Hostname: page-component-f554764f5-fr72s Total loading time: 0 Render date: 2025-04-14T19:32:57.104Z Has data issue: false hasContentIssue false
  • English
  • Français

Systematic review of determinants influencing antibiotic prescribing for uncomplicated acute respiratory tract infections in adult patients at the emergency department

Published online by Cambridge University Press:  29 October 2020

Dwee Wee Lim Open the ORCID record for Dwee Wee Lim [Opens in a new window] ,
Htet Lin Htun ,
Lay See Ong ,
Huiling Guo  and
Angela Chow
Dwee Wee Lim
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and Knowledge (OCEAN), Tan Tock Seng Hospital, Singapore
Htet Lin Htun
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and Knowledge (OCEAN), Tan Tock Seng Hospital, Singapore
Lay See Ong
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and Knowledge (OCEAN), Tan Tock Seng Hospital, Singapore
Huiling Guo
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and Knowledge (OCEAN), Tan Tock Seng Hospital, Singapore
Angela Chow*
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and Knowledge (OCEAN), Tan Tock Seng Hospital, Singapore Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
*
Author for correspondence: Angela Chow, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Overuse of antibiotics in the emergency department (ED) for uncomplicated acute respiratory tract infections (uARTIs) is a public health issue that needs to be addressed. We aimed to identify factors associated with antibiotic use for uARTIs in adults presenting at the ED.

Design:

We searched Medline, Embase, PsycINFO and the Cochrane Library for articles published from 1 January 2005 to 30 June 2017 using a predetermined search strategy. Titles and abstracts of English articles on antibiotic prescription and inappropriate antibiotic use for adult ARTI at EDs were assessed, followed by full article review, by 2 authors.

Setting:

Emergency departments.

Participants:

Adults aged 18 years and older.

Results:

Of the 2,591 articles retrieved, 12 articles met the inclusion criteria and 11 studies were conducted in the United States. Patients with normal C-reactive protein levels and positive influenza tests were less likely to receive antibiotic treatment. Nonclinical factors associated with antibiotic use were longer waiting time and perceived patient desire for antibiotics. Patients attended by internal medicine physicians comanaged by house staff or who visited an ED which provided education to healthcare providers on antibiotics use were less likely to receive antibiotics.

Conclusions:

English-language articles that fulfilled the selection criteria outside the United States were limited. Factors associated with antibiotics use are multifaceted. Education of healthcare providers presents an opportunity to improve antibiotic use.

Type
Review
Information
Infection Control & Hospital Epidemiology , Volume 43 , Issue 3 , March 2022 , pp. 366 - 375
Check for updates
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Shapiro, DJ, Hicks, LA, Pavia, AT, Hersh, AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007–2009. J Antimicrob Chemother 2014;69:234–240.Google Scholar
Thorpe, JM, Smith, SR, Trygstad, TK. Trends in emergency department antibiotic prescribing for acute respiratory tract infections. Ann Pharmacother 2004;38:928–935.Google ScholarPubMed
Bergmark, RW, Sedaghat, AR. Antibiotic prescription for acute rhinosinusitis: emergency departments versus primary care providers. Laryngoscope 2016;126:2439–2444.Google ScholarPubMed
Donnelly, JP, Baddley, JW, Wang, HE. Antibiotic utilization for acute respiratory tract infections in US emergency departments. Antimicrob Agents Chemother 2014;58:1451–1457.Google Scholar
Grijalva, CG, Nuorti, JP, Griffin, MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA 2009;302:758–766.Google ScholarPubMed
Yoon, YK, Park, C-S, Kim, JW, et al. Guidelines for the antibiotic use in adults with acute upper respiratory tract infections. Infect Chemother 2017;49:326–352.Google ScholarPubMed
Palms, DL, Hicks, LA, Bartoces, M, et al. Comparison of antibiotic prescribing in retail clinics, urgent care centers, emergency departments, and traditional ambulatory care settings in the United States. JAMA Intern Med 2018;178:1267–1269.Google ScholarPubMed
Denny, KJ, Gartside, JG, Alcorn, K, Cross, JW, Maloney, S, Keijzers, G. Appropriateness of antibiotic prescribing in the emergency department. J Antimicrob Chemother 2019;74:515–520.Google ScholarPubMed
Llor, C, Bjerrum, L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 2014;5:229–241.Google ScholarPubMed
Costelloe, C, Metcalfe, C, Lovering, A, Mant, D, Hay, AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ 2010;340:c2096. doi: 10.1136/bmj.c2096.Google ScholarPubMed
Pourmand, A, Mazer-Amirshahi, M, Jasani, G, May, L. Emerging trends in antibiotic resistance: implications for emergency medicine. Am J Emerg Med 2017;35:1172–1176.Google ScholarPubMed
Budnitz, DS, Pollock, DA, Weidenbach, KN, Mendelsohn, AB, Schroeder, TJ, Annest, JL. National surveillance of emergency department visits for outpatient adverse drug events. JAMA 2006;296:1858–1866.Google ScholarPubMed
Kenealy, T, Arroll, B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev 2013;6:CD000247.Google Scholar
Thong, BY-H, Tan, T-C. Epidemiology and risk factors for drug allergy. Br J Clin Pharmacol 2011;71:684–700.Google ScholarPubMed
McKay, R, Mah, A, Law, MR, McGrail, K, Patrick, DM. Systematic review of factors associated with antibiotic prescribing for respiratory tract infections. Antimicrob Agents Chemother 2016;60:4106–4118.Google ScholarPubMed
O’Connor, R, O’Doherty, J, O’Regan, A, Dunne, C. Antibiotic use for acute respiratory tract infections (ARTI) in primary care; what factors affect prescribing and why is it important? A narrative review. Ir J Med Sci 2018;187:969–986.Google ScholarPubMed
Newton, EH. Addressing overuse in emergency medicine: evidence of a role for greater patient engagement. Clin Exp Emerg Med 2017;4:189–200.Google Scholar
Pun, JKH, Matthiessen, CMIM, Murray, KA, Slade, D. Factors affecting communication in emergency departments: doctors and nurses’ perceptions of communication in a trilingual ED in Hong Kong. Int J Emerg Med 2015;8:48.Google Scholar
Higgins, JP, Green, S. Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. Hoboken, NJ: John Wiley & Sons; 2011. https://handbook-5-1.cochrane.org/. Accessed May 23, 2020.Google Scholar
Aspinall, SL, Good, CB, Metlay, JP, Mor, MK, Fine, MJ. Antibiotic prescribing for presumed nonbacterial acute respiratory tract infections. Am J Emerg Med 2009;27:544–551.Google ScholarPubMed
Fee, C, Metlay, JP, Camargo, CA, Maselli, JH, Gonzales, R. ED antibiotic use for acute respiratory illnesses since pneumonia performance measure inception. Am J Emerg Med 2010;28:23–31.Google ScholarPubMed
Xu, KT, Roberts, D, Sulapas, I, Martinez, O, Berk, J, Baldwin, J. Overprescribing of antibiotics and imaging in the management of uncomplicated URIs in emergency departments. BMC Emerg Med 2013;13:7.Google Scholar
Gonzales, R, Camargo, CA, MacKenzie, T, et al. Antibiotic treatment of acute respiratory infections in acute-care settings. Acad Emerg Med 2006;13:288–294.Google ScholarPubMed
Gonzales, R, Aagaard, EM, Camargo, CA, et al. C-reactive protein testing does not decrease antibiotic use for acute cough illness when compared to a clinical algorithm. J Emerg Med 2011;41:1–7.Google Scholar
Jun, S-H, Kim, J-Y, Yoon, Y-H, Lim, C-S, Ch, H-J, Choi, S-H. The effect of the rapid antigen test for influenza on clinical practice in the emergency department: a comparison of periods before and after the 2009 H1N1 influenza pandemic. Signa Vitae 2016;11:74–89.Google Scholar
Metlay, JP, Camargo, CA, MacKenzie, T, et al. Cluster-randomized trial to improve antibiotic use for adults with acute respiratory infections treated in emergency departments. Ann Emerg Med 2007;50:221–230.Google ScholarPubMed
Stearns, CR, Gonzales, R, Camargo, CA, Maselli, J, Metlay, JP. Antibiotic prescriptions are associated with increased patient satisfaction with emergency department visits for acute respiratory tract infections. Acad Emerg Med 2009;16:934–941.Google ScholarPubMed
May, L, Gudger, G, Armstrong, P, et al. Multisite exploration of clinical decision making for antibiotic use by emergency medicine providers using quantitative and qualitative methods. Infect Control Hosp Epidemiol 2014;35:1114–1125.Google ScholarPubMed
Roumie, CL, Halasa, NB, Edwards, KM, Zhu, Y, Dittus, RS, Griffin, MR. Differences in antibiotic prescribing among physicians, residents, and nonphysician clinicians. Am J Med 2005;118:641–648.Google ScholarPubMed
Kroening-Roche, JC, Soroudi, A, Castillo, EM, Vilke, GM. Antibiotic and bronchodilator prescribing for acute bronchitis in the emergency department. J Emerg Med 2012;43:221–227.Google ScholarPubMed
Gonzales, R, Anderer, T, McCulloch, CE, et al. A cluster-randomized trial of decision support strategies for reducing antibiotic use for acute bronchitis. JAMA Intern Med 2013;173:267–273.Google ScholarPubMed
Davey, P, Marwick, CA, Scott, CL, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2017;2. doi: 10.1002/14651858.CD003543.pub4.Google ScholarPubMed
Ranji, SR, Steinman, MA, Shojania, KG, Gonzales, R. Interventions to reduce unnecessary antibiotic prescribing: a systematic review and quantitative analysis. Med Care 2008;46:847–862.Google ScholarPubMed
Charani, E, Ahmad, R, Rawson, TM, Castro-Sanchèz, E, Tarrant, C, Holmes, AH. The differences in antibiotic decision making between acute surgical and acute medical teams: an ethnographic study of culture and team dynamics. Clin Infect Dis 2018. doi: 10.1093/cid/ciy844.Google Scholar
Saposnik, G, Redelmeier, D, Ruff, CC, Tobler, PN. Cognitive biases associated with medical decisions: a systematic review. BMC Med Inform Decis Mak 2016;16:138.Google ScholarPubMed
Pynnonen, MA, Lynn, S, Kern, HE, et al. Diagnosis and treatment of acute sinusitis in the primary care setting: a retrospective cohort. Laryngoscope 2015;125:2266–2272.Google ScholarPubMed
Croskerry, P, Petrie, DA, Reilly, JB, Tait, G. Deciding about fast and slow decisions. Acad Med 2014;89:197–200.Google ScholarPubMed
Audétat, M-C, Laurin, S, Dory, V, Charlin, B, Nendaz, MR. Diagnosis and management of clinical reasoning difficulties: Part II. Clinical reasoning difficulties: management and remediation strategies. Med Teach 2017;39:797–801.Google ScholarPubMed
Sore throat (acute): antimicrobial prescribing. National Institute for Health and Care Excellence website. https://www.nice.org.uk/guidance/ng84. Published January 26, 2018. Accessed May 18, 2019.Google Scholar
Smith, SM, Fahey, T, Smucny, J, Becker, LA. Antibiotics for acute bronchitis. Cochrane Database Syst Rev 2017;6:CD000245. doi: 10.1002/14651858.CD000245.pub4.Google ScholarPubMed
Rosenfeld, RM, Piccirillo, JF, Chandrasekhar, SS, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg 2015;152 suppl 2:S1–S39.Google Scholar
Morgan, SR, Chang, AM, Alqatari, M, Pines, JM. Non-emergency department interventions to reduce ED utilization: a systematic review. Acad Emerg Med 2013;20:969–985.Google ScholarPubMed
Dempsey, PP, Businger, AC, Whaley, LE, Gagne, JJ, Linder, JA. Primary care clinicians’ perceptions about antibiotic prescribing for acute bronchitis: a qualitative study. BMC Fam Pract 2014;15. doi: 10.1186/s12875-014-0194-5.Google ScholarPubMed
Gaarslev, C, Yee, M, Chan, G, Fletcher-Lartey, S, Khan, R. A mixed methods study to understand patient expectations for antibiotics for an upper respiratory tract infection. Antimicrob Resist Infect Control 2016;5:39.Google ScholarPubMed
Sharp, AL, Shen, E, Kanter, MH, Berman, LJ, Gould, MK. Low-value antibiotic prescribing and clinical factors influencing patient satisfaction. Am J Manag Care 2017;23:589–594.Google ScholarPubMed
van Driel, ML, De Sutter, A, Deveugele, M, et al. Are sore throat patients who hope for antibiotics actually asking for pain relief? Ann Fam Med 2006;4:494–499.Google ScholarPubMed
Supplementary material: File

Lim et al. supplementary material

Lim et al. supplementary material

Download Lim et al. supplementary material(File)
File 26.6 KB