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The Clinical Use of Nuclear Magnetic Resonance Spectroscopy for Studying Human Muscle Metabolism

Published online by Cambridge University Press:  10 March 2009

E. B. Cady ,
R. D. Griffiths  and
R. H. T. Edwards
E. B. Cady
Affiliation:
Department of Medicine, Rayne InstituteUniversity College London School of Medicine
R. D. Griffiths
Affiliation:
Department of Medicine, Rayne InstituteUniversity College London School of Medicine
R. H. T. Edwards
Affiliation:
Department of Medicine, Rayne InstituteUniversity College London School of Medicine
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Extract

Nuclear magnetic resonance (NMR) imaging has recently become an accepted technique in the medical practitioner's armory (38). NMR spectroscopy (44) is a subtly different application of the same physical principles underlying NMR imaging, but the clinical potential for this modality is currently still under evaluation. The most important application of clinical NMR spectroscopy is for the nonin-vasive monitoring of changes in metabolite levels and intracellular pH of intact tissues during physiological stress or in response to pharmacological agents or disease. The 31phosphorus (31P) nucleus has been the most commonly investigated in muscle disease (39) but the applications of proton (1H), (4,5,8) and 13carbon (13C), (2,7) are currently being explored.

Type
An International View of Magnetic Resonance—Imaging and Spectroscopy
Information
International Journal of Technology Assessment in Health Care , Volume 1 , Issue 3 , July 1985 , pp. 631 - 645
Copyright
Copyright © Cambridge University Press 1985

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References

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