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Nosocomial Neisseria meningitidis Molecular Analysis of a Clinical Problem

Published online by Cambridge University Press:  02 January 2015

Abstract

Over a 1-week period, Neisseria meningitidis serogroup B was recovered from two patients in the intensive-care unit (ICU). A cross-infection was presumed when one patient developed invasive meningococcal disease and another patient was found to be colonized. Investigation by molecular typing showed that these cases were not related, demonstrating the value of molecular typing when investigating potential cross-infections in a closed environment such as the ICU.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1997

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References

1. Broome, CV. The carrier state: Neisseria meningitidis . J Antimicrob Chemother 1986;18(suppl A):2534.Google Scholar
2. Cougant, DA, Hoiby, EA, Magnus, P, et al. Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population. J Clin Microbiol 1994;32:323330.Google Scholar
3. Greenfield, S, Sheehe, PR, Feldman, HA. Meningococcal carriage in a population of ‘normal’ families. J Infect Dis 1971;123:6773.CrossRefGoogle Scholar
4. Centers for Disease Control. Nosocomial meningococcemia—Wisconsin. MMWR 1978;27:358363.Google Scholar
5. Cohen, MS, Steere, AC, Baltimore, R, et al. Possible nosocomial transmission of group Y Neisseria meningitidis among oncology patients. Ann Intern Med 1979;91:712.Google Scholar
6. Rose, HD, Lenz, IE, Sheth, NK. Meningococcal pneumonia: a source of nosocomial infection. Arch Intern Med 1981;141:575577.CrossRefGoogle ScholarPubMed
7. Riewerts Eriksen, NH, Espersen, F, Laursen, L, et al. Nosocomial outbreak of group C meningococcal disease. Br Med J 1989;298:568569.CrossRefGoogle ScholarPubMed
8. Poh, CL, Lau, QC. Subtyping of Neisseria gonorrhoeae auxotypeserovar groups by pulsed-field gel electrophoresis. J Med Microbiol 1993;38:366370.CrossRefGoogle ScholarPubMed
9. Maslow, JN, Slutsky, AM, Arbeit, RD. Application of pulsed-field gel electrophoresis for molecular epidemiology. In: Persing, DH, Smith, TF, Tenover, FC, White, TJ, eds. Diagnostic Molecular Microbiology: Principles and Applications. Washington, DC: American Society for Microbiology; 1993:563572.Google Scholar
10. Maslow, JN, Slutsky, AM, Arbeit, RD. Characterization of pathogenic microorganisms by genomic fingerprinting using arbitrarily primed PCR. In: Persing, DH, Smith, TF, Tenover, FC, White, TJ, eds. Diagnostic Molecular Microbiology: Principles and Applications. Washington, DC: American Society for Microbiology; 1993:595602.Google Scholar
11. Advisory Committee on Epidemiology. Guidelines for control of meningococcal disease. Can Commun Dis Rep 1994;20:1727.Google Scholar
12. Maslow, JN, Mulligan, ME, Arbeit, RD. Molecular epidemiology: application of contemporary techniques to the typing of microorganisms. Clin Infect Dis 1993;17:153164.Google Scholar
13. Van Belkum, A, Van Leeuwen, W, Klutymans, J, et al. Molecular nosocomial epidemiology: high speed typing of microbial pathogens by arbitrary primed polymerase chain reaction assays. Infect Control Hosp Epidemiol 1995;16:658666.CrossRefGoogle ScholarPubMed