Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-25T08:19:52.921Z Has data issue: false hasContentIssue false

Risk of Clostridium difficile Infection in Hematology-Oncology Patients Colonized With Toxigenic C. difficile

Published online by Cambridge University Press:  11 April 2017

Cara M. Cannon
Affiliation:
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Jackson S. Musuuza
Affiliation:
Institute of Clinical and Translational Research, University of Wisconsin, Madison, Wisconsin William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin.
Anna K. Barker
Affiliation:
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Megan Duster
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Mark B. Juckett
Affiliation:
Division of Hematology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Aurora E. Pop-Vicas
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Nasia Safdar*
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin.
*
Address correspondence to Nasia Safdar, MD, PhD, UWMF Centennial Building, 1685 Highland Avenue, Madison, WI 53705 ([email protected]).

Abstract

The prevalence of colonization with toxigenic Clostridium difficile among patients with hematological malignancies and/or bone marrow transplant at admission to a 566-bed academic medical care center was 9.3%, and 13.3% of colonized patients developed symptomatic disease during hospitalization. This population may benefit from targeted C. difficile infection control interventions.

Infect Control Hosp Epidemiol 2017;38:718–720

Type
Concise Communications
Copyright
© 2017 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

PREVIOUS PRESENTATION. These data were presented in abstract form at the SHEA conference, Atlanta, Georgia on May 19, 2016.

References

REFERENCES

1. Cohen, SH, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431455.Google Scholar
2. Warrack, S, Duster, M, Van Hoof, S, Schmitz, M, Safdar, N. Clostridium difficile in a children’s hospital: assessment of environmental contamination. Am J Infect Control 2014;42:802804.Google Scholar
3. Jain, T, Croswell, C, Urday-Cornejo, V, et al. Clostridium difficile colonization in hematopoietic stem cell transplant recipients: a prospective study of the epidemiology and outcomes involving toxigenic and nontoxigenic strains. Biol Blood Marrow Transplant 2016;22:157163.CrossRefGoogle ScholarPubMed
4. Bruminhent, J, Wang, ZX, Hu, C, et al. Clostridium difficile colonization and disease in patients undergoing hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2014;20:13291334.Google Scholar
5. Zacharioudakis, IM, Zervou, FN, Pliakos, EE, Ziakas, PD, Mylonakis, E. Colonization with toxinogenic C. difficile upon hospital admission, and risk of infection: a systematic review and meta-analysis. Am J Gastroenterol 2015;110:381390.CrossRefGoogle ScholarPubMed
6. Selvey, LA, Slimings, C, Joske, DJ, Riley, TV. Clostridium difficile infections amongst patients with haematological malignancies: a data linkage study. PLoS One 2016;11:e0157839.Google Scholar
7. Lanzas, C, Dubberke, ER. Effectiveness of screening hospital admissions to detect asymptomatic carriers of Clostridium difficile: a modeling evaluation. Infect Control Hosp Epidemiol 2014;35:10431050.Google Scholar
8. Johnson, S, Sambol, SP, Brazier, JS, et al. International typing study of toxin A-negative, toxin B-positive Clostridium difficile variants. J Clin Microbiol 2003;41:15431547.Google Scholar
9. Kallen, AJ, Thompson, A, Ristaino, P, et al. Complete restriction of fluoroquinolone use to control an outbreak of Clostridium difficile infection at a community hospital. Infect Control Hosp Epidemiol 2009;30:264272.Google Scholar
10. Owens, RC Jr, Donskey, CJ, Gaynes, RP, Loo, VG, Muto, CA. Antimicrobial-associated risk factors for Clostridium difficile infection. Clin Infect Dis 2008;46:S19S31.CrossRefGoogle ScholarPubMed