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Review of Clinical Trials of Skin Antiseptic Agents Used to Reduce Blood Culture Contamination

Published online by Cambridge University Press:  02 January 2015

Anurag Malani ,
Kim Trimble ,
Vikas Parekh ,
Carol Chenoweth ,
Samuel Kaufman  and
Sanjay Saint
Anurag Malani*
Affiliation:
Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan
Kim Trimble
Affiliation:
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Vikas Parekh
Affiliation:
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Carol Chenoweth
Affiliation:
Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Samuel Kaufman
Affiliation:
Patient Safety Enhancement Program, University of Michigan Medical School, Ann Arbor, Michigan Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Sanjay Saint
Affiliation:
Health Services Research and Development Service, University of Michigan Medical School, Ann Arbor, Michigan Patient Safety Enhancement Program, University of Michigan Medical School, Ann Arbor, Michigan Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan
*
Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Rd., Ann Arbor, MI 48105 ([email protected])
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Abstract

False-positive blood culture results may lead to prolonged hospitalization, inappropriate antibiotic administration, and increased healthcare costs. We conducted a review of the literature to assess the effect of skin antiseptic agents on the rate of false-positive blood culture Results. We found no clear evidence to suggest which antiseptic should be used to prevent false-positive Results. Studies suggest, however, a possible benefit from the use of prepackaged skin antiseptic kits and alcohol-containing antiseptics.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 7 , July 2007 , pp. 892 - 895
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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References

1.Weinstein, MP. Blood culture contamination: persisting problems and partial progress. J Clin Microbiol 2003;41:2275–2278.CrossRefGoogle ScholarPubMed
2.Bates, DW, Goldman, L, Lee, TH. Contaminant blood cultures and resource utilization: the true consequences of false-positive Results. JAMA 1991;265:365–369.CrossRefGoogle ScholarPubMed
3.Little, JR, Murray, PR, Traynor, PS, Spitznagel, E. A randomized trial of povidone-iodine compared with iodine tincture for venipuncture site disinfection: effects on rates of blood culture contamination. Am J Med 1999;107:119–125.CrossRefGoogle ScholarPubMed
4.Surdulescu, S, Utamsingh, D, Shekar, R. Phlebotomy teams reduce blood-culture contamination rate and save money. Clin Perform Qual Health Care 1998;6:60–62.Google ScholarPubMed
5.Washington, JA II, Ilstrup, DM. Blood cultures: issues and controversies. Rev Infect Dis 1986;8:792–802.CrossRefGoogle ScholarPubMed
6.Calfee, DP, Farr, BM. Comparison of four antiseptic preparations for skin in the prevention of contamination of percutaneously drawn blood cultures: a randomized trial. J Clin Microbiol 2002;40:1660–1665.CrossRefGoogle ScholarPubMed
7.Mimoz, O, Karim, A, Mercat, A, et al.Chlorhexidine compared with povidone-iodine as skin preparation before blood culture: a randomized, controlled trial. Ann Intern Med 1999;131:834–837.CrossRefGoogle ScholarPubMed
8.Trautner, BW, Clarridge, IE, Darouiche, RO. Skin antisepsis kits containing alcohol and Chlorhexidine gluconate or tincture of iodine are associated with low rates of blood culture contamination. Infect Control Hosp Epidemiol 2002;23:397–401.CrossRefGoogle ScholarPubMed
9.Strand, CL, Wajsbort, RR, Sturmann, K. Effect of iodophor vs iodine tincture skin preparation on blood culture contamination rate. JAMA 1993;269:1004–1006.CrossRefGoogle ScholarPubMed
10.Weinbaum, FI, Lavie, S, Danek, M, Sixsmith, D, Heinrich, GF, Mills, SS. Doing it right the first time: quality improvement and the contaminant blood culture. J Clin Microbiol 1997;35:563–565.CrossRefGoogle ScholarPubMed
11.King, TC, Price, PB. An evaluation of iodophors as skin antiseptics. Surg Gynecol Obstet 1963;116:361–365.Google ScholarPubMed
12.Champagne, S, Fussell, S, Scheifele, D. Evaluation of skin antisepsis prior to blood culture in neonates. Infect Control 1984;5:489–491.CrossRefGoogle ScholarPubMed
13.Lee, S, Schoen, I, Malkin, A. Comparison of use of alcohol with that of iodine for skin antisepsis in obtaining blood cultures. Am J Clin Pathol 1967;47:646–648.CrossRefGoogle ScholarPubMed
14.Shahar, E, Wohl-Gottesman, BS, Shenkman, L. Contamination of blood cultures during venepuncture: fact or myth? Postgrad Med J 1990;66:1053–1058.CrossRefGoogle ScholarPubMed