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Novel Approaches to Controlled-Release Antigen Delivery

Published online by Cambridge University Press:  14 October 2009

Smadar Cohen ,
Maria J. Alonso  and
Robert Langer
Smadar Cohen
Affiliation:
Ben Gurion University of the Negev, Israel
Maria J. Alonso
Affiliation:
School of Pharmacy, Santiago de Compostela, Spain
Robert Langer
Affiliation:
Massachusetts Institute of Technology
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Abstract

Two strategies for vaccine-delivery systems, both relying on concepts of controlled-release technology, are described in this review. The first strategy involves using biodegradable polymer microspheres for parenteral and oral delivery of antigens. The other strategy combines two technologies, the encapsulation of antigen within liposomes and liposome encapsulation in hydrogels, to protect them from a rapid degradation in vivo. Both strategies have shown promise in terms of increasing the immunogenicity of poorly immunogenic peptides and protein vaccines. The microencapsulation process, antigen stability, mechanism of antigen release, and optimal release kinetics for vaccine delivery are reviewed, and the strengths and weaknesses of each approach are discussed.

Type
Special Section: Vaccines and Public Health: Assessing Technologies and Public Policies
Information
International Journal of Technology Assessment in Health Care , Volume 10 , Issue 1 , Winter 1994 , pp. 121 - 130
Copyright
Copyright © Cambridge University Press 1994

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