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Cost-Benefit Analysis of Hepatitis-B Vaccination: A Computerized Decision Model for Spain

Published online by Cambridge University Press:  10 March 2009

Bengt Jönsson
Affiliation:
Linköping University
Bruno Horisberger
Affiliation:
Interdisciplinary Research Center for Public Health
Miguel Bruguera
Affiliation:
University of Barcelona
Lukas Matter
Affiliation:
University of Bern

Abstract

The availability and efficacy of recombinant deoxyribonucleic acid yeast-derived hepatitis-B vaccine, at a price much lower than the previously available plasma-derived hepatitis-B vaccines against hepatitis-B virus infections, motivate a new cost-benefit analysis of hepatitis-B vaccination. Spanish data were used to calculate direct and indirect costs of hepatitis-B infection and the costs and benefits of different vaccination strategies in defined risk groups of the Spanish population. A vaccination program will reduce direct expenditures for hepatitis B if the attack rate in the target population is higher than 4.9%. If indirect costs are included, the threshold for cost saving is reduced to 0.9%. The results are sensitive to the price of the vaccine, the duration of protection, assumptions about consequences for quality of life, and to indirect costs.

Type
General Essays
Copyright
Copyright © Cambridge University Press 1991

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