Cost-effectiveness of prophylaxis against on-demand treatment in boys with severe hemophilia A in Iran
Published online by Cambridge University Press: 22 October 2009
Abstract
Objective: The aim of this study was to assess the incremental cost-effectiveness of on-demand versus prophylactic hemophilia therapy in Iran from a third-party payers’ perspective.
Methods: A retrospective chart review of twenty-five type A hemophiliacs who were treated in three hemophilia treatment centers was conducted. The patients were boys 0–9 years old receiving one of two treatments: (i) prophylaxis with concentrate at clinic; (ii) concentrate at clinic as on-demand. Fourteen boys received on-demand infusions for bleeding events, and eleven boys received infusions prophylaxis. Data were extracted from documents in the hemophilia treatment centers during a period of approximately 6 months.
Results: The patients receiving prophylactic treatment had fewer bleeding events each month (mean, 0.26 versus 2.74) but used more concentrate (225.31 versus 87.20 units/kg per month). Average monthly cost per patient in the prophylaxis group was approximately 1.9 times higher than in the on-demand group. Compared with on-demand infusion, prophylaxis costs 3,201,656 Rials (€213.45) per bleeding event prevented.
Conclusion: Prophylactic care markedly reduces the number of bleeding episodes, but at considerable cost.
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- General Essays
- Information
- International Journal of Technology Assessment in Health Care , Volume 25 , Issue 4 , October 2009 , pp. 584 - 587
- Copyright
- Copyright © Cambridge University Press 2009
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