This article describes the process and outcome of a systematic review that evaluated the effectiveness of workplace rehabilitation interventions for work-related low back pain (LBP). Between 1982 and 2005 CINAHL, MEDLINE, EMBASE and AMED databases were searched for studies of interventions that were provided at the workplace for workers with LBP. Using methodological quality appraisal 5 reviewers scrutinised the articles. A total of 1224 articles were reviewed and 15 articles, consisting of 10 studies, were deemed of sufficient quality to be included. The best evidence was clinical interventions with occupational interventions, as well as early return to work/modified work interventions, were effective in returning workers to work earlier, reducing pain and disability, and decreasing the rate of back injuries. Ergonomic interventions were also found to be effective workplace interventions.