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Health-related quality of life in elderly patients with familial hypercholesterolemia

Published online by Cambridge University Press:  09 April 2008

Laura Hyttinen
Affiliation:
North Karelia Central Hospital
Päivi Kekäläinen
Affiliation:
North Karelia Central Hospital
Alpo F. Vuorio
Affiliation:
University of Helsinki (University Hospital of Helsinki)
Harri Sintonen
Affiliation:
University of Helskinki and Finnish Office for Health Technology Assessment, STAKES
Timo E. Strandberg
Affiliation:
University of Oulu and Oulu University Hospital

Abstract

Objectives: There are very few descriptions on how familial hypercholesterolemia (FH), a genetic disorder with an increased risk of coronary heart disease (CHD), affects older patients. The aim of this study was to analyze the health-related quality of life (HRQoL) of elderly patients with FH.

Methods: All FH patients with the same FH North Karelia-mutation aged 65 and over living in North Karelia province in Eastern Finland were asked to participate in the study in 2003. They were compared with age-standardized controls from the Finnish general population. A total of forty-three elderly FH patients were identified and thirty-seven of them (aged 65 to 84 years, M/F 10/27) agreed to participate. Most of them (27/37) had been diagnosed with CHD. All but one of these FH patients had been using statins for approximately 15 years. HRQoL was assessed with the RAND-36 (SF-36) and 15D instruments.

Results: Despite the clear cardiovascular morbidity and low socioeconomic status, these FH patients enjoyed a similar HRQoL as the age-standardized controls in the general population.

Conclusions: Lifelong hypercholesterolemia was not associated with poorer HRQoL in elderly survivors of FH. These elderly FH individuals were characterized by their healthy lifestyle and long-term statin treatment.

Type
GENERAL ESSAYS
Copyright
Copyright © Cambridge University Press 2008

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References

REFERENCES

1. Aalto, A-M, Aro, AR, Teperi, J. RAND-36 as a measure of health-related quality of life. Reliability, construct validity, and reference values in the Finnish general population. Helsinki: Stakes, Research Reports 101; 1999 (in Finnish).Google Scholar
2. Aromaa, A, Koskinen, S, eds. Health and functional capacity in Finland. Baseline results of the Health2000 health examination survey. Publications of the National Public Health Institute B3/2002. Helsinki: National Public Health Institute; 2002 (in Finnish).Google Scholar
3. Bardage, C, Isacson, DGL. Hypertension and health-related quality of life: An epidemiological study in Sweden. J Clin Epidemiol. 2001;54:172181.CrossRefGoogle ScholarPubMed
4. Brezinka, V, Kittel, F. Psychosocial factors of coronary heart disease in women: A review. Soc Sci Med. 1996;42:13511365.CrossRefGoogle ScholarPubMed
5. Brown, N, Melville, M, Gray, D, et al. Quality of life four years after acute myocardial infarction: Short form 36 scores compared with a normal population. Heart. 1999;81:352358.CrossRefGoogle ScholarPubMed
6. De Jongh, S, Kerckhoffs, MC, Grootenhuis, MA, et al. Quality of life, anxiety and concerns among statin-treated children with familial hypercholesterolemia and their parents. Acta Paediatr. 2003;92:10961101.Google Scholar
7. Duncan, PW, Samsa, GP, Weinberger, M, et al. Health status of individuals with mild stroke. Stroke. 1997;28:740745.Google Scholar
8. Goldstein, JL, Hobbs, HH, Brown, MS. Familial hypercholesterolemia. In: Scriver, CR, Beaudet, AL, Sly, WS, et al. eds. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill; 2001:28632913.Google Scholar
9. Gulliford, MC, Mahabir, D. Relationship of health-related quality of life to symptom severity in diabetes mellitus: A study in Trinidad and Tobago. J Clin Epidemiol. 1999;52:773780.Google Scholar
10. Hemingway, H, Nicholson, A, Stafford, M, Roberts, R, Marmot, M. The impact of socioeconomic status on health functioning as assessed by the SF-36 questionnaire: The Whitehall II Study. Am J Public Health. 1997;87:14841490.Google Scholar
11. Hollman, G, Gullberg, M, Ek, A-C, Eriksson, M, Olsson, AG. Quality of life in patients with familial hypercholesterolemia. J Intern Med. 2002;251:331337.CrossRefGoogle Scholar
12. Lyons, RA, Lo, SV, Littlepage, BN. Comparative health status of patients with 11 common illnesses in Wales. J Epidemiol Community Health. 1994;48:388390.CrossRefGoogle ScholarPubMed
13. Regidor, E, Barrio, G, de la Fuente, L, et al. Association between educational level and health related quality of life in Spanish adults. J Epidemiol Commun Health. 1999;53:7582.Google Scholar
14. Retterstol, K, Stugaard, M, Gorbitz, C, Ose, L. Results of intensive long-term treatment of familial hypercholesterolemia. Am J Cardiol. 1996;78:13691374.Google Scholar
15. Scientific Steering Committee on behalf of the Simon Broome Register Group. Mortality in treated heterozygous familial hypercholesterolaemia: Implications for clinical management. Atherosclerosis. 1999;142:105112.Google Scholar
16. Sintonen, H. The 15D instrument of health-related quality of life: Properties and applications. Ann Med. 2001;33:328336.CrossRefGoogle ScholarPubMed
17. Soljanlahti, S, Autti, T, Lauerma, K, et al. Familial hypercholesterolemia patients treated with statins at no increased risk for intracranial vascular lesions despite increased cholesterol burden and extracranial atherosclerosis. Stroke. 2005;36:15721574.Google Scholar
18. Soto, M, Failde, I, Marquez, S, et al. Physical and mental component summaries score of the SF-36 in coronary patients. Qual Life Res. 2005;14:759768.Google Scholar
19. Sprangers, MAG, de Regt, EB, Andries, F, et al. Which chronic conditions are associated with better or poorer quality of life? J Clin Epidemiol. 2000;53:895907.Google Scholar
20. Strandberg, TE, Strandberg, A, Rantanen, K, et al. Low cholesterol, mortality, and quality of life in old age during a 39-year follow-up. J Am Coll Cardiol. 2004;44:10021008.Google Scholar
21. Torres, MS, Calderon, SM, Diaz, IR, et al. Health-related quality of life in coronary heart disease compared to norms in Spanish population. Qual Life Res. 2004;13:14011407.CrossRefGoogle Scholar
22. Van Jaarsveld, CHM, Sanderman, R, Ranchor, AV, et al. Gender-specific changes in quality of life following cardiovascular disease: A prospective study. J Clin Epidemiol. 2002;55:11051112.CrossRefGoogle ScholarPubMed
23. Vuorio, AF, Turtola, H, Piilahti, K-M, et al. Familial hypercholesterolemia in the Finnish North Karelia. A molecular, clinical and genealogical study. Arterioscler Thromb Vasc Biol. 1997;17:31273138.CrossRefGoogle ScholarPubMed
24. Westin, L, Carlsson, R, Erhardt, L, Cantor-Graae, E, McNeil, T. Differences in quality of life in men and women with ischemic heart disease. A prospective controlled study. Scand Cardiovasc J. 1999;33:160165.Google Scholar