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Gene Therapy: Molecular Medicine of the 1990s

Published online by Cambridge University Press:  10 March 2009

Nelson A. Wivel
Nelson A. Wivel
Affiliation:
U.S. National Institutes of Health
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Abstract

In less than four years, the techniques of gene transfer have been taken from the laboratory and translated into numerous clinical trials. Although gene therapy was initially designed for the molecular repair of monogenic deficiency diseases, most of the current studies of gene therapy are targeting cancer.

Type
Special Section: Genetic Technology
Information
International Journal of Technology Assessment in Health Care , Volume 10 , Issue 4 , Fall 1994 , pp. 655 - 663
Copyright
Copyright © Cambridge University Press 1994

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References

REFERENCES

1.Avery, O. T., MacLeod, C. M., & McCarty, M.Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Journal of Experimental Medicine, 1944, 79, 137–58.CrossRefGoogle ScholarPubMed
2.Cohen, S. N., Chang, A. C. Y., Boyer, H. W., & Helling, R. B.Construction of biologically functional bacterial plasmids in vitro. Proceedings of the National Academy of Sciences of the United States of America, 1973, 70, 3240–44.CrossRefGoogle ScholarPubMed
3.Curiel, D. T., Wagner, E., Cotten, M. et al. , High efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Human Gene Therapy, 1992, 3, 147–54.CrossRefGoogle ScholarPubMed
4.Dodet, B.Commercial prospects for gene therapy — A company survey. Trends in Biotechnology, 1993, 11, 182–89.CrossRefGoogle ScholarPubMed
5.Jolly, D. J., Yee, J. K., & Friedmann, T.High efficiency gene transfer into cells. Methods in Enzymology, 1987, 149, 10–25.CrossRefGoogle ScholarPubMed
6.Kelly, T. J., & Smith, H. O. A restriction enzyme from Haemophilus influenzae. Journal of Molecular Biology, 1970, 51, 393–409.CrossRefGoogle Scholar
7.Meselson, M., & Yuan, R. DNA restriction enzyme from E. coli. Nature, 1968, 217, 1110–14.Google Scholar
8.Mitani, K., & Caskey, C. T.Delivering therapeutic genes — Matching approach and application. Trends in Biotechnology, 1993, 11, 162–66.CrossRefGoogle ScholarPubMed
9.Stewart, M. J., Plautz, G. E., DelBuono, L. et al. , Gene transfer in vivo with DNA- liposome complexes: Safety and acute toxicity in mice. Human Gene Therapy, 1992, 3, 267–75.CrossRefGoogle ScholarPubMed
10.Watson, J. D., & Crick, F. H. C.Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid. Nature, 1953, 171, 737–38.CrossRefGoogle ScholarPubMed
11.Wolff, J. A., Malone, R. W., Williams, P. et al. , Direct gene transfer into mouse muscle in vivo. Science, 1990, 247, 1465–68.CrossRefGoogle ScholarPubMed