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Cost-Benefit Analysis of Hepatitis-B Vaccination: A Computerized Decision Model for Spain

Published online by Cambridge University Press:  10 March 2009

Bengt Jönsson ,
Bruno Horisberger ,
Miguel Bruguera  and
Lukas Matter
Bengt Jönsson
Affiliation:
Linköping University
Bruno Horisberger
Affiliation:
Interdisciplinary Research Center for Public Health
Miguel Bruguera
Affiliation:
University of Barcelona
Lukas Matter
Affiliation:
University of Bern
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Abstract

The availability and efficacy of recombinant deoxyribonucleic acid yeast-derived hepatitis-B vaccine, at a price much lower than the previously available plasma-derived hepatitis-B vaccines against hepatitis-B virus infections, motivate a new cost-benefit analysis of hepatitis-B vaccination. Spanish data were used to calculate direct and indirect costs of hepatitis-B infection and the costs and benefits of different vaccination strategies in defined risk groups of the Spanish population. A vaccination program will reduce direct expenditures for hepatitis B if the attack rate in the target population is higher than 4.9%. If indirect costs are included, the threshold for cost saving is reduced to 0.9%. The results are sensitive to the price of the vaccine, the duration of protection, assumptions about consequences for quality of life, and to indirect costs.

Type
General Essays
Information
International Journal of Technology Assessment in Health Care , Volume 7 , Issue 3 , Summer 1991 , pp. 379 - 402
Copyright
Copyright © Cambridge University Press 1991

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