An organization needs to consider a number of preservation issues when building a special collection. The level of control one can exert over these issues will vary, but they can have a direct impact on the integrity of special collection materials. This presentation will briefly deal with concerns related to the types of materials being collected; room and location considerations; environmental conditions; and pest and mold issues. Many of these are interrelated, so this is not a truly systematic process. Rather, one will probably find it necessary to go back and forth among these topics.