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Serratia marcescans Contamination of Antiseptic Soap Containing Triclosan: Implications for Nosocomial Infection

Published online by Cambridge University Press:  02 January 2015

M. Anita Barry ,
Donald E. Craven ,
Theresa A. Goularte  and
Deborah A. Lichtenberg
M. Anita Barry
Affiliation:
Department of Medicine, Division of Infectious Disease, Boston University School of Medicine, Boston City Hospital, Boston, Massachusetts
Donald E. Craven*
Affiliation:
Department of Medicine, Division of Infectious Disease, Boston University School of Medicine, Boston City Hospital, Boston, Massachusetts
Theresa A. Goularte
Affiliation:
Department of Medicine, Division of Infectious Disease, Boston University School of Medicine, Boston City Hospital, Boston, Massachusetts
Deborah A. Lichtenberg
Affiliation:
Department of Medicine, Division of Infectious Disease, Boston University School of Medicine, Boston City Hospital, Boston, Massachusetts
*
Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston, MA 02118
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Abstract

During a recent investigation in our surgical intensive care unit, we found that several bottles of the antiseptic handwashing soap, OR Scrub®, were contaminated with Serratia marcescens. OR Scrub® contains 1% triclosan, lanolin, and detergents. The antimicrobial efficacy of OR Scrub® was examined in vitro using serial two-fold dilutions of soap inoculated with various concentrations of different nosocomial pathogens. The minimal bactericidal concentration (MBC) of OR Scrub® against Pseudomonas aeruginosa and several strains of S. marcescens was ≤1:2 By comparison, a non-antiseptic soap from the same manufacturer (Wash®) and 4% chlorhexidine (Hibiclens®) had MBCs for all strains tested of at least 1:64. Time-kill curves confirmed the findings of the initial experiments.

This is the first report of extrinsic contamination of antiseptic soap containing triclosan. No infections could be attributed to the contaminated soap, but sporadic outbreaks of Serratia have occurred in the intensive care unit with no identifiable source. Although there have been few studies on the impact of antiseptic soap in reducing nosocomial infection, we question whether a soap with the limitations of OR Scrub® should be used in intensive care units or operating rooms.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 5 , Issue 9 , September 1984 , pp. 427 - 430
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1984

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