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Risk of MRSA Infection in Patients with Intermittent versus Persistent MRSA Nares Colonization

Published online by Cambridge University Press:  20 August 2015

Daniel I. Vigil ,
Wesley D. Harden ,
Anne E. Hines ,
Patrick W. Hosokawa ,
William G. Henderson  and
Mary T. Bessesen
Daniel I. Vigil*
Affiliation:
University of Colorado, Preventive Medicine Residency, Aurora, Colorado
Wesley D. Harden
Affiliation:
University of Colorado, Preventive Medicine Residency, Aurora, Colorado
Anne E. Hines
Affiliation:
Veterans Health Administration Eastern Colorado Healthcare System, Infectious Disease, Denver, Colorado
Patrick W. Hosokawa
Affiliation:
University of Colorado, Adult and Child Center for Outcomes Research and Delivery Science, Aurora, Colorado
William G. Henderson
Affiliation:
University of Colorado, Adult and Child Center for Outcomes Research and Delivery Science, Aurora, Colorado
Mary T. Bessesen
Affiliation:
Veterans Health Administration Eastern Colorado Healthcare System, Infectious Disease, Denver, Colorado University of Colorado Department of Medicine, Division of Infectious Diseases, Aurora, Colorado
*
Address correspondence to Daniel Vigil, MD, University of Colorado Preventive Medicine Residency, 13001 E. 17th Place, Campus Box B119, Aurora, CO 80045 ([email protected]).
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Abstract

OBJECTIVE

To determine the relative risk of invasive methicillin-resistant Staphylococcus aureus (MRSA) infection among non-colonized (NC) patients, intermittently colonized (IC) patients, and persistently colonized (PC) patients.

DESIGN

Observational cohort study of patient data collected longitudinally over a 41-month period.

SETTING

Department of Veterans Affairs Eastern Colorado Healthcare System, a tertiary care medical center.

PATIENTS

Any patient who received ≥5 MRSA nasal swab tests between February 20, 2010, and July 26, 2013. In total, 3,872 patients met these criteria, 0 were excluded, 95% were male, 71% were white, and the mean age was 62.9 years on the date of study entry.

METHODS

Patients were divided into cohorts based on MRSA colonization status. Physicians reviewed medical records to identify invasive infection and were blinded to colonization status. Cox and Kaplan-Meier analyses were used to assess the relationship between colonization status and invasive infection.

RESULTS

In total, 102 patients developed invasive MRSA infections, 16.3% of these were PC patients, 11.2% of these were IC patients, and 0.5% of these were NC patients. PC patients were at higher risk of invasive infection than NC patients (hazard ratio [HR] 36.8; 95% CI, 18.4–73.6; P<.001). IC patients were also at higher risk than NC patients (HR, 22.8; 95% CI, 13.3–39.3; P<.001). The difference in risk between PC and IC patients was not statistically significant (HR, 1.61; 95% CI, 0.94–2.78, P=.084). Alternate analysis methods confirmed these results.

CONCLUSIONS

The risk of invasive MRSA infection is much higher among PC and IC patients, supporting routine clinical testing for colonization. However, this risk is similar among PC and IC patients, suggesting that distinguishing between the 2 colonization states may not be clinically important.

Infect. Control Hosp. Epidemiol. 2015;36(11):1292–1297

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 36 , Issue 11 , November 2015 , pp. 1292 - 1297
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION The results of this study were displayed in a poster presentation at IDWeek 2014, October 8–12, Philadelphia, Pennsylvania.

References

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