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Pseudomonas aeruginosa Infections Associated with Use of Povidone-Iodine in Patients Receiving Continuous Ambulatory Peritoneal Dialysis

Published online by Cambridge University Press:  21 June 2016

Angella Goetz
Affiliation:
Departments of Medicine, Veterans Administration Medical Center, Pittsburgh, Pennsylvania
Robert R. Muder*
Affiliation:
Departments of Medicine, Veterans Administration Medical Center, Pittsburgh, Pennsylvania Mercy Hospital of Pittsburgh, Pittsburgh, Pennsylvania
*
Infectious Disease Section, VA Medical Center, University Drive C, Pittsburgh, PA 15240

Abstract

Fifteen episodes of infection due to Pseudomonas aeruginosa, including peritonitis and catheter site infections, occurred in nine patients receiving continuous ambulatory peritoneal dialysis over a 27-month period. Eight episodes were associated with catheter loss. Occurrence of P aeruginosa infection was significantly associated with use of povidone-iodine solution to cleanse the catheter site. There was no association with use of povidone-iodine solution to disinfect tubing connections, use of other skin care products or exposure to other environmental sources of P aeruginosa. Cultures of available povidone-iodine products were negative. Local irritation and alteration in skin flora caused by antiseptic solution or low-level contamination of povidone-iodine solution are potential mechanisms of infection.

Type
Original Articles
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1989

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