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The role of autophagy during osteoclastogenesis under microgravity conditions

Published online by Cambridge University Press:  10 July 2018

Ioanna Markolefa  and
George I. Lambrou Open the ORCID record for George I. Lambrou [Opens in a new window]
Ioanna Markolefa
Affiliation:
Graduate Program ‘Metabolic Bones Diseases’, National and Kapodistrian University of Athens, Medical School, Mikras Asias 75, Goudi 11527, Athens, Greece
George I. Lambrou*
Affiliation:
Graduate Program ‘Metabolic Bones Diseases’, National and Kapodistrian University of Athens, Medical School, Mikras Asias 75, Goudi 11527, Athens, Greece First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Athens, Greece.
*
Author for correspondence: George I. Lambrou, E-mail: [email protected]
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Abstract

Space represents a rather hostile environment for the human body, with the bone loss being one of the most important consequences. Autophagy is a complex cellular process contributing to several cellular processes including recycling, nutrition, apoptosis and response to stressful environments. Recent reports have indicated that autophagy is a process that increases under microgravity conditions. In particular, this was shown to be true in skeletal cells such as the osteoclasts. Suppression of autophagy results in downregulation of osteoclastogenesis, making autophagy a quite tempting therapeutic target for preventing bone loss during space flights. The present work attempts to review the literature on the topic of autophagy role in osteoclastogenesis under microgravity conditions.

Keywords

Autophagymicrogravityosteoclastogenesis
Type
Review Article
Information
International Journal of Astrobiology , Volume 18 , Issue 4 , August 2019 , pp. 384 - 390
Copyright
Copyright © Cambridge University Press 2018 

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