADHD). Manchester: Greater Manchester Medicines Management Group; November 2006.Google Scholar
7. Greenhill, LL, Findling, RL, Swanson, JM. A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorder. Pediatrics. 2002;109:e39.CrossRefGoogle ScholarPubMed
8. Hedeker, D, Gibbons, RD. Generalized Estimating Equations (GEE) Models. In: Hedeker, D, Gibbons, RD, eds. Longitudinal data analysis. Chichester, UK: John Wiley & Sons; 2006.Google Scholar
9. ICC/ESOMAR International Code On Market And Social Research, www.esomar.org, 2007.Google Scholar
10. Kendall, J, Hatton, D, Beckett, A, Leo, M. Children's accounts of attention-deficit/hyperactivity disorder. ANS Adv Nurs Sci. 2003;26:114–130.CrossRefGoogle ScholarPubMed
11. Marcus, SC, Wan, GJ, Kemner, JE, Olfson, M. Continuity of methylphenidate treatment for attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2005;159:572–578.CrossRefGoogle ScholarPubMed
12. McGough, JJ, Wigal, SB, Abikoff, J, et al. A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD. J Atten Disord. 2006;9:476–485.CrossRefGoogle ScholarPubMed
13. Meaux, JB, Hester, C, Smith, B, Shoptaw, A. Stimulant medications: A Trade-off? The lived experience of adolescents with ADHD. J Spec Pediatr Nurs. 2006;11:214–226.CrossRefGoogle ScholarPubMed
14. Mühlbacher, AC, Rudolph, I, Lincke, HJ, Nübling, M. Preferences for treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A discrete choice experiment. BMC Health Serv Res. 2009;13:9:149.CrossRefGoogle Scholar
15. National Institute for Health and Clinical Excellence. Attention deficit hyperactivity disorder: Diagnosis and management of ADHD in children, young people and adults. 2008. http://www.nice.org.uk/Guidance/CG72/ (accessed January 2010).Google Scholar
16. National Institute for Health and Clinical Excellence (NICE). Medicines adherence Involving patients in decisions about prescribed medicines and supporting adherence NICE clinical guideline 76. Issue date: January 2009. Developed by the National Collaborating Centre for Primary Care.Google Scholar
17. National Institute for Health and Clinical Excellence (NICE). Methylphenidate, atomoxetine and dexamfetamine for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Review of Technology Appraisal 13. London: NICE; March, 2006.Google Scholar
18. Nixon, G, Richardson, R. Attention Deficit Hyperactivity Disorder (ADHD) A Practical Guide For Schools ADHD Working Group June 2004; www.belb.org.uk (accessed October 2009).Google Scholar
19. Pelham, WE, Foster, EM, Robb, JA. The economic impact of attention-deficit/hyperactivity disorder in children and adolescents. J Pediatr Psychol. 2007;32:711–727.CrossRefGoogle ScholarPubMed
20. Preuss, U, Ralston, SJ, Baldursson, G, et al., and ADORE Study Group. Study design, baseline patient characteristics and intervention in a cross-cultural framework: Results from the ADORE study. Eur Child Adolesc Psychiatry. 2006;15 (Suppl 1):I/4–I/14.CrossRefGoogle Scholar
21. Ryan, M, Gerard, K. Using discrete choice experiments to value health care programmes: Current practice and future research reflections. Appl Health Econ Health Policy. 2003;2:55–64.Google ScholarPubMed
22. Sanchez, RJ, Crismon, ML, Barner, JC, Bettinger, T, Wilson, JP. Assessment of adherence measures with different stimulants among children and adolescents. Pharmacotherapy. 2005;25:909–917.CrossRefGoogle ScholarPubMed
23. Scottish Intercollegiate Guidelines Network. Attention deficit and hyperkinetic disorders in children and young people. Clinical guideline 52. Edinburgh: Scottish Intercollegiate Guidelines Network; 2001.Google Scholar
24. Taylor, E, Döpfner, M, Sergeant, J, et al. European clinical guidelines for hyperkinetic disorder – first upgrade. Eur Child Adolesc Psychiatry. 2004;13 (Suppl 1):I7–I30.CrossRefGoogle ScholarPubMed
25. Taylor, EA, Sonuga-Barke, EJS. Disorders of attention and activity. In: Rutter, M, Bishop, D, Pine, D, et al. , eds. Rutter's child & adolescent psychiatry. 2nd ed. UK: Wiley-Blackwell; 2008:521–542.Google Scholar
26. Tees and NE Yorkshire NHS Trust, Hartlepool PCT, Middlesbrough PCT, Stockton PCT, and Redcar and Cleveland PCT. Shared care pilot protocol stimulant medication for treatment of attention deficit hyperactivity disorder for patients under 18 years. nww.rcpct.nhs.uk (accessed July 2004).Google Scholar
Supplementary material: File

Lloyd et al. supplementary material

Supplementary Table 1

Download Lloyd et al. supplementary material(File)
File 59.9 KB