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Risk Factors for Infection and Molecular Typing in Patients in the Intensive Care Unit Colonized with Nosocomial Enterobacter Aerogenes

Published online by Cambridge University Press:  02 January 2015

Michael Piagnerelli ,
Eric Carlier ,
Ariane Deplano ,
Philippe Lejeune  and
Danielle Govaerts
Michael Piagnerelli
Affiliation:
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
Eric Carlier
Affiliation:
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
Ariane Deplano
Affiliation:
Department of Microbiology, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
Philippe Lejeune
Affiliation:
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
Danielle Govaerts*
Affiliation:
Department of Microbiology, André Vésale Hospital, Montigny-le-Tilleul, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
*
Department of Microbiology, André Vésale Hospital 706, route de Gozée 6110, Montigny-le-Tilleul, Belgium
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Abstract

Objectives:

To determine the frequency of colonization by Enterobacter aerogenes in patients in the intensive care unit (ICU) for more than 48 hours and to evaluate the risk factors for infection in patients colonized by this bacteria.

Design:

An 8-month prospective study.

Setting:

A 12-bed medical–surgical ICU in a 450-bed, university-affiliated, tertiary-care hospital in Belgium.

Method:

Pulsed-field gel electrophoresis was used to determine the genotypes of E. aerogenes isolates.

Results:

We observed two major clones of E. aerogenes in the ICU. Interestingly, 87.5% of infected patients had the same genomic profile for colonization and infection. Risk factors for infection in this particular population included younger age, prolonged hospital stay, mechanical ventilation, and bronchoscopy.

Conclusions:

Colonization is a major prerequisite for infection. The identification of risk factors for infection in colonized patients can optimize the quality of treatment in the ICU.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 23 , Issue 8 , August 2002 , pp. 452 - 456
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2002

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