Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-26T09:11:19.512Z Has data issue: false hasContentIssue false

Spread of Vancomycin-Resistant Enterococci: Differences Between the United States and Europe

Published online by Cambridge University Press:  02 January 2015

Herman Goossens*
Affiliation:
Department of Microbiology, University Hospital Antwerp, Edegem-Antwerp, Belgium
*
University Hospital Antwerp, Wilrijk straat, 10, 2650 Edegem-Antwerp, Belgium

Abstract

There are major differences in the epidemiology of vancomycin-resistant enterococci (VRE) between the United States and Europe. In contrast with Europe, VRE in the United States are resistant to many antibiotics, and there appears to be less genetic variability among these isolates. European VRE of human origin are usually susceptible to many other antibiotics and are highly polyclonal. These clinical isolates have the same susceptibility profiles as VRE isolated from animals.

The differences in the spread of VRE between the United States and Europe might be explained by the overconsumption of glycopeptides and other antibiotics in hospitals in the United States and the use of avoparcin as a growth promotor in Europe.

Type
From the Fifth International Conference on the Prevention of Infection
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Leclercq, R, Derlot, E, Duval, J, Courvalin, P. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium . N Engl J Med 1988;319:157161.Google Scholar
2. Jones, RN, Sader, HS, Erwin, ME, Anderson, SC, and the Enterococcus Study Group. Emerging multiple resistant enterococci among clinical isolates: I, prevalence data from 97 medical center surveillance study in the United States. Diagn Microbiol Infect Dis 1995;21:8593.Google Scholar
3. Morris, JG Jr, Shay, DK, Hebden, JN, McCarter, RJ Jr, Perdue, BE, Jarvis, W, et al. Enterococci resistant to multiple antimicrobial agents, including vancomycin. Establishment of endemicity in a university medical center. Ann Intern Med 1995;123:250259.Google Scholar
4. Quale, J, Landman, D, Saurina, G, Atwood, E, DiTore, V, Patel, K. Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci. Clin Infect Dis 1996;23:10201025.Google Scholar
5. Wells, CL, Juni, BA, Cameron, SB. Stool carriage, clinical isolation and mortality during an outbreak of vancomycin-resistant enterococci in hospitalized medical and/or surgical patients. Clin Infect Dis 1995;21:4550.Google Scholar
6. Vandamme, P, Vercauteren, E, Lammens, C, Pensart, N, Ieven, M, Pot, B, et al. Survey of enterococcal susceptibility patterns in Belgium. J Clin Microbiol 1996;34:25722576.Google Scholar
7. Boisivon, A, Thibault, M, Leclercq, R. Colonization by vancomycin-resistant enterococci of the intestinal tract of patients in intensive care units from French general hospitals. Clinical Microbiology and Infection 1996;3:175179.CrossRefGoogle Scholar
8. Klare, I, Heier, H, Claus, H, Böhme, G, Marin, S, Seitmann, G, et al. Enterococcus faecium strains with vanA mediated high level resistance isolated from animal foodstuffs and fecal samples of humans in the community. Microbial Drug Resistance 1995;1:265272.Google Scholar
9. Gordts, B, Van Landuyt, H, Ieven, M, Vandamme, P, Goossens, H. Vancomycin-resistant enterococci colonizing the intestinal tracts of hospitalized patients. J Clin Microbiol 1995;33:28422846.CrossRefGoogle ScholarPubMed
10. Jordens, JZ, Bates, J, Griffiths, DT. Faecal carriage and nosocomial spread of vancomycin-resistant Enterococcus faecium . J Antimicrob Chemother 1994;34:515528.Google Scholar
11. Endtz, HP, van den Braak, N, van Belkum, A, Kluytmans, AJW, Koeleman, JGM, Spanjaard, M, et al. Fecal carriage of vancomycin resistant enterococci in hospitalized patients and those living in the community in The Netherlands. J Clin Microbiol 1997;35:30263031.Google Scholar
12. Coque, TM, Tomayko, JF, Ricke, SC, Okhyusen, PC, Murray, BE. Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States. Antimicrob Agents Chemother 1996;40:26052609.CrossRefGoogle ScholarPubMed
13. Silverman, J, Thal, LA, Perri, MB, Bostic, G, Zervos, MJ. Epidemiologic evaluation of antimicrobial resistance in community-acquired enterococci. J Clin Microbiol 1998;36:830832.Google Scholar
14. Devriese, LA, Ieven, M, Goossens, H, Vandamme, P, Pot, B, Hommez, J, et al. Presence of vancomycin-resistant enterococci in farm and pet animals. Antimicrob Agents Chemother 1996;40:22852287.Google Scholar
15. Ieven, M, Vercauteren, E, Descheemaeker, P, Goossens, H. Significant increase in detection of intestinal carriers of glycopeptide resistant ente-rococci (GRE) by enrichment cultures. Presented at the 37th International Conference on Antimicrobial Agents and Chemotherapy; 1997; Toronto, Ontario, Canada, 1997:104. Abstract D-118.Google Scholar
16. Van der Auwera, P, Pensart, N, Korten, V, Murray, BE, Leclercq, R. Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci. J Infect Dis 1996;173:11291136.Google Scholar
17. Boyle, JF, Soumakis, SA, Rendo, A, Herrington, JA, Gianarkis, DG, Thurberg, BE, et al. Epidemiologic analysis and genotypic characterization of a nosocomial outbreak of vancomycin-resistant enterococci. J Clin Microbiol 1993;31:12801285.Google Scholar
18. Iwen, PC, Kelly, DM, Linder, J, Hinrichs, SH, Dominguez, EA, Rupp, ME, et al. Change in prevalence and antibiotic resistance of Enterococcus species isolated from blood cultures over an 8-year period. Antimicrob Agents Chemother 1997;41:494495.Google Scholar
19. Goossens, H, Lammens, C, Goossens, W, Vandamme, P, Ieven, M, Strue-lens M. Multicenter in-vitro evaluation of the susceptibility of 1,342 gram-positive cocci isolated from the blood towards cefepime and cef-pirome compared to other antibiotics. Presented at the 37th International Conference on Antimicrobial Agents and Chemotherapy; 1997; Toronto, Ontario, Canada, 1997:137. Abstract E-130.Google Scholar
20. Gordon, S, Swenson, JM, Hill, BC, Pigott, NE, Facklam, RR, Cooksey, RC, et al. Antimicrobial susceptibility patterns of common and unusual species of enterococci causing infections in the United States. J Clin Microbiol 1992;30:23732378.Google Scholar
21. Nachamkin, I, Axelrod, P, Talbot, GH, Fischer, SH, Wennersten, CB, Moellering, RC. Multiply high-level aminoglycoside-resistant enterococci isolated from patients in a university hospital. J Clin Microbiol 1988;26:12871291.CrossRefGoogle ScholarPubMed
22. Noskin, GA, Till, M, Patterson, BK, Clarke, JT, Warren, JR. High-level gentamicin resistance in Enterococcus faecalis bacteremia. J Infect Dis 1991;164:12121215.Google Scholar
23. Wurtz, R, Sahm, D, Flaherty, J. Gentamicin-resistant, streptomycin-susceptible Enterococcus (Streptococcus) faecalis bacteremia. J Infect Dis 1991;163:13931394.Google Scholar
24. Coque, TM, Arduino, RC, Murray, BE. High-level resistance to aminogly-cosides: comparison of nosocomial fecal isolates of enterococci. J Infect Dis 1995;20:10481051.Google Scholar
25. Gray, JW, Stewart, D, Pedler, SJ. Faecal carriage of antibiotic-resistant enterococci in hospitalized and non-hospitalized individuals. J Antimicrob Chemother 1992;30:110112.CrossRefGoogle ScholarPubMed
26. Schaberg, DR, Dillon, WI, Terpenning, MS, Robinson, KA, Bradley, SF, Kauffman, CA. Increasing resistance of enterococci to ciprofloxacin. Antimicrob Agents Chemother 1992;36:25332535.Google Scholar
27. Clark, NC, Cooksey, RC, Hill, BC, Swenson, JM, Tenover, FC. Characterization of glycopeptide-resistant enterococci from US hospitals. Antimicrob Agents Chemother 1993;37:23112317.Google Scholar
28. Frieden, TR, Munsiff, SS, Low, DE, Willey, BM, Williams, G, Faur, Y, et al. Emergence of vancomycin-resistant enterococci in New York City. Lancet 1993;342:7679.Google Scholar
29. Rice, EW, Messer, JW, Johnson, CH, Reasoner, DJ. Occurrence of highlevel aminoglycoside resistance in environmental isolates of enterococci. Appl Environ Microbiol 1995;61:374376.Google Scholar
30. Thal, LA, Chow, JW, Mahayni, R, Bonilla, H, Perri, MB, Donabedian, SA, et al. Characterization of antimicrobial resistance in enterococci of animal origin. Antimicrob Agents Chemother 1995;39:21122115.Google Scholar
31. Descheemaeker, P, Chapelle, S, Devriese, LA, Vandamme, P, Goossens, H. Transfer of Tn 1546 or related elements, conferring high level glycopeptide resistance among enterococci from animal and human origin. Presented at the Fifth American Society of Microbiology Conference on Streptococcal Genetics; 04 26-29, 1998; Vichy, France.Google Scholar
32. Aarestrup, FM, Ahrens, P, Madsen, M, Pallesen, LV, Poulsen, RL, Westh, H. Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the vanA cluster. Antimicrob Agents Chemother 1996;40:19381940.CrossRefGoogle ScholarPubMed
33. Handwerger, S, Raucher, B, Altarac, D, Monka, J, Marchione, S, Singh, KV, et al. Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin Infect Dis 1993;16:750755.Google Scholar
34. Boyce, JM, Opal, SM, Chow, JW, Zervos, MJ, Potter-Bynoe, G, Sherman, CB, et al. Outbreak of multidrug-resistant Enterococcus faecium with transferable vanB class vancomycin resistance. J Clin Microbiol 1994;32:11481153.Google Scholar
35. Moreno, F, Grota, P, Grisp, C, Magnon, K, Melcher, GP, Jorgensen, JH, et al. Clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium during its emergence in a city in southern Texas. Clin Infect Dis 1995;21:12341237.Google Scholar
36. Dunne, WM Jr, Wang, W. Clonal dissemination and colony morphotype variation of vancomycin-resistant Enterococcus faecium isolates in metropolitan Detroit, Michigan. J Clin Microbiol 1997;35:388392.Google Scholar
37. Bonten, MJM, Hayden, MK, Nathan, C, van Voorhis, J, Matushek, M, Slaughter, S, et al. Epidemiology of colonisation of patients and environment with vancomycin-resistant enterococci. Lancet 1996;348:16151619.CrossRefGoogle ScholarPubMed
38. Gordts, B, Van Landuyt, H, Lambert, A, Ieven, M, Goossens, H. Specific in vitro resistance patterns of glycopeptide resistant enterococci (GRE) collected in a national surveillance study. Presented at the 37th International Conference on Antimicrobial Agents and Chemotherapy; 1997; Toronto, Ontario, Canada, 1997:137. Abstract E-129.Google Scholar
39. Bingen, EH, Denamur, E, Lambert-Zechovsky, NJ, Elion, J. Evidence for genetic unrelatedness of nosocomial outbreak of vancomycin-resistant Enterococcus faecium strains in a pediatric hospital. J Clin Microbiol 1991;29:18881892.Google Scholar
40. Rao, GG, Ojo, F, Kolokithas, D. Vancomycin-resistant gram-positive cocci: risk factors for faecal carriage. J Hosp Infect 1997;35:6369.Google Scholar
41. Pegues, DA, Pegues, CF, Hibberd, PL, Ford, DS, Hooper, DC. Emergence and dissemination of a highly vancomycin-resistant vanA strain of Enterococcus faecium at a large teaching hospital. J Clin Microbiol 1997;35:15651570.Google Scholar
42. Edmond, MB, Ober, JF, Weinbaum, DL, Pfaller, MA, Hwang, T, Sanford, MD, Wenzel, RP. Vancomycin-resistant Enterococcus faecium bacteremia: risk factors for infection. Clin Infect Dis 1995;20:11261133.Google Scholar
43. Livornese, LL Jr, Dias, S, Samel, C, Romanowski, B, Taylor, S, May, P, et al. Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers. Ann Intern Med 1992;117:112116.Google Scholar
44. Kirst, HA, Thompson, DG, Nicas, TI. Historical yearly usage of vancomycin. Antimicrob Agents Chemother 1998;42:13031304.Google Scholar
45. Biavasco, F, Miele, A, Vignaroli, C, Manso, E, Lupidi, R, Varaldo, PE. Genotypic characterization of a nosocomial outbreak of vanA Enterococcus faecalis . Microbial Drug Resistance 1996;2:231237.Google Scholar
46. Boyce, JM, Opal, SM, Potter-Bynoe, G, LaForge, RG, Zervos, MJ, Furtado, G, et al. Emergence and nosocomial transmission of ampicillin-resistant enterococci. Antimicrob Agents Chemother 1992;36:10321039.Google Scholar
47. Boyce, JM, Mermel, LA, Zervos, MJ, Rice, LB, Potter-Bynoe, G, Giorgio, C, et al. Controlling vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 1995;16:634637.Google Scholar
48. Mato, R, De Lencastre, H, Roberts, RB, Tomasz, A. Multiplicity of genetic backgrounds among vancomycin-resistant Enterococcus faecium isolates recovered from an outbreak in a New York City hospital. Microb Drug Res 1996;2:309317.Google Scholar
49. Grayson, ML, Eliopoulos, GM, Wennersten, CB, Ruoff, KL, De Girolami, PC, Ferraro, MJ, et al. Increasing resistance to ß-lactam antibiotics among clinical isolates of Enterococcus faecium: a 22-year review at one institution. Antimicrob Agents Chemother 1991;35:21802184.Google Scholar
50. Fridkin, SK, Ykoe, DS, Whitney, CG, Onderdonk, A, Hooper, D. Epidemiology of a dominant clonal strain of vancomycin-resistant Enterococcus faecium at separate hospitals in Boston, Massachusetts. J Clin Microbiol 1998;36:965970.Google Scholar
51. Descheemaeker, P, Ieven, M, Chapelle, S, Lammens, C, Hauchecorne, M, Wijdooghe, M, et al. Epidemiology of vancomycin resistant enterococci in Belgian renal dialysis patients. Presented at the Fifth American Society of Microbiology Conference on Streptococcal Genetics; 04 26-29, 1998; Vichy, France.Google Scholar