The accomplishment of detailed geomorphological studies is a prerequisite for the location of regions in which the prevailing conditions in the past, or at present, may allow the development of possible life forms. The Atlantis basin, located in Sirenum Terrae, Southern hemisphere of Mars, is one of these astrobiologically interesting regions, where the existence of geological features such as ancient volcanic edifices, sedimentary deposits of an ancient lake and recent gullies seem to indicate the long-term presence of a thermal source and a water reservoir deep and stable enough to sustain biological processes. Here we describe the most relevant topographic and geomorphologic features in the region, highlighting the possibility for liquid water to have been present in the basin and outskirts in different moments of Mars' history. We also apply this analysis to an initial discussion of the influence of the hydrogeological evolution of the region in the putative development and/or survival of life forms in Atlantis basin.