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Engineering a lunar photolithoautotroph to thrive on the moon – life or simulacrum?

Published online by Cambridge University Press:  27 February 2018

A A Ellery
A A Ellery*
Affiliation:
Department of Mechanical & Aerospace Engineering, Carleton University, Ottawa, ON, K1S 5B6, Canada
*
Author for correspondence: A A Ellery, E-mail: [email protected]
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Abstract

Recent work in developing self-replicating machines has approached the problem as an engineering problem, using engineering materials and methods to implement an engineering analogue of a hitherto uniquely biological function. The question is – can anything be learned that might be relevant to an astrobiological context in which the problem is to determine the general form of biology independent of the Earth. Compared with other non-terrestrial biology disciplines, engineered life is more demanding. Engineering a self-replicating machine tackles real environments unlike artificial life which avoids the problem of physical instantiation altogether by examining software models. Engineering a self-replicating machine is also more demanding than synthetic biology as no library of functional components exists. Everything must be constructed de novo. Biological systems already have the capacity to self-replicate but no engineered machine has yet been constructed with the same ability – this is our primary goal. On the basis of the von Neumann analysis of self-replication, self-replication is a by-product of universal construction capability – a universal constructor is a machine that can construct anything (in a functional sense) given the appropriate instructions (DNA/RNA), energy (ATP) and materials (food). In the biological cell, the universal construction mechanism is the ribosome. The ribosome is a biological assembly line for constructing proteins while DNA constitutes a design specification. For a photoautotroph, the energy source is ambient and the food is inorganic. We submit that engineering a self-replicating machine opens up new areas of astrobiology to be explored in the limits of life.

Keywords

Biomimetic machinesengineered lifelunar environmentrobotic mechanismsself-replication
Type
Research Article
Information
International Journal of Astrobiology , Volume 17 , Special Issue 3: Robotic Astrobiology , July 2018 , pp. 258 - 280
Copyright
Copyright © Cambridge University Press 2018 

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References

Acevedo, F (2000) Use of reactors in biomining processes. Electronic Journal of Biotechnology 3(3).CrossRefGoogle Scholar
Adami, C (2006) Digital genetics: unravelling the genetic basis of evolution. Nature Genetics 7, 109–118.CrossRefGoogle ScholarPubMed
Akafa, H (1966) Abundances of selenium, tellurium and indium in meteorites. Journal of Geophysical Research 71(7), 1919–1923.Google Scholar
Amils, R, Fernandez-Remolar, D, Gomez, F, Aguilera, A, Gonzalez-Toril, E, Rodriguez, N (2003) ‘Importance of the iron cycle relevance to Mars exploration’. In Proceedings of the 3rd European Workshop on Exo-Astrobiology –Mars: The Search for Life (ESA SP-545), Madrid, Spain, 43–46.Google Scholar
Asai, D and Koonce, M (2001) Dynein heavy chain: structure, mechanics and evolution. Trends in Cell Biology 11(5), 196–202.CrossRefGoogle ScholarPubMed
Atsum, T (2001) Ultrasonic motor model for bacterial flagellar motors. Journal of Theoretical Biology 213, 31–51.CrossRefGoogle Scholar
Baas, P, Karabay, A and Qiang, L (2005) Microtubules cut and run. Trends in Cell Biology 15(10), 518–524.CrossRefGoogle ScholarPubMed
Balcazar, J, Gavalda, R and Siegelmann, H (1997) Computational power of neural networks: a characterization in terms of Kolmogorov complexity. IEEE Transaction of Information Theory 43(4), 1175–1183.CrossRefGoogle Scholar
Baum, E and Haussler, D (1989) What size net gives valid generalization? Journal of Neural Computation 1(1), 151–160.CrossRefGoogle Scholar
Bedau, M (1992) Philosophical aspects of artificial life. In Varela, F and Bourgine, P (eds). Towards A Practice of Autonomous Systems. Cambridge, MA: Bradford Books/MIT Press, pp. 494–503.Google Scholar
Bedau, M (1997) Emergent models of supple dynamics in life and mind. Brain & Cognition 34, 5–27.CrossRefGoogle ScholarPubMed
Bedau, M (1998) Four puzzles about life. Artificial Life 4, 125–140.CrossRefGoogle ScholarPubMed
Bedau, M (2003) Artificial life: organisation, adaptation and complexity from the bottom up. Trends in Cognitive Sciences 7(11), 505–512.CrossRefGoogle ScholarPubMed
Bedau, M, McCaskill, J, Packard, N, Rasmussen, S, Adami, C, Green, D, Ikegami, T, Kaneko, K and Ray, T (2000) Open problems in artificial life. Artificial Life 6, 363–376.CrossRefGoogle ScholarPubMed
Beggs, E, Costa, J and Tucker, J (2010) Physical oracles: the Turing machine and the Wheatstone bridge. Studia Logica 94, 1–22.Google Scholar
Ben-Jacobs, E (2009) Learning from bacteria about natural information processing. Annals of New York Academy of Sciences 1178, 78–90.CrossRefGoogle Scholar
Benner, S and Sismour, M (2005) Synthetic biology. Nature Reviews Genetics 6, 533–543.CrossRefGoogle ScholarPubMed
Berg, H (1974) Dynamic properties of bacterial flagellar motors. Nature 249, 77–79.CrossRefGoogle ScholarPubMed
Berg, H (1995) Torque generation by the flagellar rotary motor. Biophysical Journal 68, 163s–167s.Google ScholarPubMed
Berg, H (2003) Rotary motor of bacterial flagella. Annual Reviews Biochemistry 72, 19–54.CrossRefGoogle ScholarPubMed
Bersini, H (2010) Software replica of minimal living processes. Origins of Life & Evolution of Biospheres 40, 121–130.CrossRefGoogle ScholarPubMed
Bich, L and Damiano, L (2007) Theoretical and artificial construction of the living: redefining the approach from an autopoietic point of view. Origins of Life & Evolution of Biospheres 34, 459–464.CrossRefGoogle Scholar
Bird, L, Bonnefoy, V and Newman, D (2011) Bioenergetic challenges of microbial iron metabolism. Trends in Microbiology 19(7), 33–340.CrossRefGoogle Scholar
Blair, D (1991) Bacterial rotary motor. Nanotechnology 2, 123–133.CrossRefGoogle Scholar
Blair, D (1995) How bacteria sense and swim. Annual Reviews Microbiology 49, 489–522.CrossRefGoogle ScholarPubMed
Bland, P, Cintala, M, Horz, F and Cressey, G (2001) Survivability of meteorite projectriles – results from impact experiments. In 32nd Lunar & Planetary Science Conference, abstract no 1764.Google Scholar
Bland, P, Artemieva, N, Collins, G, Bottke, W, Bussey, D and Joy, K (2008) Asteroids on the Moon: projectile survival during low velocity impacts. In 39th Lunar & Planetary Science Conference, abstract no 2045.Google Scholar
Bloom, B (1995) Microbial minimalist. Nature 378, 236.CrossRefGoogle ScholarPubMed
Boden, M (2003) Alien life: how would we know? International Journal of Astrobiology 2(2), 121–129.CrossRefGoogle Scholar
Bourgine, P and Stewart, J (2004) Autopoiesis and cognition. Artificial Life 10, 327–345.CrossRefGoogle ScholarPubMed
Brack, A and Trouble, M (2010) Defining life: connecting robotics and chemistry. Origins of Life & Evolution of Biospheres 40, 131–136.CrossRefGoogle ScholarPubMed
Braitenburg, V (1984) Vehicles: Experiments in Synthetic Psychology. Cambridge, MA: MIT Press.Google Scholar
Brizard, A and van Esch, J (2009) Self-assembly approaches for the construction of cell architectures mimics. Soft Matter 5, 1320–1327.CrossRefGoogle Scholar
Bruylants, G, Bartik, K and Reisse, J (2010) Is it useful to have a clear-cut definition of life? On the use of fuzzy logic in prebiotic chemistry. Origins of Life & Evolution of Biospheres 40, 137–143.CrossRefGoogle ScholarPubMed
Burgess, S and Knight, P (2004) Is the dynein motor a winch? Current Opinion in Structural Biology 14, 138–146.CrossRefGoogle Scholar
Cabessa, J and Villa, A (2014) Interactive evolving recurrent neural networks are super-Turing. In Wermter, S, Weber, C, Duch, W, Honkela, T, Koprinkova-Hristova, P, Magg, S, Palm, G, Villa, A (eds). Lecture Notes in Computer Science, vol. 8681. Cham: Springer Publishers, pp. 57–64.Google Scholar
Cabessa, J and Siegelmann, H (2012) Computational power of interactive recurrent neural networks. Neural Computation 24(4), 996–1019.CrossRefGoogle ScholarPubMed
Cairns-Smith, A (1987) Genetic Takeover & the Mineral Origins of Life. Cambridge, UK: Cambridge University Press.Google Scholar
Cairns-Smith, A (1990) Seven Clues to the Origin of Life. Cambridge, UK: Cambridge University Press.Google Scholar
Calabretta, R (1998) Cellular automata in an artificial life perspective. In Bandini, S, Serra, R and Suggi Liverani, F (eds). Cellular Automata: Research Towards Industry. London: Springer-Verlag, pp. 243–246.CrossRefGoogle Scholar
Canfield, D, Rosing, M and Bjerrum, C (2006) Early anaerobic metabolisms. Philosophical Transactions of the Royal Society B 361, 1819–1836.CrossRefGoogle ScholarPubMed
Carter, F (1984) Molcular device computer: point of departure for large scale cellular automata. Physica 10D, 175–194.Google Scholar
Chaitin, G (1970) To a mathematical definition of ‘life’. ACM SICACT News 4, 12–18.CrossRefGoogle Scholar
Chirikjian, G, Zhou, Y and Suthakorn, J (2002) Self-replicating robots for lunar development. IEEE/ASME Transactions on Mechatronics 7(4), 462–472.CrossRefGoogle Scholar
Chodasewicz, K (2014) Evolution, reproduction and definition of life. Theory Biosciences 133, 39–45.CrossRefGoogle ScholarPubMed
Cockell, C (2011) Synthetic geomicrobiology: engineering microbe-mineral interactions for space exploration and settlement. International Journal of Astrobiology 10(4), 315–324.CrossRefGoogle Scholar
Cohen, P and Perrault, C (1979) Elements of a plan-based theory of speech acts. Cognitive Science 3(3), 177–212.Google Scholar
Collins, G (2012) Moonstruck magnetism. Science 335, 1176–1177.CrossRefGoogle ScholarPubMed
Cordova, N, Ermentrout, B and Oster, G (1992) Dynamics of single-motor molecules: the thermal ratchet model. Proceedings of the National Academy Sciences of the United States of America 89, 339–343.CrossRefGoogle ScholarPubMed
Cronin, L, et al. (2006) Imitation game – a computational chemical approach to recognising life. Nature Biotechnology 24(10), 1203–1206.CrossRefGoogle Scholar
Cross, R (2004) Kinetic mechanism of kinesin. Trends in Biochemical Sciences 29(6), 301–309.CrossRefGoogle ScholarPubMed
Cross, R and Carter, N (2000) Molecular motors. Current Biology 10(5), R177–R179.CrossRefGoogle ScholarPubMed
Crutchfield, J (1994) Calculi of emergence: computation, dynamics and induction. Physica D 75(1–3), 11–54.CrossRefGoogle Scholar
Csanyi, V and Kampus, G (1985) Autogenesis: the evolution of replicative systems. Journal of Theoretical Biology 114, 303–321.CrossRefGoogle ScholarPubMed
Cui, S and Friedman, A (1999) Analysis of a mathematical model of protocell. Journal of Mathematical Analysis & Applications 236, 171–206.CrossRefGoogle Scholar
Damiano, L and Luigi Luisi, P (2010) Towards an autopoietic redefinition of life. Origins of Life & Evolution of Biospheres 40, 145–149.CrossRefGoogle ScholarPubMed
Deamer, D and Pashley, R (1989) Amphiphilic components of the Murchison carbonaceous chondrite: surface properties and membrane formation. Origins of Life & Evolution of the Biosphere 19, 21–38.CrossRefGoogle ScholarPubMed
Deamer, D, Dworkin, J, Sandford, S, Bernstein, M and Allamandola, L (2002) First cell membranes. Astrobiology 2(2), 371–381.CrossRefGoogle ScholarPubMed
Deming, T (1997) Polypeptide materials: new synthetic methods and applications. Advanced Materials 9(4), 299–311.CrossRefGoogle Scholar
Deplazes, A and Huppenbauer, M (2009) Synthetic organisms and living machines. Systems & Synthetic Biology 3, 55–63.CrossRefGoogle ScholarPubMed
DeRosier, D (1998) Turn of the screw: the bacterial flagellar motor. Cell 93, 17–20.CrossRefGoogle ScholarPubMed
Deutsch, D (1985) Quantum theory, the Church-Turing principle and the universal quantum computer. Proceedings of The Royal Society A 400, 97–117.Google Scholar
Dohner, K, Nagel, C-H and Sodeik, B (2005) Viral stop-and-go along microtubules: taking a ride with dynein and kinesin. Trends in Microbiology 13(7), 320–327.CrossRefGoogle Scholar
Dutcher, S (1995) Flagellar assembly in two hundred and fifty easy-to-follow steps. Trends in Genetics 11(10), 398–404.CrossRefGoogle ScholarPubMed
Edwards, M (1998) From a soup or a seed? Pyritic metabolic complexes in the origin of life. Trends in Ecology & Evolution 13(5), 178–181.CrossRefGoogle ScholarPubMed
Egelman, E (2003) Actin's prokaryotic homologs. Current Opinion in Structural Biology 13, 244–248.CrossRefGoogle ScholarPubMed
Eiben, A (2014) Grand challenges for evolutionary robotics. Frontiers in Robotics & AI 1(Jun), 1–8.CrossRefGoogle Scholar
Elani, Y, Law, R and Ces, O (2014) Vesicle-based artificial cells as chemical microreactors with spatially segregated reaction pathways. Nature Communications 5, 5305.CrossRefGoogle ScholarPubMed
Ellery, A (2015) Ultimate smart system – steps towards a self-replicating machine. In Proceedings of the 5th International Conference on Smart Materials & Structures, pp. 225–234.Google Scholar
Ellery, A (2016a) Are self-replicating machines feasible? AIAA J Spacecraft & Rockets 53(2), 317–327.CrossRefGoogle Scholar
Ellery, A (2016b) How to build a self-replicating machine on the Moon. In Proceedings of the ASCE Earth & Space Conference, Orlando, pp. 713–724.CrossRefGoogle Scholar
Ellery, A (2016c) Solar power satellites for clean energy enabled through disruptive technologies. In Proceedings of the 23rd World Energy Congress (Award Winning Papers), Istanbul, Turkey, pp. 133–147.Google Scholar
Ellery, A (2016d) John von Neumann's self-replicating machine – critical components required. In Proceedings of the IEEE International Conference on Systems Man & Cybernetics, Budapest, Hungary, pp. 314–319.CrossRefGoogle Scholar
Ellery, A et al. (2004) Bionics & Space Systems Design 1 – Overview of Biomimetics Technology. ESA-ESTEC Technical Note 1, ESA Contract no 18203/04/NL/PA.Google Scholar
Endy, D (2005) Foundations for engineering biology. Nature 438, 449–453.CrossRefGoogle ScholarPubMed
Engelborghs, Y (1994) Microtubules: dissipative structures formed by self-assembly. Biosensors & Bioelectronics 9, 685–689.CrossRefGoogle Scholar
Ermentrout, B and Edelatein-Keshet, L (1993) Cellular automata approaches to biological modelling. Journal of Theoretical Biology 160, 97–133.CrossRefGoogle Scholar
Fegley, B and Swindle, T (1993) Lunar volatiles: implications for lunar resource utilization. In Lewis, J, Matthews, M and Gurrieri, M (eds). Resources of Near Earth Space. Tucson, AZ: University of Arizona Press, pp. 367–426.Google Scholar
Ferris, H and Minamino, T (2006) Flipping the switch: bringing order to flagellar assembly. Trends in Microbiology 14(12), 519–526.CrossRefGoogle ScholarPubMed
Ferris, J (2005) Mineral catalysis and prebiotic synthesis: montmorillonite-catalysed formation of RNA. Elements 1, 145–149.CrossRefGoogle Scholar
Ferris, J, Hill, A, Liu, R and Orgel, L (1996) Synthesis of long prebiotic oligomers on mineral surfaces. Nature 381, 59–61.CrossRefGoogle ScholarPubMed
Ferris, J, Joshi, P, Wang, K-J, Miyakawa, S and Huang, W (2004) Catalysis in prebiotic chemistry: application to the synthesis of RNA oligomers. Advances in Space Research 33, 100–105.CrossRefGoogle Scholar
Fleischaker, G (1989) Autopoiesis: the status of its system logic. BioSystems 22, 37–49.CrossRefGoogle Scholar
Fontana, W and Buss, L (1994) Arrival of the fittest: toward a theory of biological organisation. Bull Mathematical Biology 56(1), 1–64.Google Scholar
Forterre, P (2010) Defining life: the virus viewpoint. Origins of Life & Evolution of Biospheres 40, 151–160.CrossRefGoogle ScholarPubMed
Freitas, R & Gilbreath, W (1980) Advanced Automation for Space Missions. In Proceedings of the 1980 NASA/ASEE Summer Study, NASA CP-2255, Santa Clara, CA.Google Scholar
Freitas, R & Merkle, R (2004) Kinematic Self-Replicating Machines. Austin TX: Landes Bioscience.Google Scholar
Frixione, E (2000) Recurring views on the structure and function of the cytoskeleton: a 300 year epic. Cell Motility & the Cytoskeleton 46, 73–94.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Froese, T and Stewart, J (2010) Life after Ashby: ultrastability and the autopoietic foundations of biological autonomy. Cybernetics & Human Knowing 17(4), 7–50.Google Scholar
Gabora, L (2006) Self-other organisation: why early life did not evolve through natural selection. Journal of Theoretical Biology 241, 443–450.CrossRefGoogle Scholar
Gerdes, K, Meller-Jensen, J, Ebersbach, G, Kruse, T and Nordstrom, K (2004) Bacterial mitotic machineries. Cell 116, 359–366.CrossRefGoogle ScholarPubMed
Gibbs, W (2004) Synthetic life. Scientific American 290(5), 74–81.CrossRefGoogle ScholarPubMed
Goldin, D and Wegner, P (2005) Church-Turing thesis: breaking the myth. In Cooper, S, Lowe, B and Torenvliet, L (eds) Lecture Notes in Computer Science vol. 3526. Berlin/Heidelberg, Germany: Springer-Verlag, pp. 152–168.Google Scholar
Goldstein, L (2001) Molecular motors: from one motor many tails to one motor many tails. Trends in Cell Biology 11(12), 477–482.CrossRefGoogle ScholarPubMed
Goudreau, M, Giles, L, Chakradhar, S and Chen, D (1994) First order vs second order single layer recurrent neural networks. IEEE Transactions on Neural Networks 5(3), 511–513.CrossRefGoogle Scholar
Han, J-W and Meyyappan, M (2014) Device made of nothing: the vacuum transistor could one day replace silicon. IEEE Spectrum (Jul), 31–35.Google Scholar
Hanczyc, M (2011) Metabolism and motility in prebiotic structures. Philosophical Transactions of the Royal Society B 366, 2885–2893.CrossRefGoogle ScholarPubMed
Hess, H and Vogel, V (2001) Molecular shuttles based on motor proteins: active transport in synthetic environments. Reviews in Molecular Biotechnology 82, 67–85.CrossRefGoogle ScholarPubMed
Hordijk, W (2013) Autocatalytic sets: from the origin of life to the economy. Bioscience 63(11), 877–881.Google Scholar
Howard, J, Hudspeth, A and Vale, R (1989) Movement of microtubules by single kinesin molecules. Nature 342, 154–158.CrossRefGoogle ScholarPubMed
Huitorel, P (1988) From cilia and flagella to intracellular motility and back again: a review of a few aspects of microtubule-based motility. Biology of the Cell 63, 249–258.CrossRefGoogle ScholarPubMed
Hutton, T (2002) Evolvable self-replicating molecules in an artificial chemistry. Artificial Life 8(4), 341–356.CrossRefGoogle Scholar
Hutton, T (2009) Codd's self-replicating computer. Artificial Life 16(2), 99–117.CrossRefGoogle Scholar
Huxley, A (2000) Mechanics and models of the myosin motor. Philosophical Transactions of the Royal Society B 355, 433–440.CrossRefGoogle ScholarPubMed
Huxley, H (1996) Personal view of muscle and motility mechanisms. Annual Review of Physiology 58, 1–19.CrossRefGoogle ScholarPubMed
Itoh, H, Takahashi, A, Adachi, K, Noji, H, Yasuda, R, Yoshida, M and Kinosita, K (2004) Mechanically driven ATP synthesis by F1-ATPase. Nature 427, 465–468.CrossRefGoogle ScholarPubMed
Jacobson, H (1959) Informational content of mechanisms and circuits. Information & Control 2, 285–296.CrossRefGoogle Scholar
Jones, R, Haufe, P, Sells, E, Iravani, P, Olliver, V, Palmer, C and Bowyer, A (2011) Reprap – the replicating rapid prototyper. Robotica 29(Jan), 177–191.CrossRefGoogle Scholar
Jorgensen, S and Fath, B (2004) Application of thermodynamic principles in ecology. Ecological Complexity 1, 267–280.CrossRefGoogle Scholar
Karcher, R, Deacon, S and Gelfand, V (2002) Motor-cargo interactions: the key to transport specificity. Trends in Cell Biology 12(1), 21–27.CrossRefGoogle ScholarPubMed
Karplus, M and Gao, Y (2004) Biomolecular motors: the F1-ATPase paradigm. Current Opinion in Structural Biology 14, 250–259.CrossRefGoogle ScholarPubMed
Kephart, J and Chess, D (2003) Vision of autonomic computing. IEEE Computer 36(1), 41–58.CrossRefGoogle Scholar
Kinosita, K, Yasuda, R, Noji, H, Ishiwata, S and Yoshida, M (1998) F1-ATPase: a rotary motor made of a single molecule. Cell 93, 21–24.CrossRefGoogle ScholarPubMed
Klavins, E (2004) Universal self-replication using graph grammars. In Proceedings of the International Conference on MEMS, NANO and Smart Systems, Banff, Canada, paper no. 1508947.Google Scholar
Kolesar, E and Dyson, C (1995) Object imaging with a piezoelectric robotic tactile sensor. IEEE Journal of Microelectromechanical Systems 4(2), 87–96.CrossRefGoogle Scholar
Koonce, M and Samso, M (2004) Of rings and levers: the dynein motor comes of age. Trends in Cell Biology 14(11), 612–619.CrossRefGoogle ScholarPubMed
Korzeniewski, B (2001) Cybernetic formulation of the definition of life. Journal of Theoretical Biology 209, 275–286.CrossRefGoogle ScholarPubMed
Koshland, D (2002) Seven pillars of life. Science 295, 2215–2216.CrossRefGoogle ScholarPubMed
Kull, J, Sablin, E, Lau, R, Fletterick, R and Vale, R (1996) Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature 380, 550–555.CrossRefGoogle ScholarPubMed
Kwok, R (2010) Five hard truths for synthetic biology. Nature 463, 288–290.CrossRefGoogle ScholarPubMed
LaBar, T, Adami, C and Hintze, A (2015) Does self-replication imply evolvability? In Proceedings of the 13th European Conference on Artificial Life, pp. 596–602.Google Scholar
Lahoz-Beltra, R (1997) Molecular automata assembly: principles and simulation of bacterial membrane construction. BioSystems 44, 209–229.CrossRefGoogle ScholarPubMed
Laing, R (1975) Some alternative reproductive strategies in artificial molecular machines. Journal of Theoretical Biology 54, 63–84.CrossRefGoogle ScholarPubMed
Laing, R (1979) Machines as organisms: an exploration of the relevance of recent results. BioSystems 11, 201–215.CrossRefGoogle ScholarPubMed
Langton, C (1984) Self-reproduction in cellular automata. Physica D 10, 135–144.CrossRefGoogle Scholar
Larson, S & Ellery, A (2015) Trainable analogue neural network with application to lunar in-situ resource utilisation. In Proceedings of the International Astronautics Federation Congress, Jerusalem, IAC-15-D3.3.6.Google Scholar
Lazcano, A (2010) Which way to life? Origins of Life & Evolution of Biospheres 40, 161–167.CrossRefGoogle ScholarPubMed
Lee, E (2005) Building unreliable systems out of reliable components: the real time story. Electrical Engineering & Computer Sciences University of California Berkeley Technical Report No. UCB/EECS-2005–5.Google Scholar
Letelier, J, Marin, G and Mpoodoziz, J (2003) Autopoietic and (M, R) systems. Journal of Theoretical Biology 222, 261–272.CrossRefGoogle ScholarPubMed
Luigi Luisi, P (2003) Autopoiesis: a review and a reappraisal. Naturwissenschaften 90, 49–59.CrossRefGoogle Scholar
Luigi Luisi, P and Varela, F (1989) Self-replicating micelles – a chemical version of a minimal autopoietic system. Origins of Life & Evolution of the Biosphere 19, 633–643.CrossRefGoogle Scholar
Luisi, P (1998) About various definitions of life. Origins of Life & Evolution of Biospheres 28, 613–622.CrossRefGoogle ScholarPubMed
Machery, E (2012) Why I stopped worrying about the definition of life … and why you should as well. Synthese 185(1), 145–164.CrossRefGoogle Scholar
MacLennan, B (2004) Natural computation and non-Turing models of computation. Theoretical Computer Science 317, 115–145.CrossRefGoogle Scholar
MacNab, R (2003) How bacteria assemble flagella. Annual Reviews of Microbiology 57, 77–100.CrossRefGoogle ScholarPubMed
Mandelkow, E and Mandelkow, E-M (2002) Kinesin motors and disease. Trends in Cell Biology 12(12), 585–590.CrossRefGoogle ScholarPubMed
Margenstein, M (2000) Frontier between decidability and undecidability: a survey. Theoretical Computer Science 231, 217–251.CrossRefGoogle Scholar
Martin, W and Russell, M (2003) On the origins of cells: a hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells. Philosophical Transactions of the Royal Society B 358, 59–83.CrossRefGoogle Scholar
Maturana, H (1975) Organisation of the living: a theory of the living organisation. International Journal of Man-Machine Studies 7, 313–332.CrossRefGoogle Scholar
McDaniel, R and Weiss, R (2005) Advances in synthetic biology: on the path from prototypes to applications. Current Opinion in Biotechnology 16, 476–485.CrossRefGoogle ScholarPubMed
McDermott, K, Price, M, Cole, M and Burchell, M (2016) Survivability of copper projectuiles during hypervelocity impacts in porous ice: a laboratory investigation of the survivability of projectiles impacting comets or other bodies. Icarus 268, 102–117.CrossRefGoogle Scholar
McMullin, B (2004) Thirty years of computational autopoiesus: a review. Artificial Life 10, 277–295.CrossRefGoogle ScholarPubMed
McMullin, B & Varela, F (1997) Rediscovering computational autopoiesis. In Proceedings of the European Conference on Artificial Life, paper no. 97-02-012.Google Scholar
Melosh, H, Freed, A, Johnson, B, Blair, D, Andrews-Hanna, J, Neumann, G, Phillips, R, Smith, D, Solomon, S, Wieczorek, M and Zuber, M (2013) Origin of lunar mascon basins. Science 340, 1552–1555.CrossRefGoogle ScholarPubMed
Menezes, A, Montague, M, Cumbers, J, Hogan, J and Arkin, A (2015) Grand challenges in space synthetic biology. Journal of the Royal Society Interface 12, 20150803.CrossRefGoogle ScholarPubMed
Miki, H, Okada, Y and Hirokawa, N (2005) Analysis of the kinesin superfamily: insights into structure and function. Trends in Cell Biology 15(10), 467–476.CrossRefGoogle ScholarPubMed
Mitchell, M (1998) Computation in cellular automata: a selected review. In Gramss, T, Bornholdt, S, Gross, M and Mitchell, M (eds). Nonstandard Computation. Weinheim, Germany: VCH Publishers, pp. 95–140.CrossRefGoogle Scholar
Montesi, L (2013) Solving the mascon mystery. Science 340, 1535–1536.CrossRefGoogle ScholarPubMed
Moore, E (1956) Artificial Living Plants. Scientific American, 195(4), 118–126.Google Scholar
Moreno Bergareche, A and Ruiz-Mirazo, K (1999) Metabolism and the problem of its universalisation. BioSystems 49, 45–61.CrossRefGoogle Scholar
Morowitz, H, Heinz, B and Deamer, D (1988) Chemical logic of a minimum protocell. Origins of Life & Evolution of the Biosphere 18, 281–287.CrossRefGoogle ScholarPubMed
Moses, M, Ma, H, Wolfe, K and Chirikjian, G (2014) An architecture for universal construction via modular robotic components. Robotics & Autonomous Systems 62(7), 945–965.CrossRefGoogle Scholar
Mozafari, R (2005) Liposomes: an overview of manufacturing techniques. Cellular & Molecular Biology Letters 10, 711–719.Google ScholarPubMed
Muller, A (2003) Finding extraterrestrial organisms living on thermosynthesis. Astrobiology 3(3), 555–564.CrossRefGoogle ScholarPubMed
Narisawa, M (2010) Silicone resin applications for precursors and composites. Materials 3, 3518–3586.CrossRefGoogle Scholar
Oakley, B (2000) Abundance of tubulins. Trends in Cell Biology 10(Dec), 537–542.CrossRefGoogle ScholarPubMed
Ochman, H, Lawrence, J and Groisman, E (2000) Lateral gene transfer and the nature of bacterial innovation. Nature 405, 299–304.CrossRefGoogle ScholarPubMed
Oro, J, Kimball, A, Fritz, R and Master, F (1959) Amino acid synthesis from formaldehyde and hydroxylamine. Archives of Biochemistry & Biophysics 86, 115–130.CrossRefGoogle Scholar
Oster, G and Wang, H (2003) Rotary protein motors. Trends in Cell Biology 13(3), 114–121.CrossRefGoogle ScholarPubMed
Paun, C (2000) Computing with membranes. J Computer & System Sciences 61, 108–143.CrossRefGoogle Scholar
Pesavento, U (1995) Implementation of von Neumann's self-reproducing machine. Artificial Life 2(4), 337–354.CrossRefGoogle ScholarPubMed
Pinto, J, Gladstone, G and Yung, Y (1980) Photochemical production of formaldehyde in Earth's primitive atmosphere. Science 210, 183–185.CrossRefGoogle ScholarPubMed
Pohorille, A and Deamer, D (2002) Artificial cells: prospects for biotechnology. Trends in Biotechnology 20(3), 123–128.CrossRefGoogle ScholarPubMed
Pross, A (2005a) Stability in chemistry and biology: life as a kinetic state of matter. Pure Applied Chemistry 77(11), 1905–1921.CrossRefGoogle Scholar
Pross, A (2005b) On the emergence of biological complexity: life as a kinetic state of matter. Origins of Life & Evolution of Biospheres 35, 151–166.CrossRefGoogle ScholarPubMed
Pross, A (2008) How can a chemical system act purposefully? Bridging between life and non-life. Journal of Physical Organic Chemistry 21, 724–730.CrossRefGoogle Scholar
Pross, A and Pascal, R (2013) Origin of life: what we know, what we can know and what we will never know. Open Biology 3, 120190.CrossRefGoogle ScholarPubMed
Rasmussen, S, Chen, L, Nilsson, M and Abe, S (2003) Bridging nonliving and living matter. Artificial Life 9(3), 269–316.CrossRefGoogle ScholarPubMed
Rasmussen, S, Chen, L, Deamer, D, Krakauer, D, Packard, N, Stadler, P and Bedau, M (2004) Transitions from nonliving to living matter. Science 303, 963–965.CrossRefGoogle ScholarPubMed
Rawlings, A, Bramble, J and Staniland, S (2012) Innovation through imitation: biomimetic, bioninspired and biokleptic research. Soft Matter 8, 6675–6679.CrossRefGoogle Scholar
Reggia, J, Armentrout, S, Chou, H-H and Peg, Y (1993) Simple systems exhibiting self-directed replication. Science 259, 1282–1286.CrossRefGoogle ScholarPubMed
Reimold, W, Koeberl, C, Gibson, R and Dressler, B (2005) Economic mineral deposits in impact structures: a review. In Koebert, C and Henkel, H (eds). Impact Tectonics. Impact Studies, vol. 6. Heidelberg: Springer, pp. 479–548.CrossRefGoogle Scholar
Ringwood, A & Seifert, S (1986) Nickel-cobalt abundance systematics and their bearing on lunar origin. In Proceedings of the Origins of the Moon Conference, pp. 249–278.Google Scholar
Ruiz-Mirazo, K, Pereto, J and Moreno, A (2004) Universal definition of life: autonomy and open-ended evolution. Origins of Life & Evolution of Biospheres 34, 232–346.CrossRefGoogle ScholarPubMed
Saunders, P and Ho, M (1976) On the increase in complexity in evolution. Journal of Theoretical Biology 63, 375–394.CrossRefGoogle ScholarPubMed
Schark, M (2012) Synthetic biology and the distinction between organisms and machines. Environmental Values 21, 19–41.CrossRefGoogle Scholar
Schmidhuber, J (2007) Godel machines: fully self-referential optimal universal self-improvers. In Goertzel, B and Pennachin, C (eds). Artificial General Intelligence. Berlin, Heidelberg: Springer, pp. 199–226.CrossRefGoogle Scholar
Schneider, E and Kay, J (1994) Life as a manifestation of the second law of thermodynamics. Mathematical & Computer Modelling 19(6–8), 25–48.CrossRefGoogle Scholar
Schuindewolf, U (1980) Selenium and tellurium content of stony meteorites by neutron activation. Geochimica et Cosmochimica 19, 134–136.CrossRefGoogle Scholar
Schultze-Makuch, D and Irwin, L (2004) Life in the Universe: expectations and constraints. In Springer Advances in Astrobiology & Biogeophysics. Berlin, Germany: Springer Publishers.Google Scholar
Schulze-Makuch, D and Irwin, L (2008) Life in the Universe: Expectations and Constraints. Berlin, Germany: Springer Publishers.CrossRefGoogle Scholar
Schuster, S and Khan, S (1994) Bacterial flagellar motor. Annual Reviews Biophysics & Biomolecular Structure 23, 509–539.CrossRefGoogle ScholarPubMed
Schwartz, A (1996) Did minerals perform prebiotic combinatorial chemistry? Chemistry & Biology 3, 515–518.CrossRefGoogle ScholarPubMed
Schwede, J, Bargstin, I, Riley, D, Hardin, B, Rosenthal, S, Sun, Y, Schmitt, F, Pianetta, P, Howe, R, Shen, Z-X and Melosh, N (2010) Photon-enhanced thermionic emission for solar concentrator systems. Nature Materials 9, 762–767.CrossRefGoogle ScholarPubMed
Schwegler, H and Tarumi, K (1986) Protocell: a mathematical model of self-maintenance. BioSystems 19, 307–315.CrossRefGoogle ScholarPubMed
Senior, A and Wise, J (1983) Proton-ATPase of bacteria and mitochondria. Journal of Membrane Biology 73, 105–124.CrossRefGoogle ScholarPubMed
Siegelmann, H. (1995) Computation beyond the Turing limit. Science 268, 545–458.CrossRefGoogle ScholarPubMed
Siegelmann, H and Margenstern, M (1999) Nine switch-affine neurons suffice for Turing universality. Neural Networks 12, 593–600.CrossRefGoogle ScholarPubMed
Siegelmann, H and Sontag, E. (1995) On the computational power of neural nets. Journal of Computer & System Sciences 50, 132–150.CrossRefGoogle Scholar
Sipper, M, Sanchez, E, Mange, D, Tomassini, M, Perez-Uribe, A and Stauffer, A (1997) ‘Phylogenetic, ontogenetic, and epigenetic view of bio-inspired hardware systems. IEEE Transactions on Evolutionary Computations 1(1), 83–97.CrossRefGoogle Scholar
Sismour, M and Benner, S (2005) Synthetic biology. Expert Opinion on Biological Therapy 5(11), 1409–1424.CrossRefGoogle ScholarPubMed
Skulachev, V (2001) Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends in Biochemical Sciences 26(1), 23–29.CrossRefGoogle ScholarPubMed
Soong, R, Bachand, G, Neves, H, Olkhovets, A, Craighead, H and Montemagno, C (2000) Powering a inorganic nanodevice with a biomolecular motor. Science 290, 1555–1558.CrossRefGoogle ScholarPubMed
Stahlberg, A, Schuster, S, Bauer, M, Baueurlein, E, Zhao, R, Reese, T and Khan, S (1995) Conserved machinery of the bacterial flagellar motor. Biophysical Journal 58(Apr), 168s–172sGoogle Scholar
Stepney, S (2012) Programming unconventional computers: dynamics, development, self-reference. Entropy 14, 1939–1952.CrossRefGoogle Scholar
Sun, G-Z, Chen, H-H, Lee, Y-C and Giles, C (1991) Turing equivalence of neural networks with second order connection weights. In Proceedings of International Joint Conference on Neural Networks, vol. 2, pp. 357–362.CrossRefGoogle Scholar
Suthakorn, J and Chirikjian, G (2006) Toward self-replication of robot control circuitry by self-inspection In Ang, M and Khatib, O (eds). Environmental Robotics IX. Berlin: Springer-Verlag, pp. 303–309.Google Scholar
Svoboda, K and Block, S (1994) Force and velocity measured for single kinesin molecules. Cell 77, 773–784.CrossRefGoogle ScholarPubMed
Szostak, J (2012) Attempts to define life do not help to understand the origin of life. Journal of Biomolecular Structure & Dynamics 29(4), 599–600.CrossRefGoogle Scholar
Szostak, J, Bartel, D and Luigi Luisi, P (2001) Synthesising life. Nature 409, 387–390.CrossRefGoogle ScholarPubMed
Szostak, N, Wasik, S, Blazewicz, J (2016) Hypercycle. PLoS Computational Biology 12(4), e1004853.CrossRefGoogle ScholarPubMed
Tabony, J, Pochon, N and Papaseit, C (2001) Microtubule self-organisation depends upon gravity. Advances in Space Research 28(4), 529–535.CrossRefGoogle ScholarPubMed
Taylor, E (2001) Cell as molecular machine. Molecular Biology of the Cell 12(2), 251–254.CrossRefGoogle ScholarPubMed
Teuscher, C (2014) Unconventional computing catechism. Frontiers in Robotics & AI 1(Nov), 10.CrossRefGoogle Scholar
Teuscher, C and Sipper, M (2002) Hypercomputation’ - hype or computation? Communications of the ACM 45(8), 23–24.CrossRefGoogle Scholar
Thomas, N, Bardy, S and Jarrell, K (2001) Archaeal flagellum: a different kind of prokaryotic motility structure. FEMS Microbiology Review 25, 147–174.CrossRefGoogle ScholarPubMed
Tucker, J and Zilinskas, R (2006) Promise and perils of synthetic biology. New Atlantis (Spring), 25–45.Google ScholarPubMed
Turing, A (1937) On computable numbers with an application to the entschedungsproblem. Proceedings of London Mathematical Society, Series 2, 42, 230–265.CrossRefGoogle Scholar
Tuszynski, J, Trpisova, B, Sept, D and Sataric, M (1997) Enigma of microtubules and their self-organising behaviour in the cytoskeleton. BioSystems 42, 153–175.CrossRefGoogle Scholar
Tyreman, M and Molloy, J (2003) Molecular motors: nature's nanomachines. IEE Proceedings, Nanobiotecnology 150(3), 95–102.CrossRefGoogle ScholarPubMed
Tyson, J and Mackey, M (2001) Molecular, metabolic and genetic control: an introduction. Chaos 11(1), 81–83.CrossRefGoogle ScholarPubMed
Ulanowicz, R and Hannon, B (1987) Life and the production of entropy. Proceedings of the Royal Society B 232, 181–192.Google Scholar
Umerez, J (2010) Artificial life: prospects of a synthetic biology. In Angelo L and Queiroz J (eds). Advances in Modelling Adaptive & Cognitive Systems. Brazil: UEFS Open Publishing, pp. 4–16.Google Scholar
Vale, R (1999) Millenial musings on molecular motors. Trends in Biochemical Science 24(12), M38–M41.Google Scholar
Vale, R (2003) Molecular motor toolbox for intracellular transport. Cell 112, 467–480.CrossRefGoogle ScholarPubMed
Vale, R and Milligan, R (2000) The way things move: looking under the hood of molecular motor proteins. Science 288, 88–95.CrossRefGoogle ScholarPubMed
Vallee, R and Stehman, S (2005) How dynein helps the cell find its centre: a servomechanical model. Trends in Cell Biology 15(6), 288–294.CrossRefGoogle ScholarPubMed
van den Ent, F, Amos, L and Lowe, J (2001a) Prokaryotic origin of the actin cytoskeleton. Nature 413, 39–44.CrossRefGoogle ScholarPubMed
van den Ent, F, Amos, L and Lowe, J (2001b) Bacterial ancestry of actin and tubulin. Current Opinion in Microbiology 4, 634–638.CrossRefGoogle ScholarPubMed
Varatharajoo, R (2004) Combined energy and attitude control system for small satellites. Acta Astronautica 54, 701–712.CrossRefGoogle Scholar
Varela, F, Maturana, H and Uribe, R (1974) Autopoiesis: the organisation of living systems, its characterisation and a model. BioSystems 5, 187–196.CrossRefGoogle ScholarPubMed
von Neumann, J & Burks, A (eds) (1966) Theory of Self-Reproducing Automata. IL: University of Illinois Press.Google Scholar
Wachtershausen, G (2006) From volcanic origins of chemoautotrophic life to bacteria, archaea and eukarya. Philosophical Transactions of the Royal Society B 361, 1787–1808.CrossRefGoogle Scholar
Wachtershauser, G (1990) Case for the chemoautotrophic origin of life in an iron-sulphur world. Origins of Life & Evolution of Biospheres 20, 173–176.CrossRefGoogle Scholar
Wachtershauser, G (1992) Groundworks for evolutionary biochemistry: the iron-sulphur world. Progress in Biophysics & Molecular Biology 58, 85–201.CrossRefGoogle ScholarPubMed
Wang, H and Oster, G (1998) Energy transduction in the F1 motor of ATP synthase. Nature 396, 279–282.CrossRefGoogle ScholarPubMed
Way, J, Silver, P and Howard, R (2011) Sun-driven microbial synthesis of chemicals in space. International Journal of Astrobiology 10(4), 359–364.CrossRefGoogle Scholar
Weber, J (2007) ATP synthase – the structure of the stator stalk. Trends in Biochemical Sciences 32(2), 53–56.CrossRefGoogle ScholarPubMed
Weber, B (2010) What is life? Defining life in the context of emergent complexity. Origins of Life & Evolution of Biospheres 40, 221–229.CrossRefGoogle ScholarPubMed
Weber, K, Achenbach, L and Coates, J (2006) Microbes pumping iron: anaerobic microbial iron oxidation and reduction. Nature Reviews Microbiology 4, 752–764.CrossRefGoogle Scholar
Wemmer, K and Marshall, W (2004) Flagellar mobility: all pull together. General Biology 14, R992–R993.Google Scholar
Widdel, F, Schnell, S, Easing, S, Ehrenreich, A, Assmus, B and Schink, B (1983) Ferrous iron oxidation by anoxygenic phototrophic bacteria. Nature 362, 834–838.CrossRefGoogle Scholar
Wieczorek, M and Phillips, R (1999) Lunar multiring basins and the cratering process. Icarus 139, 246–259.CrossRefGoogle Scholar
Wieczorek, M, Weiss, B and Steart, S (2012) Impactor origin for lunar magnetic anomalies. Science 335, 1212–1215.CrossRefGoogle ScholarPubMed
Wierdermann, J and van Leeuwen, J (2002) Emergent computational potential of evolving artificial living systems. Journal of AI Communications 15(4), 205–215.Google Scholar
Wiesenfeld, K and Moss, F (1995) Stochastic resonance and the benefits of noise: from ice ages to crayfish and SQUIDS. Nature 373, 33–36.CrossRefGoogle ScholarPubMed
Wittmann, A and Korotev, R (2013) Iron-nickel-(cobalt) metal in lunar rocks revisited. In 44th Lunar & Planetary Science Conference, abstract no 3035.Google Scholar
Woese, C (1998) Universal ancestor. Proceedings of the National Academy of Sciences of the United States of America 95, 6854–6859.CrossRefGoogle ScholarPubMed
Wogan, T (2016) Ceramics made stronger with 3D printing. Chemistry World, 11 January 2016.Google Scholar
Wolfram, S (1985) Undecidability and intractability in theoretical physics. Physical Review Letters 54(8), 735–738.CrossRefGoogle ScholarPubMed
Wolfram, S (2002) A New Kind of Science. Champaign, IL: Wolfram Media.Google Scholar
Yamashita, Y and Nakamura, Y. (2007) Neuron circuit model with smooth nonlinear output function. In Proceedings of the International Symposium on Nonlinear Theory & its Applications, Vancouver, pp. 11–14.Google Scholar
Yildiz, A and Selvin, P (2005) Kinesin: walking, crawling or sliding along? Trends in Cell Biology 15(2), 112–120.CrossRefGoogle ScholarPubMed
Yue, Z, Johnson, B, Monton, D, Melosh, H, Di, K, Hu, W and Liu, Y (2013) Projectile remains in central peaks of lunar impact craters. Nature Geoscience 6, 435–437.CrossRefGoogle Scholar
Zakeri, B and Carr, P (2015) Limits of synthetic biology. Trends in Biotechnology 33(2), 57–58.CrossRefGoogle ScholarPubMed
Zuravlev, Y and Avetisov, V (2006) Definition of life in the context of its origins. Biogeosciences 3, 281–291.CrossRefGoogle Scholar
Zykov, V, Mytilinaios, E, Adams, B and Lipson, H (2005) Self-reproducing machines. Nature 435, 163–164.CrossRefGoogle ScholarPubMed