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Topical Mupirocin for Eradication of MRSA Colonization With Mupirocin-Resistant Strains

Published online by Cambridge University Press:  02 January 2015

Makeda Semret  and
Mark A. Miller
Makeda Semret
Affiliation:
Infection Prevention and Control Unit and Department of Microbiology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada
Mark A. Miller*
Affiliation:
Infection Prevention and Control Unit and Department of Microbiology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada
*
Department of Microbiology, SMBD-Jewish General Hospital, 3755 Cote Ste Catherine Rd, Montreal, Quebec H3T1E2, Canada
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Abstract

Topical mupirocin was able to interrupt colonization of 52% and 68% of methicillin-resistant Staphylococcus aureus (MRSA)-colonized patients carrying mupirocin-resistant and -sensitive strains, respectively, including 44.4% and 85.7% of those colonized only in the nares. Although a trend to decreased effectiveness was seen for clearing mupirocin-resistant MRSA this agent can decolonize many patients with resistant strains.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 22 , Issue 9 , September 2001 , pp. 578 - 580
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2001

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References

1.Bertino, JS Jr. Intranasal mupirocin for outbreaks of methicillin-resistant Staphylococcus aureus. Am J Health-Syst Pharm 1997;54:2185–2191.CrossRefGoogle ScholarPubMed
2.Miller, MA, Dascal, A, Portnoy, J, Mendelson, J. Development of mupirocin resistance among methiciHin resistant S aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 1996;17:811–813.CrossRefGoogle ScholarPubMed
3.Casewell, MW, Hill, RLR. Mupirocin (‘Pseudomonic add’): a promising new topical antimicrobial agent. J Antimicrob Chemother 1987;19:1–5.CrossRefGoogle Scholar
4.Fuchs, PC, Jones, RN, Barry, AL. Interpretative criteria for disk-diffusion susceptibility testing of mupirocin, a topical antibiotic. J Clin Microbiol 1990;28:608–609.CrossRefGoogle ScholarPubMed
5.Irish, D, Eltringham, I, Teall, A, Pickett, H, Farelly, H, Reith, S, et al. Control of an outbreak of an epidemic methicillin-resistant Staphylococcus aureus also resistant to mupirocin. J Hosp Infect 1998;39:19–26.CrossRefGoogle ScholarPubMed
6.Smith, MD, Sanghrajka, M, Lock, S. Mupirocin-resistant Staphylococcus aureus. Lancet 1987;ii:1472–1473.Google Scholar
7.Bradley, SF, Ramsey, MA, Morton, TM, Kauffman, CA. Mupirocin resistance: clinical and molecular epidemiology. Infect Control Hosp Epidemiol 1995;354–358.CrossRefGoogle ScholarPubMed
8.Scully, BE, Briones, F, Gu, JW, Neu, HC. Mupirocin treatment of nasal staphylococcal colonization. Arch Intern Med 1992;152:353–356.CrossRefGoogle ScholarPubMed
9.Kauffman, CA, Terpenning, MS, He, X, Zarins, LT, Ramsey, MA, Jorgensen, KA, et al. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long term facility with the use of mupirocin ointment. Am J Med 1993;94:371–378.CrossRefGoogle ScholarPubMed
10.Harbarth, S, Dharan, S, Liassine, N, Herrault, P, Auckenthaler, R, Pittet, D. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1999;43:1412–1416.CrossRefGoogle ScholarPubMed
11.Casewell, MW, Hill, RLR. Elimination of nasal carriage of Staphylococcus aureus with mupirocin (‘Pseudomonic acid’): a controlled trial. J Antimicrob Chemother 1986;17:365–372.CrossRefGoogle ScholarPubMed
12.Doebbeling, BN, Breneman, DL, Neu, HC, Aly, R, Yangco, BG, Holley, HP Jr, et al. Elimination of Staphylococcus aureus nasal carriage in healthcare workers: analysis of six clinical trials with calcium mupirocin ointment. Clin Infect Dis 1993;17:466–474.CrossRefGoogle ScholarPubMed