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A Multinational Economic Evaluation of rhDNase in the Treatment of Cystic Fibrosis

Published online by Cambridge University Press:  10 March 2009

Joseph Menzin ,
Gerry Oster ,
Linda Davies ,
Michael F. Drummond ,
Wolfgang Greiner ,
Carlo Lucioni ,
Jean-Louis Merot ,
Franco Rossi ,
J. Graf Schulenburg  and
Eric Souêtre
Joseph Menzin
Affiliation:
Policy Analysis Inc.
Gerry Oster
Affiliation:
Policy Analysis Inc.
Linda Davies
Affiliation:
University of York
Michael F. Drummond
Affiliation:
University of York
Wolfgang Greiner
Affiliation:
Universitat Hannover
Carlo Lucioni
Affiliation:
Istituto Economia Sanitaria
Jean-Louis Merot
Affiliation:
Benefit International
Franco Rossi
Affiliation:
Istituto Economia Sanitaria
J. Graf Schulenburg
Affiliation:
Universitat Hannover
Eric Souêtre
Affiliation:
Benefit International
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Abstract

Economic evaluations of Pharmaceuticals are increasingly being conducted in conjunction with randomized phase III clinical trials to meet the demand for pharmacoeconomic data when new products are launched. While the need for such data is often global, the trials in which relevant information may be collected are often conducted in only one or a limited number of countries. A critical issue is how data from pivotal clinical trials in one setting can serve as the basis for pharmacoeconomic evaluations in others. We address this issue and report on four economic evaluations that we undertook in conjunction with a recent U.S. phase III clinical trial of recombinant human deoxyribonuclease (rhDNase), which is used to improve pulmonary function in patients with cystic fibrosis (CF). The objective of these evaluations was to estimate the potential impact of rhDNase therapy in France, Germany, Italy, and the United Kingdom on the direct costs of medical care for the treatment of respiratory tract infections (RTIs) in patients with CF. Analyses of economic impact were undertaken

Type
General Essays
Information
International Journal of Technology Assessment in Health Care , Volume 12 , Issue 1 , Winter 1996 , pp. 52 - 61
Copyright
Copyright © Cambridge University Press 1996

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References

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