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COST-EFFECTIVENESS ANALYSIS OF HERPES ZOSTER VACCINATION IN ITALIAN ELDERLY PERSONS

Published online by Cambridge University Press:  14 September 2016

Silvia Coretti ,
Paola Codella ,
Federica Romano Open the ORCID record for Federica Romano [Opens in a new window] ,
Matteo Ruggeri  and
Americo Cicchetti
Silvia Coretti
Affiliation:
Postgraduate School of Health Economics and Management, Università Cattolica del Sacro Cuore, Rome, [email protected]
Paola Codella
Affiliation:
Postgraduate School of Health Economics and Management, Università Cattolica del Sacro Cuore, Rome, Italy
Federica Romano
Affiliation:
Postgraduate School of Health Economics and Management, Università Cattolica del Sacro Cuore, Rome, Italy
Matteo Ruggeri
Affiliation:
Postgraduate School of Health Economics and Management, Università Cattolica del Sacro Cuore, Rome, Italy
Americo Cicchetti
Affiliation:
Director of Postgraduate School of Health Economics and Management, Università Cattolica del Sacro Cuore, Rome, Italy
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Abstract

Objectives: Herpes zoster (HZ) is characterized by a painful skin rash. Its main complication is postherpetic neuralgia (PHN), pain persisting or occurring after the rash onset. HZ treatment aims to reduce acute pain, impede the onset complications, and disease progression. The aim of this study was to assess the cost-effectiveness of HZ vaccination compared with no vaccination strategy, within the Italian context.

Methods: The natural history of HZ and PHN was mapped through a Markov model with lifetime horizon. A population of patients aged between 60 and 79 years was hypothesized. Third party payer (Italian National Health Service, I-NHS) and societal perspectives were adopted. Data were derived from literature.

Results and Conclusions: The incremental cost-effectiveness ratio of the vaccination equaled EUR 11,943 per quality-adjusted life-year (QALY) under the I-NHS perspective and EUR 11,248 per QALY under the societal perspective. Considering a cost-effectiveness threshold of EUR 30,000/QALY, the multi-way sensitivity analysis showed that vaccination is cost-effective regardless of the perspective adopted, in 99 percent of simulations.

Keywords

Economic evaluationDecision modelHerpes zosterPrevention
Type
Assessments
Information
International Journal of Technology Assessment in Health Care , Volume 32 , Issue 4 , 2016 , pp. 233 - 240
Copyright
Copyright © Cambridge University Press 2016 

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