Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-05T10:22:45.185Z Has data issue: false hasContentIssue false
  • English
  • Français

A Novel, Sporicidal Formulation of Ethanol for Glove Decontamination to Prevent Clostridium difficile Hand Contamination During Glove Removal

Published online by Cambridge University Press:  18 December 2015

Myreen E. Tomas ,
Michelle M. Nerandzic ,
Jennifer L. Cadnum ,
Thriveen S. C. Mana ,
Annette Jencson ,
Venkata Sunskesula ,
Sirisha Kundrapu ,
Brigid M. Wilson  and
Curtis J. Donskey
Myreen E. Tomas
Affiliation:
Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio
Michelle M. Nerandzic
Affiliation:
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio
Jennifer L. Cadnum
Affiliation:
Case Western Reserve University School of Medicine, Cleveland, Ohio
Thriveen S. C. Mana
Affiliation:
Case Western Reserve University School of Medicine, Cleveland, Ohio
Annette Jencson
Affiliation:
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio
Venkata Sunskesula
Affiliation:
Case Western Reserve University School of Medicine, Cleveland, Ohio
Sirisha Kundrapu
Affiliation:
Case Western Reserve University School of Medicine, Cleveland, Ohio
Brigid M. Wilson
Affiliation:
Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio
Curtis J. Donskey*
Affiliation:
Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio
*
Address correspondence to Curtis J. Donskey, MD, Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, Ohio 44106 ([email protected]).
Get access Rights & Permissions [Opens in a new window]

Abstract

Decontamination of gloves before removal could reduce the risk for contamination of hands of personnel caring for patients with Clostridium difficile infection. We demonstrated that a novel sporicidal formulation of ethanol rapidly reduced C. difficile spores on gloved hands without adverse odor, respiratory irritation, or staining of clothing.

Infect. Control Hosp. Epidemiol. 2016;37(3):337–339

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 37 , Issue 3 , March 2016 , pp. 337 - 339
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Kundrapu, S, Sunkesula, V, Jury, LA, Sitzlar, BM, Donskey, CJ. Daily disinfection of high-touch surfaces in isolation rooms to reduce contamination of healthcare workers’ hands. Infect Control Hosp Epidemiol 2012;33:1039–1042.CrossRefGoogle ScholarPubMed
2. Landelle, C, Verachten, M, Legrand, P, Girou, E, Barbut, F, Brun-Buisson, C. Contamination of healthcare workers’ hands with Clostridium difficile spores after caring for patients with C. difficile infection. Infect Control Hosp Epidemiol 2014;35:10–15.CrossRefGoogle ScholarPubMed
3. Arfons, L, Ray, AJ, Donskey, CJ. Clostridium difficile infection among healthcare workers receiving antibiotic therapy. Clin Infect Dis 2005;40:1384–1385.CrossRefGoogle ScholarPubMed
4. Hayden, MK, Blom, DW, Lyle, EA, Moore, CG, Weinstein, RA. Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant Enterococcus or the colonized patients’ environment. Infect Control Hosp Epidemiol 2008;29:149–154.CrossRefGoogle ScholarPubMed
5. Morgan, DJ, Liang, SY, Smith, CL, et al. Frequent multidrug-resistant Acinetobacter baumannii contamination of gloves, gowns, and hands of healthcare workers. Infect Control Hosp Epidemiol 2010;31:716–721.CrossRefGoogle ScholarPubMed
6. Kundrapu, S, Sunkesula, V, Jury, I, Deshpande, A, Donskey, CJ. A randomized trial of soap and water hand wash versus alcohol hand rub for removal of Clostridium difficile spores from hands of patients. Infect Control Hosp Epidemiol 2014;35:204–206.CrossRefGoogle ScholarPubMed
7. Tomas, ME, Kundrapu, S, Thota, P, et al. Contamination of the skin and clothing of healthcare personnel during removal of personal protective equipment [published online October 12, 2015]. JAMA Intern Med 2015.CrossRefGoogle ScholarPubMed
8. Tomas, ME, Sunkesula, VCK, Kundrapu, S, Wilson, BM, Donskey, CJ. An intervention to reduce healthcare personnel hand contamination during care of patients with Clostridium difficile infection. Am J Infect Control. In press.Google Scholar
9. Nerandzic, MM, Sunkesula, VCK, Sankar, T, Setlow, P, Donskey, CJ. Unlocking the sporicidal potential of ethanol: induced sporicidal activity of ethanol against Clostridium difficile and Bacillus spores under altered physical and chemical conditions. PLOS ONE 2015;10:e0132805.CrossRefGoogle ScholarPubMed
10. Nerandzic, MM, Sankar, T, Setlow, P, Donskey, CJ. A cumulative spore killing approach: synergistic sporicidal activity of dilute peracetic acid and ethanol at low pH against Clostridium difficile and Bacillus subtilis spores. Open Forum Infect Dis. In press.Google Scholar